Phenotypes associated with this allele

• Allele Symbol: Cdx2^tm1Fbe
• Allele Name: targeted mutation 1, F Beck
• Allele ID: MGI:1857928
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdx2^tm1Fbe/Cdx2^tm1Fbe	involves: 129S1/Sv * C57BL/6J	MGI:2175777
hm2	Cdx2^tm1Fbe/Cdx2^tm1Fbe	involves: ICR	MGI:3580005
ht3	Cdx2^tm1Fbe/Cdx2^+	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3613766
ht4	Cdx2^tm1Fbe/Cdx2^+	involves: 129S1/Sv * C57BL/6J	MGI:2175778
ht5	Cdx2^tm1Fbe/Cdx2^tm2.1Fbe	involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ	MGI:5308976
ht6	Cdx2^tm1.2Aral/Cdx2^tm1Fbe	involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL	MGI:5445753
cn7	Cdx2^tm1Fbe/Cdx2^tm2Fbe Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA	MGI:5308975
cn8	Cdx2^tm1.1Aral/Cdx2^tm1Fbe Tg(Zp3-cre)93Knw/0	involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL	MGI:5445751
cx9	Cdx2^tm1Fbe/Cdx2^+ Cdx4^tm1.1Jdes/Cdx4^+	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613771
cx10	Cdx2^tm1Fbe/Cdx2^+ Cdx4^tm1.1Jdes/Y	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613767

Genotype
MGI:2175777

hm1

• Allelic Composition: Cdx2^tm1Fbe/Cdx2^tm1Fbe
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:38772 )

• die between E3.5 and E5.5

reproductive system

failure of embryo implantation ( J:38772 )

♀

Genotype
MGI:3580005

hm2

• Allelic Composition: Cdx2^tm1Fbe/Cdx2^tm1Fbe
• Genetic Background: involves: ICR

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:98502 )

• homozygotes die around implantation

embryo

abnormal inner cell mass apoptosis ( J:98502 )

• a 3-fold increase in cell death is seen in the inner cell mass at E4.5

increased trophectoderm apoptosis ( J:98502 )

• an 8-fold increase in cell death is seen in the trophoectoderm at E4.5

failure of blastocyst to hatch from the zona pellucida ( J:98502 )

• at E4.5 embryos are still in the zona pellucida

abnormal blastocyst morphology ( J:98502 )

abnormal blastocoele morphology ( J:98502 )

• at E4.5, little or no blastocoelic cavity is seen

• the blastocoel is initially formed but collapses

abnormal trophectoderm morphology ( J:98502 )

• after 72 hours in culture (starting at the 8-cell stage) trophoectodermal cells appear rounded and non-epithelial

• tight and adherens junctions appear abnormal at the late blastocyst stage and it appears that the polarity and integrity of the trophoectoderm are not maintained

absent trophoblast giant cells ( J:98502 )

• trophoblast giant cells are not formed and trophoblast stem cell lines can not be established

abnormal trophoblast layer morphology ( J:98502 )

• trophoblast differentiation is impaired beyond the expanded blastocyst stage

cellular

abnormal inner cell mass apoptosis ( J:98502 )

• a 3-fold increase in cell death is seen in the inner cell mass at E4.5

increased trophectoderm apoptosis ( J:98502 )

• an 8-fold increase in cell death is seen in the trophoectoderm at E4.5

Genotype
MGI:3613766

ht3

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

embryo

abnormal placenta labyrinth morphology ( J:104372 )

• 6 of 62 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5

failure of chorioallantoic fusion ( J:104372 )

• allantois of 3 of 54 heterozygotes has not fused with the chorion at E9.5

Genotype
MGI:2175778

ht4

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

growth/size/body

decreased body weight ( J:38772 )

skeleton

abnormal rib morphology ( J:38772 )

vertebral transformation ( J:38772 )

• anterior homeotic shift of the cervical and thoracic spine such as an 8th rib attached to the sternum, or the second rib attached to the sternum at the top of the manubrium together with the first rib

thoracic vertebral transformation ( J:38772 )

• T3 shows morphological features characteristic of the immediately cranial vertebrae in the wild-type

cervical vertebral transformation ( J:38772 )

• C6 and C7 show morphological features characteristic of the immediately cranial vertebrae in the wild-type

limbs/digits/tail

short tail ( J:38772 )

• 50-60% exhibit a short or kinked tail

kinked tail ( J:38772 )

• 50-60% exhibit a short or kinked tail

neoplasm

increased intestinal adenoma incidence ( J:38772 )

