About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptentm1Ppp
targeted mutation 1, Pier Paolo Pandolfi
MGI:1857936
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptentm1Ppp/Ptentm1Ppp involves: 129S1/Sv * C57BL/6J MGI:2179024
ht2
 		Ptentm1Ppp/Pten+ involves: 129S1/Sv * C57BL/6J MGI:2179025
ht3
 		Ptentm1Ppp/Ptentm2Ppp involves: 129S1/Sv * C57BL/6 MGI:2679895
cn4
 		Ptentm1Ppp/Pten+
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S/Sv * C3H * C57BL/6 * CBA MGI:5050118
cx5
 		Akt1tm1Nhy/Akt1+
Akt2tm1Rsg/Akt2tm1Rsg
Ptentm1Ppp/Pten+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ MGI:3848161
cx6
 		Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp
Ptentm1Ppp/Ptentm1Ppp 		involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N MGI:5902970
cx7
 		Akt2tm1Rsg/Akt2tm1Rsg
Ptentm1Ppp/Pten+ 		involves: 129S1/Sv * C57BL/6 * DBA/1LacJ MGI:3848162
cx8
 		Ptentm1Ppp/Pten+
Tg(Pbsn-TAg)15Tvd/0 		involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:4836243


Genotype
MGI:2179024
hm1
Allelic
Composition		 Ptentm1Ppp/Ptentm1Ppp
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2179025
ht2
Allelic
Composition		 Ptentm1Ppp/Pten+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased malignant tumor incidence ( J:49532 )
• increased incidence of malignant tumors of various histological origins; age of incidence beginning at 6 months




Genotype
MGI:2679895
ht3
Allelic
Composition		 Ptentm1Ppp/Ptentm2Ppp
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
Ptentm2Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:86212 )
• incomplete penetrance
• 40% of males died in utero
• 75% of females died in utero

neoplasm
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

endocrine/exocrine glands
abnormal prostate gland morphology ( J:86212 )
• prostates were enlarged, irregular, and contained papillary projections 2 to 3 months after birth
• prostate growths detectable by 3 months of age
• growths surpassed the size of seminal vesicles by 6 to 8 months of age
prostate gland anterior lobe hyperplasia ( J:86212 )
• hypercellular with enlargements of the anterior lobes
prostate gland dorsolateral lobe hyperplasia ( J:86212 )
• hypercellular with enlargement of the dorsolateral lobes
prostate gland epithelial hyperplasia ( J:86212 )
• increased proliferation of epithelial cells
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

reproductive system
abnormal prostate gland morphology ( J:86212 )
• prostates were enlarged, irregular, and contained papillary projections 2 to 3 months after birth
• prostate growths detectable by 3 months of age
• growths surpassed the size of seminal vesicles by 6 to 8 months of age
prostate gland anterior lobe hyperplasia ( J:86212 )
• hypercellular with enlargements of the anterior lobes
prostate gland dorsolateral lobe hyperplasia ( J:86212 )
• hypercellular with enlargement of the dorsolateral lobes
prostate gland epithelial hyperplasia ( J:86212 )
• increased proliferation of epithelial cells
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma




Genotype
MGI:5050118
cn4
Allelic
Composition		 Ptentm1Ppp/Pten+
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S/Sv * C3H * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
Rac1tm1Tyb mutation (0 available); any Rac1 mutation (24 available)
Rac1tm2Tyb mutation (0 available); any Rac1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:173526 )
• embryo morphology is stated to be indistinguishable from that of mutant mice wild-type for Pten

cellular
abnormal apoptosis ( J:173526 )
• cell death is reduced compared to mutant mice wild-type for Pten




Genotype
MGI:3848161
cx5
Allelic
Composition		 Akt1tm1Nhy/Akt1+
Akt2tm1Rsg/Akt2tm1Rsg
Ptentm1Ppp/Pten+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Nhy mutation (0 available); any Akt1 mutation (34 available)
Akt2tm1Rsg mutation (0 available); any Akt2 mutation (53 available)
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating insulin level ( J:149156 )
• following glucose injection, mice exhibit a greater increase in serum insulin levels compared with similarly treated wild-type mice
impaired glucose tolerance ( J:149156 )
• mice exhibit impaired glucose tolerance that is not as severe as in Akt1tm1Nhy/Akt1tm1Nhy Akt2tm1Rsg/Akt2tm1Rsg mice
• however, mice exhibit normal glucose serum levels under normal conditions

endocrine/exocrine glands
enlarged pancreatic islets ( J:149156 )
• compared to in Akt2tm1Rsg homozygotes




Genotype
MGI:5902970
cx6
Allelic
Composition		 Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp
Ptentm1Ppp/Ptentm1Ppp
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
Ube2otm1.1(KOMP)Mbp mutation (1 available); any Ube2o mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:239679 )
• as in Ptentm1Ppp homozygotes




Genotype
MGI:3848162
cx7
Allelic
Composition		 Akt2tm1Rsg/Akt2tm1Rsg
Ptentm1Ppp/Pten+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1Rsg mutation (0 available); any Akt2 mutation (53 available)
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating insulin level ( J:149156 )
• compared to in Akt2tm1Rsg homozygotes
impaired glucose tolerance ( J:149156 )
• mice exhibit impaired glucose tolerance that is not as severe as in Akt2tm1Rsg homozygotes




Genotype
MGI:4836243
cx8
Allelic
Composition		 Ptentm1Ppp/Pten+
Tg(Pbsn-TAg)15Tvd/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Pbsn-TAg)15Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased prostate gland tumor incidence ( J:103408 )
• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice
increased prostate gland adenocarcinoma incidence ( J:103408 )
• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns
• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle
increased prostate intraepithelial neoplasia incidence ( J:103408 )
• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• mPIN lesions increase in severity with age
abnormal prostate gland physiology ( J:103408 )
• epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice
• apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

reproductive system
increased prostate gland tumor incidence ( J:103408 )
• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice
increased prostate gland adenocarcinoma incidence ( J:103408 )
• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns
• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle
increased prostate intraepithelial neoplasia incidence ( J:103408 )
• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• mPIN lesions increase in severity with age
abnormal prostate gland physiology ( J:103408 )
• epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice
• apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

neoplasm
increased prostate gland tumor incidence ( J:103408 )
• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice
increased prostate gland adenocarcinoma incidence ( J:103408 )
• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns
• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle
increased prostate intraepithelial neoplasia incidence ( J:103408 )
• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• mPIN lesions increase in severity with age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory