Phenotypes associated with this allele

• Allele Symbol: Prkdc^tm1Gcl
• Allele Name: targeted mutation 1, Gloria C Li
• Allele ID: MGI:1857934
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^tm1Gcl/Prkdc^tm1Gcl	involves: 129S1/Sv	MGI:4354496
hm2	Prkdc^tm1Gcl/Prkdc^tm1Gcl	involves: 129S1/Sv * C57BL/6	MGI:4354410

Genotype
MGI:4354496

hm1

• Allelic Composition: Prkdc^tm1Gcl/Prkdc^tm1Gcl
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:126920 )

• following exposure to ionizing radiation, thymic apoptosis is less and more evenly distributed than in similarly treated wild-type mice

cellular

cellular phenotype ( J:126920 )

N • radiation exposed mouse embryonic fibroblasts exhibit normal arrest at the G1/S transition

decreased thymocyte apoptosis ( J:126920 )

• following exposure to ionizing radiation, thymic apoptosis is less and more evenly distributed than in similarly treated wild-type mice

hematopoietic system

decreased thymocyte apoptosis ( J:126920 )

• following exposure to ionizing radiation, thymic apoptosis is less and more evenly distributed than in similarly treated wild-type mice

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:126920 )

• following exposure to ionizing radiation, thymic apoptosis is less and more evenly distributed than in similarly treated wild-type mice

Genotype
MGI:4354410

hm2

• Allelic Composition: Prkdc^tm1Gcl/Prkdc^tm1Gcl
• Genetic Background: involves: 129S1/Sv * C57BL/6

immune system

absent thymus corticomedullary boundary ( J:53765 )

• absent

small thymus ( J:53765 )

thymus hypoplasia ( J:53765 )

• thymi contain 50- to 100-fold fewer thymocytes compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:53765 )

• absent

arrested B cell differentiation ( J:53765 )

abnormal T cell receptor beta chain V(D)J recombination ( J:53765 )

• reduced in quantity and variety

abnormal T cell receptor delta chain V(D)J recombination ( J:53765 )

• increased

absent mature B cells ( J:53765 )

abnormal spleen morphology ( J:53765 )

• spleens lack lymphocytes

small spleen ( J:53765 )

• 5- to 10-fold

small Peyer's patches ( J:53765 )

• reduced or absent

absent Peyer's patches ( J:53765 )

• reduced or absent

abnormal lymph node morphology ( J:53765 )

• lymph nodes lack lymphocytes

small lymph nodes ( J:53765 )

• 5- to 10-fold

neoplasm

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

preneoplasia ( J:53765 )

• from 6 weeks to 6 months, mice exhibit preneoplastic lesions in the intestines unlike wild-type mice

cellular

increased cellular sensitivity to gamma-irradiation ( J:53765 )

• survive of fibroblasts exposed to gamma radiation is reduced 100-fold compared to similarly treated wild-type cells

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:53765 )

• 3 of 21 mice exhibit aberrant crypt foci unlike in wild-type mice

abnormal colon morphology ( J:53765 )

• colonic glands exhibit increased cellularity compared to in wild-type mice

intestine polyps ( J:53765 )

• between 1 and 6 months, mice exhibit inflammatory polyps unlike wild-type mice

• 15 of 21 mice exhibit hypeplastic polypoid lesions with mild to moderate to severe (in 8 of 21 cases) epithelial cell dysplasia and suggestion of lamina propria invasion in severe cases

hematopoietic system

absent thymus corticomedullary boundary ( J:53765 )

• absent

small thymus ( J:53765 )

thymus hypoplasia ( J:53765 )

• thymi contain 50- to 100-fold fewer thymocytes compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:53765 )

• absent

arrested B cell differentiation ( J:53765 )

abnormal T cell receptor beta chain V(D)J recombination ( J:53765 )

• reduced in quantity and variety

abnormal T cell receptor delta chain V(D)J recombination ( J:53765 )

• increased

absent mature B cells ( J:53765 )

abnormal spleen morphology ( J:53765 )

• spleens lack lymphocytes

small spleen ( J:53765 )

• 5- to 10-fold

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:53765 )

• 3 of 21 mice exhibit aberrant crypt foci unlike in wild-type mice

absent thymus corticomedullary boundary ( J:53765 )

• absent

small thymus ( J:53765 )

thymus hypoplasia ( J:53765 )

• thymi contain 50- to 100-fold fewer thymocytes compared to in wild-type mice

increased T cell derived lymphoma incidence ( J:53765 )

• in 3 mice between 3 and 12 months unlike wild-type mice