• presence of multiple adenomatous polyps at 12-28 weeks of age

• tumors are found predominately in the proximal colon and occasionally in the small intestine

increased colon adenoma incidence ( J:38772 )

• tumors are found predominately in the proximal colon

• largest tumors are pedunculated tubulovillous colonic adenomata

digestive/alimentary system

increased intestinal adenoma incidence ( J:38772 )

• presence of multiple adenomatous polyps at 12-28 weeks of age

• tumors are found predominately in the proximal colon and occasionally in the small intestine

increased colon adenoma incidence ( J:38772 )

• tumors are found predominately in the proximal colon

• largest tumors are pedunculated tubulovillous colonic adenomata

Genotype
MGI:5308976

ht5

• Allelic Composition: Cdx2^tm1Fbe/Cdx2^tm2.1Fbe
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ

embryo

caudal body truncation ( J:179732 )

• at E10.5 in embryos grown on tetraploid trophoblast

Genotype
MGI:5445753

ht6

• Allelic Composition: Cdx2^tm1.2Aral/Cdx2^tm1Fbe
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:189005 )

• reach the blastocyst stage then collapse around implantation

embryo

embryonic growth arrest ( J:189005 )

• reach the blastocyst stage then collapse around implantation

Genotype
MGI:5308975

cn7

• Allelic Composition: Cdx2^tm1Fbe/Cdx2^tm2Fbe; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA

embryo

caudal body truncation ( J:179732 )

• at E10.5

Genotype
MGI:5445751

cn8

• Allelic Composition: Cdx2^tm1.1Aral/Cdx2^tm1Fbe; Tg(Zp3-cre)93Knw/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * SJL

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:189005 )

• reach the blastocyst stage then collapse around implantation

embryo

embryonic growth arrest ( J:189005 )

• reach the blastocyst stage then collapse around implantation

Genotype
MGI:3613771

cx9

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺; Cdx4^tm1.1Jdes/Cdx4⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

embryo

abnormal placenta labyrinth morphology ( J:104372 )

♀ • 2 of 11 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5

failure of chorioallantoic fusion ( J:104372 )

♀ • allantois of 2 of 28 mutants has not fused with the chorion at E9.5

Genotype
MGI:3613767

cx10

• Allelic Composition: Cdx2^tm1Fbe/Cdx2⁺; Cdx4^tm1.1Jdes/Y
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104372 )

♂ • die shortly after E10.5

growth/size/body

embryonic growth retardation ( J:104372 )

♂ • exhibit developmental retardation at E10.5

embryo

sirenomelia ( J:104372 )

♂ • truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

embryonic growth retardation ( J:104372 )

♂ • exhibit developmental retardation at E10.5

abnormal allantois morphology ( J:104372 )

♂ • allantoic endothelial cells often exhibit, to a variable extent, a poorer degree of primary vessel organization around the time of chorioallantoic fusion

abnormal placenta morphology ( J:104372 )

♂

abnormal placenta vasculature ( J:104372 )

♂ • at E10.5, maternal blood pools and embryonic blood vessels are widely separated

absent placenta hemotrichorial membrane ( J:104372 )

• the hemotrichorial membrane is almost completely absent

abnormal placenta labyrinth morphology ( J:104372 )

♂ • all embryos that do undergo chorioallantoic fusion display deficient placental labyrinth development at E10.5

♂ • fail to properly extend the allantoic vascular network into the chorionic ectoderm and do not develop a functional placental labyrinth

failure of chorioallantoic fusion ( J:104372 )

♂ • allantois of 7 of 35 mutants has not fused with the chorion at E9.5

skeleton

increased rib number ( J:104372 )

♂ • have 14 ribs due to the partial or complete bilateral rib attachment to V21

vertebral transformation ( J:104372 )

♂

thoracic vertebral transformation ( J:104372 )

♂ • 4 of 4 have the 8th pair of ribs attached to the sternum, indicating anterior transformation at the level of V15

lumbar vertebral transformation ( J:104372 )

♂ • 4 of 4 have a partial or complete rib attached to V21 bilaterally, at the position normally corresponding to the first lumbar vertebrae

homeostasis/metabolism

edema ( J:104372 )

♂ • thoracic edema at E10.5

limbs/digits/tail

sirenomelia ( J:104372 )

♂ • truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

cardiovascular system

abnormal placenta vasculature ( J:104372 )

♂ • at E10.5, maternal blood pools and embryonic blood vessels are widely separated