All Phenotypes Mmp7<tm1Lmm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp7^tm1Lmm/Mmp7^tm1Lmm	B6.129-Mmp7^tm1Lmm	MGI:4365576
hm2	Mmp7^tm1Lmm/Mmp7^tm1Lmm	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:4365582
hm3	Mmp7^tm1Lmm/Mmp7^tm1Lmm	involves: 129S1/Sv * 129X1/SvJ	MGI:4365575
hm4	Mmp7^tm1Lmm/Mmp7^tm1Lmm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2183288
cx5	Apc^tm1Mmt/Apc⁺ Mmp7^tm1Lmm/Mmp7^tm1Lmm Smad4^tm1Mmt/Smad4⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:4365607
cx6	Mmp7^tm1Lmm/Mmp7^tm1Lmm Tg(MMTV-PyVT)634Mul/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:4367709
cx7	Mmp7^tm1Lmm/Mmp7^tm1Lmm Timp1^tm1Pds/Timp1^tm1Pds	involves: 129S4/SvJae	MGI:3525491
cx8	Apc^Min/Apc⁺ Mmp7^tm1Lmm/Mmp7^tm1Lmm	involves: C57BL/6 * C57BL/6J	MGI:2183289

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:149388 )

• mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice

• mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice

decreased susceptibility to induced morbidity/mortality ( J:122893 )

• survival rate post-myocardial infarction is increased compared to in similarly treated wild-type mice

cardiovascular system

abnormal PR interval ( J:122893 )

• PR interval is not prolonged following myocardial infarction unlike in similarly treated wild-type mice

abnormal sinoatrial node conduction ( J:122893 )

• following myocardial infarction left ventricle epicardial conduction from apex to base is faster than in similarly treated wild-type mice

abnormal response to cardiac infarction ( J:122893 )

• survival rate post-myocardial infarction is increased compared to in similarly treated wild-type mice

• PR interval is not prolonged following myocardial infarction unlike in similarly treated wild-type mice

• following myocardial infarction left ventricle epicardial conduction from apex to base is faster than in similarly treated wild-type mice

digestive/alimentary system

digestive/alimentary phenotype ( J:149388 )

N	• cecal flora is normal

diarrhea ( J:149388 )

• mice fed 4% DSS water exhibit bloody diarrhea unlike similarly treated wild-type mice

intestinal ulcer ( J:149388 )

• in mice fed 1% DSS water

increased susceptibility to induced colitis ( J:149388 )

• mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice

• mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice

• mice fed 1% DSS water develop multiple erosions and intense inflammation in the cecum and colon with crypt destruction, mucosal ulcerations, erosions, and infiltration of leukocytes into mucosal tissue unlike similarly treated wild-type mice

immune system

increased susceptibility to induced colitis ( J:149388 )

• mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice

• mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice

increased interleukin-1 beta secretion ( J:149388 )

• cecum and colon organ cultures produce more IL1beta than cultures from wild-type mice

• cecum and colon organ cultures from mice fed DSS water exhibit increased IL1beta production compared with cultures from similarly treated wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:122893 )

• survival rate post-myocardial infarction is increased compared to in similarly treated wild-type mice

• PR interval is not prolonged following myocardial infarction unlike in similarly treated wild-type mice

• following myocardial infarction left ventricle epicardial conduction from apex to base is faster than in similarly treated wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:149388 )

• mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice

• mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice

impaired wound healing ( J:115243 )

• 24 hours following tracheal wound induction, mice exhibit no evidence of epithelial migration and fail to exhibit reduction in wound size unlike similarly treated wild-type mice

neoplasm

increased tumor incidence ( J:105098 )

• mice injected with Lewis lung carcinoma cells exhibit an increase in tumors compared with similarly treated wild-type mice

growth/size/body

weight loss ( J:149388 )

• mice fed 2% DSS water exhibit lose 30% body weight unlike similarly treated wild-type mice

Allelic Composition	Mmp7^tm1Lmm/Mmp7^tm1Lmm
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:124841 )

• macrophages fail to resorb co-cultured intervertebral discs unlike wild-type cells that reduce disc weight by 39%

• however, macrophage migration and chemotaxis are normal

impaired macrophage chemotaxis ( J:124841 )

• macrophage infiltration into co-cultured intervertebral discs is absent in the transitional zone and 96% reduced in the annulus fibrosus unlike wild-type macrophages

decreased tumor necrosis factor secretion ( J:124841 )

• macrophages co-cultured with intervertebral discs produce less than 2% of the soluble TNF-alpha produced by similarly treated wild-type cells

cellular

impaired macrophage chemotaxis ( J:124841 )

• macrophage infiltration into co-cultured intervertebral discs is absent in the transitional zone and 96% reduced in the annulus fibrosus unlike wild-type macrophages

hematopoietic system

abnormal macrophage physiology ( J:124841 )

• macrophages fail to resorb co-cultured intervertebral discs unlike wild-type cells that reduce disc weight by 39%

• however, macrophage migration and chemotaxis are normal

impaired macrophage chemotaxis ( J:124841 )

• macrophage infiltration into co-cultured intervertebral discs is absent in the transitional zone and 96% reduced in the annulus fibrosus unlike wild-type macrophages

Allelic Composition	Mmp7^tm1Lmm/Mmp7^tm1Lmm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:55723 )

N	• mice exhibit normal contact hypersensitivity in response to DNFB

decreased susceptibility to bacterial infection ( J:153651 )

• 4 hours after infection with Pseudomonas aeruginosa, mice exhibit less severe pneumonia than in similarly treated wild-type mice

• however, mice exhibit normal response 24 hours after P. aeruginosa infection

homeostasis/metabolism

decreased susceptibility to injury ( J:76811 )

• following pancreatic duct ligation, mice exhibit less acinar cell loss or ductal metaplasia compared with similarly treated wild-type mice

• following pancreatic duct ligation, mice fail to exhibit any increase in acinar cell apoptosis unlike in similarly treated wild-type mice

• however, mice subjected to pancreatic duct ligation exhibit local chronic pancreatitis immediately adjacent to the cut

Allelic Composition	Mmp7^tm1Lmm/Mmp7^tm1Lmm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal induced retina neovascularization ( J:119224 )

• following corneal wounding, mice exhibit a greater areas of neovascularization compared to in similarly treated wild-type mice

• however, corneal wound re-epithelialization is normal and implantation of bFGF (Fgf2) pellets restores normal neovascularization

vision/eye

abnormal induced retina neovascularization ( J:119224 )

• following corneal wounding, mice exhibit a greater areas of neovascularization compared to in similarly treated wild-type mice

• however, corneal wound re-epithelialization is normal and implantation of bFGF (Fgf2) pellets restores normal neovascularization

Allelic Composition	Apc^tm1Mmt/Apc⁺ Mmp7^tm1Lmm/Mmp7^tm1Lmm Smad4^tm1Mmt/Smad4⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Mmt mutation (0 available); any Apc mutation (158 available)
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)
Smad4^tm1Mmt mutation (0 available); any Smad4 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:142797 )

• mice exhibit a decrease in tumors size compared to in Apc^tm1Mmt Smad4^tm1Mmt homozygotes

• the ratio of small tumors is increased compared to in Apc^tm1Mmt Smad4^tm1Mmt homozygotes

• however, mice exhibit the same tumor invasion depth and number of fibroblasts in tumor stroma as in Apc^tm1Mmt Smad4^tm1Mmt homozygotes

decreased tumor incidence ( J:142797 )

• mice develop 50% fewer tumors than in Apc^tm1Mmt Smad4^tm1Mmt homozygotes

Allelic Composition	Mmp7^tm1Lmm/Mmp7^tm1Lmm Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:140033 )

• development of mammary gland tumors and metastasis to the lungs are similar to in Tg(MMTV-PyVT)634Mul mice

integument

increased mammary gland tumor incidence ( J:140033 )

• development of mammary gland tumors and metastasis to the lungs are similar to in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:140033 )

• development of mammary gland tumors and metastasis to the lungs are similar to in Tg(MMTV-PyVT)634Mul mice

Allelic Composition	Mmp7^tm1Lmm/Mmp7^tm1Lmm Timp1^tm1Pds/Timp1^tm1Pds
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)
Timp1^tm1Pds mutation (1 available); any Timp1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:94836 )

• bacterial clearance following corneal infection is increased compared to wild-type mice, however clearance is decreased compared to Timp1 single homozygotes

Allelic Composition	Apc^Min/Apc⁺ Mmp7^tm1Lmm/Mmp7^tm1Lmm
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Mmp7^tm1Lmm mutation (1 available); any Mmp7 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:38609 )

• average diameter of tumors is 20% smaller

increased tumor incidence ( J:38609 )

• although tumor incidence is increased relative to wild-type controls, incidence is reduced in comparison to animals heterozygous for Apc but Mmp7<+/+> by 58% (from 25.4 to 10.5 tumors/animal)

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