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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmp8btm1Blh
targeted mutation 1, Brigid L Hogan
MGI:1857954
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bmp8btm1Blh/Bmp8btm1Blh B6.129-Bmp8btm1Blh MGI:2656839
hm2
 		Bmp8btm1Blh/Bmp8btm1Blh either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6) MGI:2451100
hm3
 		Bmp8btm1Blh/Bmp8btm1Blh involves: 129/Sv * Black Swiss MGI:2451094
ht4
 		Bmp8btm1Blh/Bmp8b+ either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6) MGI:2451099
cx5
 		Bmp4tm1Blh/Bmp4+
Bmp8btm1Blh/Bmp8b+ 		involves: 129/Sv * 129S2/SvPas * Black Swiss MGI:3834139
cx6
 		Bmp8atm1Blh/Bmp8a+
Bmp8btm1Blh/Bmp8b+ 		involves: 129/Sv * 129S6/SvEvTac * Black Swiss MGI:2450605


Genotype
MGI:2656839
hm1
Allelic
Composition		 Bmp8btm1Blh/Bmp8btm1Blh
Genetic
Background		 B6.129-Bmp8btm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:63160 )
• Background Sensitivity: by the 6th backcross generation onto C57BL/6, only 33% of expected homozygotes are viable after E9.25
• Background Sensitivity: occurring in N6 backcross generation onto C57BL/6, but not N5

embryo
delayed embryo turning ( J:63160 )
• 25% of embryos show delayed turning
embryonic growth retardation ( J:63160 )
• seen at E8.75-E9.25
absent allantois ( J:63160 )
• sometimes absent
small allantois ( J:63160 )
• shorter allantois length

growth/size/body
embryonic growth retardation ( J:63160 )
• seen at E8.75-E9.25

reproductive system

cellular




Genotype
MGI:2451100
hm2
Allelic
Composition		 Bmp8btm1Blh/Bmp8btm1Blh
Genetic
Background		 either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
delayed embryo turning ( J:63160 )
• 25% of mice exhibit delayed turning, N2-N6 backcross generation onto C57BL/6
absent allantois ( J:63160 )
• Background Sensitivity: 25% of mice lack an allantois, N2-N6 backcross generation onto C57BL/6
small allantois ( J:63160 )
• shorter allantois length at the headfold stage

reproductive system
absent primordial germ cells ( J:63160 )
• 92% of mutant embryos on a largely C57BL/6 background have no primordial germ cells

cellular
absent primordial germ cells ( J:63160 )
• 92% of mutant embryos on a largely C57BL/6 background have no primordial germ cells




Genotype
MGI:2451094
hm3
Allelic
Composition		 Bmp8btm1Blh/Bmp8btm1Blh
Genetic
Background		 involves: 129/Sv * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal male germ cell morphology ( J:34057 )
• 50% of mutant embryos show delayed male germ cell differentiation
decreased male germ cell number ( J:34057 )
• during early puberty
• complete germ cell depletion in all sterile males
• partial germ cell depletion in fertile males
abnormal primordial germ cell morphology ( J:63160 )
• primordial germ cell generation is delayed, with mutants showing no primordial germ cells at the late streak stage
decreased primordial germ cell number ( J:63160 )
• 57% of mutants have less than 40 primordial germ cells before the 24-somite stage
absent primordial germ cells ( J:63160 )
• 43% of mutants have no primordial germ cells
increased male germ cell apoptosis ( J:34057 )
• increase in apoptosis of germ cells in the degenerating seminiferous tubules
abnormal cell differentiation ( J:34057 )
• 50% of mutant embryos show delayed male germ cell differentiation
abnormal spermatogonia proliferation ( J:34057 )
• numbers of proliferating spermatogonia in the seminiferous tubules are decreased at 2 weeks of age

endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:34057 , J:46927 )
• the seminiferous epithelium contians only a single cell layer at 3 and 5 weeks of age (J:34057)
• in severe cases, only one layer of epithelium is present in the seminiferous tubule (J:46927)
seminiferous tubule degeneration ( J:34057 , J:46927 )
• tubules lack primary spermatocytes (J:34057)
• irregular elongated spermatids in the center (J:34057)
• spermatogonia and Sertoli cells at the periphery (J:34057)
• increased apoptosis of pachytene spermatocytes in early adulthood (J:34057)
(J:46927)
increased Leydig cell number ( J:34057 )
• local accumulation of interstitial Leydig cells in the seminiferous tubules in completely degenerated ares of the testis
small testis ( J:34057 , J:46927 )
• reduced testis size in fertile males (J:34057)
• testis size in sterile males is about 15% the size of testis in heterozygous littermates or wild-type mice (J:34057)
(J:46927)
testis degeneration ( J:34057 )
• complete testis degeneration in all sterile males
• partial degeneration in fertile males

reproductive system
abnormal male germ cell morphology ( J:34057 )
• 50% of mutant embryos show delayed male germ cell differentiation
decreased male germ cell number ( J:34057 )
• during early puberty
• complete germ cell depletion in all sterile males
• partial germ cell depletion in fertile males
abnormal primordial germ cell morphology ( J:63160 )
• primordial germ cell generation is delayed, with mutants showing no primordial germ cells at the late streak stage
decreased primordial germ cell number ( J:63160 )
• 57% of mutants have less than 40 primordial germ cells before the 24-somite stage
absent primordial germ cells ( J:63160 )
• 43% of mutants have no primordial germ cells
abnormal seminiferous tubule epithelium morphology ( J:34057 , J:46927 )
• the seminiferous epithelium contians only a single cell layer at 3 and 5 weeks of age (J:34057)
• in severe cases, only one layer of epithelium is present in the seminiferous tubule (J:46927)
seminiferous tubule degeneration ( J:34057 , J:46927 )
• tubules lack primary spermatocytes (J:34057)
• irregular elongated spermatids in the center (J:34057)
• spermatogonia and Sertoli cells at the periphery (J:34057)
• increased apoptosis of pachytene spermatocytes in early adulthood (J:34057)
(J:46927)
increased Leydig cell number ( J:34057 )
• local accumulation of interstitial Leydig cells in the seminiferous tubules in completely degenerated ares of the testis
small testis ( J:34057 , J:46927 )
• reduced testis size in fertile males (J:34057)
• testis size in sterile males is about 15% the size of testis in heterozygous littermates or wild-type mice (J:34057)
(J:46927)
testis degeneration ( J:34057 )
• complete testis degeneration in all sterile males
• partial degeneration in fertile males
abnormal spermatogenesis ( J:34057 )
• germ cell proliferation at puberty is blocked in 20-30% of testes
• delayed and reduced germ cell proliferation and differentiation in the remainder of testes
abnormal spermatogonia proliferation ( J:34057 )
• numbers of proliferating spermatogonia in the seminiferous tubules are decreased at 2 weeks of age
abnormal reproductive system physiology ( J:63160 )
• primordial germ cell generation is delayed, with mutants showing no primordial germ cells at the late streak stage
increased male germ cell apoptosis ( J:34057 )
• increase in apoptosis of germ cells in the degenerating seminiferous tubules
male infertility ( J:34057 )
• 10 of 18 homozygous males are sterile

embryo
embryonic growth retardation ( J:63160 )
• most embryos are developmentally retarded at E7.5-8.25
abnormal allantois morphology ( J:63160 )
• allantois is more elongated at the headfold stage, but is shorter overall than in wild-type
delayed allantois development ( J:63160 )
• no allantoic bud is seen at the late streak stage and only a small bud is present at the neural plate stage indicating delayed allantois initiation

growth/size/body
embryonic growth retardation ( J:63160 )
• most embryos are developmentally retarded at E7.5-8.25




Genotype
MGI:2451099
ht4
Allelic
Composition		 Bmp8btm1Blh/Bmp8b+
Genetic
Background		 either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:63160 )
• reduced number of PGCs in mice on a largely C57BL/6 background
• at the headfold stage, the mean number of PBCs is about 60% that of wild-type

cellular
decreased primordial germ cell number ( J:63160 )
• reduced number of PGCs in mice on a largely C57BL/6 background
• at the headfold stage, the mean number of PBCs is about 60% that of wild-type




Genotype
MGI:3834139
cx5
Allelic
Composition		 Bmp4tm1Blh/Bmp4+
Bmp8btm1Blh/Bmp8b+
Genetic
Background		 involves: 129/Sv * 129S2/SvPas * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (23 available)
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:63160 )
• number of primordial germ cells is lower than in wild-type, but similar to numbers seen in Bmpb8 heterozygotes

cellular
decreased primordial germ cell number ( J:63160 )
• number of primordial germ cells is lower than in wild-type, but similar to numbers seen in Bmpb8 heterozygotes




Genotype
MGI:2450605
cx6
Allelic
Composition		 Bmp8atm1Blh/Bmp8a+
Bmp8btm1Blh/Bmp8b+
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8atm1Blh mutation (0 available); any Bmp8a mutation (19 available)
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell morphology ( J:46927 )
• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8atm1Blh mice
abnormal spermatogenesis ( J:46927 )
• about 50% of male mice examined exhibited abnormalities similar to Bmp8atm1Blh/ Bmp8atm1Blh mice
epididymis epithelium degeneration ( J:46927 )
• is sometimes observed

immune system
granulomatous inflammation ( J:46927 )
• is sometimes noted in the epididymal tubules of breeding male mice

cellular
abnormal male germ cell morphology ( J:46927 )
• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8atm1Blh mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory