Analysis Tools
endocrine/exocrine glands
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• at 19-24 months of age, virgin female homozygotes exhibit extensive periductal lymphocyte infiltration into the interstitial space of mammary glands
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• at 10 weeks of age, mammary glands from postpubescent virgin female homoygotes show precocious alveolar differentiation and express casein(s) resembling early (day 14) pregnant wild-type glands
• however, female homozygotes are fertile and able to nurse and maintain a normal size litter, and display normal branching of the mammary ductal tree up to 5 weeks of age
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• at 19-24 months of age, virgin female homozygotes display mammary ductal dysplasia and stromal/fibroblastic hyperplasia with marked lymphocyte infiltration noted around the ducts
• in contrast to the mammary duct epithelium which becomes hyperplastic, the surrounding monolayer of myoepithelial cells remains normal
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• at 19-24 months of age, virgin female homozygotes display focal mammary alveolar hyperplasia
• secretory vacuoles are observed in alveoli of aging virgin homozygotes consistent with a differentiated hyperplastic phenotype
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• at 15 months of age, several multiparous females homozygotes display extensive mammary hyperplasia and dysplasia
• however, no palpable mammary tumors are observed up to 2 years of age
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integument
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• at 19-24 months of age, virgin female homozygotes exhibit extensive periductal lymphocyte infiltration into the interstitial space of mammary glands
|
|
|
• at 10 weeks of age, mammary glands from postpubescent virgin female homoygotes show precocious alveolar differentiation and express casein(s) resembling early (day 14) pregnant wild-type glands
• however, female homozygotes are fertile and able to nurse and maintain a normal size litter, and display normal branching of the mammary ductal tree up to 5 weeks of age
|
|
|
• at 19-24 months of age, virgin female homozygotes display mammary ductal dysplasia and stromal/fibroblastic hyperplasia with marked lymphocyte infiltration noted around the ducts
• in contrast to the mammary duct epithelium which becomes hyperplastic, the surrounding monolayer of myoepithelial cells remains normal
|
|
|
• at 19-24 months of age, virgin female homozygotes display focal mammary alveolar hyperplasia
• secretory vacuoles are observed in alveoli of aging virgin homozygotes consistent with a differentiated hyperplastic phenotype
|
|
|
• at 15 months of age, several multiparous females homozygotes display extensive mammary hyperplasia and dysplasia
• however, no palpable mammary tumors are observed up to 2 years of age
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