Phenotypes associated with this allele

• Allele Symbol: Mgmt^tm1Mse
• Allele Name: targeted mutation 1, Mutsuo Sekiguchi
• Allele ID: MGI:1857949
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgmt^tm1Mse/Mgmt^tm1Mse	involves: 129S/SvEv	MGI:3783426
cx2	Mgmt^tm1Mse/Mgmt^tm1Mse Mlh1^tm1Mse/Mlh1^tm1Mse	involves: 129S/SvEv	MGI:3783427

Genotype
MGI:3783426

hm1

• Allelic Composition: Mgmt^tm1Mse/Mgmt^tm1Mse
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:47642 )

• treatment of mice with 30 mg/kg methylnitrosourea induces death unlike in wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:47642 )

• mice are more susceptible to methylnitrosourea treatment than wild-type mice leading to decreased body weight, hemotopoietic cells, thymus and spleen size and death

neoplasm

increased T cell derived lymphoma incidence ( J:47642 )

• in more methylnitrosourea-treated mice than wild-type but fewer than in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

• lymphomas exhibit the same infiltration as in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:47642 )

• in more methylnitrosourea-treated mice than wild-type but fewer than in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

• lymphomas exhibit the same infiltration as in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

immune system

increased T cell derived lymphoma incidence ( J:47642 )

• in more methylnitrosourea-treated mice than wild-type but fewer than in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

• lymphomas exhibit the same infiltration as in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

hematopoietic system

increased T cell derived lymphoma incidence ( J:47642 )

• in more methylnitrosourea-treated mice than wild-type but fewer than in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

• lymphomas exhibit the same infiltration as in Mlh1^tm1Mse Mgmt^tm1Mse homozygotes

Genotype
MGI:3783427

cx2

• Allelic Composition: Mgmt^tm1Mse/Mgmt^tm1Mse; Mlh1^tm1Mse/Mlh1^tm1Mse
• Genetic Background: involves: 129S/SvEv

neoplasm

increased T cell derived lymphoma incidence ( J:47642 )

• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment

• in half of the affected mice, lymphomas infiltrate other organs

increased lung adenoma incidence ( J:47642 )

• in 2 methylnitrosourea-treated mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:47642 )

• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment

• in half of the affected mice, lymphomas infiltrate other organs

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:47642 )

N • unlike Mgmt^tm1Mse homozygotes, mice exhibit normal resistance to methylnitrosourea treatment

respiratory system

increased lung adenoma incidence ( J:47642 )

• in 2 methylnitrosourea-treated mice

immune system

increased T cell derived lymphoma incidence ( J:47642 )

• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment

• in half of the affected mice, lymphomas infiltrate other organs

hematopoietic system

increased T cell derived lymphoma incidence ( J:47642 )

• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment

• in half of the affected mice, lymphomas infiltrate other organs