Phenotypes associated with this allele

• Allele Symbol: Cftr^tm3Bay
• Allele Name: targeted mutation 3, Baylor College of Medicine
• Allele ID: MGI:1857898
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cftr^tm3Bay/Cftr^tm3Bay	involves: 129S7/SvEvBrd	MGI:2177541

Genotype
MGI:2177541

hm1

• Allelic Composition: Cftr^tm3Bay/Cftr^tm3Bay
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:29656 )

• at least 60% die within one month after birth due to intestinal obstruction

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:29656 )

• exhibit dilatation of the crypts of Lieberkuhn and the presence of eosinophilic concretions in the crypts of the small and large intestine

abnormal digestive system physiology ( J:29656 )

• cAMP stimulated chloride secretion is defective in the colon

intestinal obstruction ( J:29656 )

• many exhibit intestinal disease as indicated by intestinal obstruction

growth/size/body

decreased body size ( J:29656 )

• those that survive the newborn period are smaller and grow more slowly

reproductive system

female infertility ( J:29656 )

♀ • adult females are almost always sterile, although males are fertile

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:29656 )

• exhibit dilatation of the crypts of Lieberkuhn and the presence of eosinophilic concretions in the crypts of the small and large intestine

abnormal pancreas morphology ( J:29656 )

• exhibit a variable degree of pancreatic atrophy

liver/biliary system

liver/biliary system phenotype ( J:29656 )

N • no abnormal liver/biliary system phenotypes detected

respiratory system

respiratory system phenotype ( J:29656 )

N • no abnormal respiratory system phenotypes detected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cystic fibrosis		DOID:1485	OMIM:219700	J:29656