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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxd12tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:1857964
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxd12tm1Mrc/Hoxd12tm1Mrc involves: 129S7/SvEvBrd MGI:3513035
ht2
 		Hoxd12tm1Mrc/Hoxd12+ involves: 129S7/SvEvBrd MGI:3513033


Genotype
MGI:3513035
hm1
Allelic
Composition		 Hoxd12tm1Mrc/Hoxd12tm1Mrc
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12tm1Mrc mutation (0 available); any Hoxd12 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal carpal bone morphology ( J:32603 )
• the wrist carpal bone d4 shows a subtle, characteristic indentation at its distal border; possibly due to inappropriate fusion of the prechondrogenic condensations
brachyphalangia ( J:32603 )
• phalange 1 of digit II is reduced in length (80% of normal bone length) while phalange 2 of digit V is 55% of normal bone length
abnormal forelimb morphology ( J:32603 )
• homozygotes are overtly normal but display mild malformations in the forelimb, including reductions in the length of several autopodal bones
short metacarpal bones ( J:32603 )
• mutant metacarpals of digits II and V appear shortened relative to wild-type

skeleton
abnormal carpal bone morphology ( J:32603 )
• the wrist carpal bone d4 shows a subtle, characteristic indentation at its distal border; possibly due to inappropriate fusion of the prechondrogenic condensations
brachyphalangia ( J:32603 )
• phalange 1 of digit II is reduced in length (80% of normal bone length) while phalange 2 of digit V is 55% of normal bone length
short metacarpal bones ( J:32603 )
• mutant metacarpals of digits II and V appear shortened relative to wild-type




Genotype
MGI:3513033
ht2
Allelic
Composition		 Hoxd12tm1Mrc/Hoxd12+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12tm1Mrc mutation (0 available); any Hoxd12 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:32603 )
• the autopods of heterozygotes appear normal except for the appearance at low penetrance (~6%) of a tiny bony element located postaxially to digit V




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory