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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apex1tm1Cur
targeted mutation 1, Tom Curran
MGI:1857956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apex1tm1Cur/Apex1tm1Cur involves: 129S1/Sv * C57BL/6J MGI:4358401
ht2
Apex1tm1Cur/Apex1+ involves: 129S1/Sv MGI:4358411


Genotype
MGI:4358401
hm1
Allelic
Composition
Apex1tm1Cur/Apex1tm1Cur
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apex1tm1Cur mutation (0 available); any Apex1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• mice are unable to develop beyond implantation
• however, cultured blastocysts exhibit normal growth and hatching




Genotype
MGI:4358411
ht2
Allelic
Composition
Apex1tm1Cur/Apex1+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apex1tm1Cur mutation (0 available); any Apex1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• under anesthetized conditions
• vascular smooth muscle cells exhibit increased apoptosis in response to Fas ligand compared with wild-type cells
• in response to phenylephrine with L-NAME
• in response to phenylephrine
• in response to acetycholine
• mice exhibit reduced neointimal hyperplasia in response to femoral artery wire injury compared to similarly treated wild-type mice
• mice fail to exhibit an increase in IL10 and IL1a levels following injury compared with similarly treated wild-type mice

homeostasis/metabolism
• mice exhibit reduced neointimal hyperplasia in response to femoral artery wire injury compared to similarly treated wild-type mice
• mice fail to exhibit an increase in IL10 and IL1a levels following injury compared with similarly treated wild-type mice
• basal serum nitric oxide metabolites compared with wild-type mice
• mice exhibits reduced vasodilation in response to acetylcholine and altered vascular tone in response to phenylephrine with or without L-NAME compared with wild-type mice

immune system

muscle
• vascular smooth muscle cells exhibit increased apoptosis in response to Fas ligand compared with wild-type cells
• in response to phenylephrine with L-NAME
• in response to phenylephrine
• in response to acetycholine





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory