All Phenotypes Hoxd3<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxd3^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:1857959

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2170429
cx2	Hoxb3^tm1Mrc/Hoxb3^tm1Mrc Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3611935
cx3	Hoxa3^tm1Mrc/Hoxa3^tm1Mrc Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd	MGI:4461316
cx4	Hoxa3^tm2Nrm/Hoxa3⁺ Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd	MGI:4461314
cx5	Hoxa3^tm2Nrm/Hoxa3^tm2Nrm Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd	MGI:4461315
cx6	Hoxa3^tm1Mrc/Hoxa3⁺ Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3611937
cx7	Hoxa3^tm1Mrc/Hoxa3^tm1Mrc Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3612029

Allelic Composition	Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd3^tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:15678 )

• survival normal through to birth

• many die within the first 5 days of life

• surviving mice are fertile

skeleton

asymmetric sternocostal joints ( J:15678 )

• the rib fusions on the two sides of the stermum are offset from one another

abnormal cervical vertebrae morphology ( J:15678 )

abnormal cervical atlas morphology ( J:15678 )

• the atlas is narrower than normal

• intermediate transformation of atlas in 15% of mice, remains independent vertebrum but osseous bridges develop to skull

• atlantal neural arch is usually incomplete

fusion of atlas and occipital bones ( J:15678 )

• the anterior arch of the atlas is assimilated into caudal part of the basioccipital bone

abnormal cervical axis morphology ( J:15678 )

• axis lacks superior articular surfaces

• thicker neural arch on axis

• cartilaginous foramina of normal atlas now in axis (sometimes only unilateral)

absent odontoid process ( J:15678 )

• axis lacks dens

cardiovascular system

abnormal vertebral artery morphology ( J:15678 )

• vertebral artery enters spinal canal more caudally than normal

nervous system

abnormal spinal nerve morphology ( J:15678 )

• first cervical nerve runs through a foramen in the floor of the skull

craniofacial

fusion of atlas and occipital bones ( J:15678 )

• the anterior arch of the atlas is assimilated into caudal part of the basioccipital bone

Allelic Composition	Hoxb3^tm1Mrc/Hoxb3^tm1Mrc Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3^tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
Hoxd3^tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:45337 )

• all homozygotes dead by the end of the first week after birth

neonatal lethality, incomplete penetrance ( J:45337 )

• about 50% die at birth

skeleton

abnormal hyoid bone morphology ( J:45337 )

• greater horn sometimes fused to thyroid cartilage

hyoid bone hypoplasia ( J:19447 )

• reduced in size

abnormal thyroid cartilage morphology ( J:19447 )

• dorsally associated cartilage of thyroid cartilage is missing

abnormal inferior horn of thyroid cartilage morphology ( J:19447 )

• the inferior horns are absent

abnormal cervical vertebrae morphology ( J:19447 , J:45337 )

abnormal cervical atlas morphology ( J:19447 )

• neural arch resembles more posterior cervical vertebrae (C3-C5)

absent cervical atlas ( J:19447 )

• atlas missing, with small cartilage remnants

nervous system

fusion of glossopharyngeal and vagus nerve ( J:45337 )

• partial deletion of cranial nerve IX or fusion to cranial nerve X, increased penetrance

endocrine/exocrine glands

abnormal ultimobranchial body morphology ( J:46523 )

• low penetrance of partially fused ultimobranchial bodies

respiratory system

abnormal thyroid cartilage morphology ( J:19447 )

• dorsally associated cartilage of thyroid cartilage is missing

abnormal inferior horn of thyroid cartilage morphology ( J:19447 )

• the inferior horns are absent

craniofacial

abnormal hyoid bone morphology ( J:45337 )

• greater horn sometimes fused to thyroid cartilage

hyoid bone hypoplasia ( J:19447 )

• reduced in size

embryo

abnormal ultimobranchial body morphology ( J:46523 )

• low penetrance of partially fused ultimobranchial bodies

Allelic Composition	Hoxa3^tm1Mrc/Hoxa3^tm1Mrc Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxd3^tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal basioccipital bone morphology ( J:161296 )

absent cervical atlas ( J:161296 )

• absent

craniofacial

abnormal basioccipital bone morphology ( J:161296 )

Allelic Composition	Hoxa3^tm2Nrm/Hoxa3⁺ Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)
Hoxd3^tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:161296 )

• authors state than mice resemble Hoxd3^tm1Mrc homozygotes

Allelic Composition	Hoxa3^tm2Nrm/Hoxa3^tm2Nrm Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal basioccipital bone morphology ( J:161296 )

absent cervical atlas ( J:161296 )

• absent

craniofacial

abnormal basioccipital bone morphology ( J:161296 )

Allelic Composition	Hoxa3^tm1Mrc/Hoxa3⁺ Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

ectopic thymus ( J:46523 )

• lobes of thymus displaced anteriorly

endocrine/exocrine glands

ectopic parathyroid gland ( J:46523 )

• ectopic parathyroids near the anterior ends of the thymus

ectopic thymus ( J:46523 )

• lobes of thymus displaced anteriorly

hematopoietic system

ectopic thymus ( J:46523 )

• lobes of thymus displaced anteriorly

Allelic Composition	Hoxa3^tm1Mrc/Hoxa3^tm1Mrc Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

athymia ( J:19447 )

abnormal thyroid gland morphology ( J:46523 )

• pyramidal ventral lobes

persistent ultimobranchial bodies ( J:46523 )

• ultimobranchial bodies, 100% persistent in adults

immune system

athymia ( J:19447 )

embryo

persistent ultimobranchial bodies ( J:46523 )

• ultimobranchial bodies, 100% persistent in adults

hematopoietic system

athymia ( J:19447 )

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