All Phenotypes Apc<tm1Tno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apc^tm1Tno
targeted mutation 1, Tetsuo Noda
MGI:1857966

Summary

29 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apc^tm1Tno/Apc^tm1Tno	involves: 129 * 129S4/SvJae * C57BL/6	MGI:4429571
hm2	Apc^tm1Tno/Apc^tm1Tno	involves: 129S4/SvJae * C57BL/6	MGI:2182592
ht3	Apc^tm1Tno/Apc⁺	involves: 129 * 129S4/SvJae * C57BL/6	MGI:4429573
ht4	Apc^tm1.1Tno/Apc^tm1Tno	involves: 129 * 129S4/SvJae * BALB/cJ * C57BL/6	MGI:4429569
ht5	Apc^Min/Apc^tm1Tno	involves: 129 * 129S4/SvJae * C57BL/6	MGI:4429565
cn6	Apc^tm1Tno/Apc⁺ Il17ra^tm1Koll/Il17ra^tm1Koll Tg(CDX2-cre)101Erf/0	involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J	MGI:5446625
cn7	Apc^tm1Tno/Apc⁺ Il23a^tm1Ngh/Il23a^tm1Ngh Tg(CDX2-cre)101Erf/0	involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J	MGI:5446624
cn8	Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw	involves: 129 * C57BL/6 * CBA	MGI:4943266
cn9	Tigar^{Gt(EUCE0047g05)Hmgu}/Tigar^{Gt(EUCE0047g05)Hmgu} Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5522716
cn10	Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5898006
cn11	Apc^tm1Tno/Apc^tm1Tno Elp3^tm1.1Tac/Elp3^tm1.1Tac Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac	MGI:5898005
cn12	Apc^tm1Tno/Apc⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA	MGI:3829449
cn13	Apc^tm1Tno/Apc⁺ Rac3^tm1.1Bea/Rac3^tm1.1Bea Tg(Vil1-cre/ERT2)23Syr/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2	MGI:6715667
cn14	Apc^tm1Tno/Apc⁺ Tg(CDX2-cre/ERT)#Erf/0	involves: 129S4/SvJae	MGI:5446623
cn15	Apc^tm1Tno/Apc^tm1Tno Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2	MGI:5566610
cn16	Apc^tm1Tno/Apc⁺ Il23r^tm1.2Trin/Il23r^tm1.2Trin Tg(CDX2-cre)101Erf/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J	MGI:5446693
cn17	Apc^tm1Tno/Apc^tm1Tno Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:4943265
cn18	Apc^tm1Tno/Apc^tm1Tno Pten^tm1Hwu/Pten^tm1Hwu Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:4943267
cn19	Apc^tm1Tno/Apc⁺ Tg(Vil1-cre)997Gum/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844314
cn20	Apc^tm1Tno/Apc^tm1Tno Tg(CDX2-cre)101Erf/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844313
cn21	Apc^tm1Tno/Apc^tm1Tno Tg(Vil1-cre)997Gum/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844315
cn22	Apc^tm1Tno/Apc⁺ Tg(CDX2-cre)101Erf/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844311
cn23	Apc^tm1Tno/Apc⁺ Tg(CDX2-cre*)189Erf/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844298
cn24	Apc^tm1Tno/Apc^tm1Tno Tg(CDX2-cre*)189Erf/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844297
cn25	Apc^tm1Tno/Apc^tm1Tno Tg(Cdh16-cre)91Igr/0	involves: 129S4/SvJae * ICR	MGI:5285852
cn26	Apc^tm1Tno/Apc⁺ Brf1^tm1Arte/Brf1^tm1Arte Tg(Cyp1a1-cre)1Dwi/0	involves: C57BL/6 * CBA	MGI:6403689
cx27	Apc^tm1Tno/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4429576
cx28	Apc^Min/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4429574
cx29	Apc^tm1Tno/Apc^tm1Tno Pten^tm2Mak/Pten^tm2Mak	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5779541

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Liver zonation is affected in hypomorphic Apc^tm1Tno/Apc^tm1Tno mutant mice

neoplasm

increased incidence of tumors by chemical induction ( J:156864 )

• exposure to the liver-specific carcinogen diethylnitrosamine results in a higher tumor incidence than in heterozygous mice

increased hepatocellular carcinoma incidence ( J:156864 )

• all mutant mice (n=15) develop hepatocellular carcinomas by 450 days of age

• hepatic tumor volumes in homozygous mice are larger than in heterozygous mice

• no intestinal polyps (>18 month, n=24)

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:156864 )

• exposure to the liver-specific carcinogen diethylnitrosamine results in a higher tumor incidence than in heterozygous mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:156864 )

• all mutant mice (n=15) develop hepatocellular carcinomas by 450 days of age

• hepatic tumor volumes in homozygous mice are larger than in heterozygous mice

• no intestinal polyps (>18 month, n=24)

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased colon adenoma incidence ( J:43301 )

• colorectal adenomas observed when exon 14 was deleted by colorectal infection of an adenovirus exressing Cre recombinase

digestive/alimentary system

increased colon adenoma incidence ( J:43301 )

• colorectal adenomas observed when exon 14 was deleted by colorectal infection of an adenovirus exressing Cre recombinase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:43301

Allelic Composition	Apc^tm1Tno/Apc⁺
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:156864 )

• low incidence (<10%)

• hepatic tumor volumes are smaller than in homozygous mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:156864 )

• low incidence (<10%)

• hepatic tumor volumes are smaller than in homozygous mice

Allelic Composition	Apc^tm1.1Tno/Apc^tm1Tno
Genetic Background	involves: 129 * 129S4/SvJae * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1.1Tno mutation (0 available); any Apc mutation (158 available)
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156864 )

• no mutant mice found at birth

nervous system

abnormal brain development ( J:156864 )

• embryos lack all structures anterior to the hindbrain at embryonic day 9.5 (E9.5), E12 and E16

absent midbrain ( J:156864 )

absent forebrain ( J:156864 )

craniofacial

absent mandible ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent mandible at E12

acrania ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent cranial structures at E12

skeleton

absent mandible ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent mandible at E12

acrania ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent cranial structures at E12

Allelic Composition	Apc^Min/Apc^tm1Tno
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Anterior head defects during embryonic development in Apc^Min/Apc^tm1Tno embryos and rescue of head defects by Ctnnb1^tm4.1Wbm/Ctnnb1⁺

mortality/aging

perinatal lethality, complete penetrance ( J:156864 )

• no mutant mice found at term

lethality throughout fetal growth and development, incomplete penetrance ( J:156864 )

• live embryos could still be detected at embryonic day 17.5 (E17.5), but at less than the expected Mendelian ratio

nervous system

abnormal brain development ( J:156864 )

• lack all structures anterior to the hindbrain at E12

• first become visible in E8.5-E9.5

absent midbrain ( J:156864 )

absent forebrain ( J:156864 )

craniofacial

absent mandible ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent mandible at E12

acrania ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent cranial structures at E12

skeleton

absent mandible ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent mandible at E12

acrania ( J:156864 )

• a prominent cap of neural tissue at the most anterior part of the embryo at E12

• absent cranial structures at E12

Allelic Composition	Apc^tm1Tno/Apc⁺ Il17ra^tm1Koll/Il17ra^tm1Koll Tg(CDX2-cre)101Erf/0
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Il17ra^tm1Koll mutation (0 available); any Il17ra mutation (47 available)
Tg(CDX2-cre)101Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:189226 )

• reduced colorectal tumor multiplicity and grown compared to in Apc^tm1Tno/Apc⁺ Tg(CDX2-cre)101Erf mice

Allelic Composition	Apc^tm1Tno/Apc⁺ Il23a^tm1Ngh/Il23a^tm1Ngh Tg(CDX2-cre)101Erf/0
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Il23a^tm1Ngh mutation (0 available); any Il23a mutation (27 available)
Tg(CDX2-cre)101Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:189226 )

• reduced colorectal tumor multiplicity and grown due to reduced cell proliferation compared with Apc^tm1Tno/Apc⁺ Tg(CDX2-cre)101Erf mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Gsk3a^tm1Jrw mutation (0 available); any Gsk3a mutation (18 available)
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:164579 )

• mice develop hyperplastic lesions in the bladder unlike wild-type mice

Allelic Composition	Tigar^{Gt(EUCE0047g05)Hmgu}/Tigar^{Gt(EUCE0047g05)Hmgu} Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)
Tigar^{Gt(EUCE0047g05)Hmgu} mutation (0 available); any Tigar mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:198650 )

• in tamoxifen-treated mice compared with Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ mice

neoplasm

decreased tumor growth/size ( J:198650 )

• tamoxifen-treated mice exhibit a reduced total tumor burden and average tumor size of abnormally proliferating adenomas in the small intestine and reduced size, but not number, of colon adenomas due to reduced proliferation and increased reactive oxygen species damage compared with Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased intestinal adenoma incidence ( J:227334 )

• tamoxifen treated mice develop numerous hyperplasias in the intestine

neoplasm

increased intestinal adenoma incidence ( J:227334 )

• tamoxifen treated mice develop numerous hyperplasias in the intestine

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Elp3^tm1.1Tac/Elp3^tm1.1Tac Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Elp3^tm1.1Tac mutation (0 available); any Elp3 mutation (40 available)
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:227334 )

• the amount of Dclk1+/Sox9+ cells in the Lgr5+ population is decreased in ex vivo organoids

abnormal small intestinal crypt cell physiology ( J:227334 )

• intestinal crypts fail to efficiently generate spheroid structures ex vivo

neoplasm

decreased tumor growth/size ( J:227334 )

• tamoxifen treated mice exhibit decreased numbers of hyperplastic foci/polyps in the intestine indicating impaired tumor initiation

Allelic Composition	Apc^tm1Tno/Apc⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Pten^tm2Mak mutation (4 available); any Pten mutation (89 available)
Tg(Cyp1a1-cre/ERT)1Dwi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:143082 )

• tamoxifen- and beta-naphthoflavone-induced mice median survival is 99 days compared to 405 days for wild-type Pten homozygotes or 409 days for wild-type Apc homozygotes

digestive/alimentary system

abnormal small intestine morphology ( J:143082 )

• 95% of tamoxifen- and beta-naphthoflavone-induced mice exhibit large, flattened, ulcerated lesions in the small intestine unlike control mice homozygous for either a wild-type Pten or Apc allele

increased intestinal adenocarcinoma incidence ( J:143082 )

• tamoxifen- and beta-naphthoflavone-induced mice develop invasive adenocarcinomas in the small intestines with luminal ulceration, and both acute and chronic inflammation compared to control mice that exhibit begnin neoplasms

• invasion and destruction of the small intestinal wall and peritoneal serosa results in localized peritonitis in tamoxifen- and beta-naphthoflavone-induced mice

peritoneal inflammation ( J:143082 )

• invasion and destruction of the small intestinal wall and peritoneal serosa by adenocarcinomas results in localized peritonitis in tamoxifen- and beta-naphthoflavone-induced mice

neoplasm

increased intestinal adenocarcinoma incidence ( J:143082 )

• invasion and destruction of the small intestinal wall and peritoneal serosa results in localized peritonitis in tamoxifen- and beta-naphthoflavone-induced mice

immune system

peritoneal inflammation ( J:143082 )

• invasion and destruction of the small intestinal wall and peritoneal serosa by adenocarcinomas results in localized peritonitis in tamoxifen- and beta-naphthoflavone-induced mice

Allelic Composition	Apc^tm1Tno/Apc⁺ Rac3^tm1.1Bea/Rac3^tm1.1Bea Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Rac3^tm1.1Bea mutation (0 available); any Rac3 mutation (13 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased alimentary system tumor incidence ( J:306088 )

• reduced number of intestinal tumors in duodenum and jejunum

• normal number of intestinal tumors in ileum and colon

decreased intestinal adenoma incidence ( J:306088 )

• reduced number of intestinal tumors in duodenum and jejunum

neoplasm

decreased tumor growth/size ( J:306088 )

• tumors less proliferative

• reduced ability to form colonies from single tumor cells in vitro

abnormal tumor susceptibility ( J:306088 )

• median intestinal tumor-free survival 138 vs 171 days

decreased alimentary system tumor incidence ( J:306088 )

• reduced number of intestinal tumors in duodenum and jejunum

• normal number of intestinal tumors in ileum and colon

decreased intestinal adenoma incidence ( J:306088 )

• reduced number of intestinal tumors in duodenum and jejunum

Allelic Composition	Apc^tm1Tno/Apc⁺ Tg(CDX2-cre/ERT)#Erf/0
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(CDX2-cre/ERT)#Erf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased gastrointestinal tumor incidence ( J:189226 )

• transformed colonic tissue in tamoxifen-treated mice

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:189226 )

• transformed colonic tissue in tamoxifen-treated mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120308 )

• most mice die by 15 months of age

neoplasm

increased tumor incidence ( J:120308 )

• a few mice develop unidentified tumors in the scrotal region, not obviously associated with the testes; these tumors are cystic and epithelial in origin

increased prostate gland adenocarcinoma incidence ( J:120308 )

• all prostate lobes exhibit neoplasia with hyperplasia, multiple foci of squamous metaplasia and keratinization, and a prominent stromal reaction, including edema, inflammatory reaction and stromal hyperplasia by 7 months of age indicating adenocarcinoma

• the anterior prostate shows the most severe phenotype, followed by the dorsal-lateral and then ventral prostate

• small foci of tumor invasion into the stroma is seen but this is not common

• mice castrated at 6 weeks show regions of hyperplasia, and squamous metaplasia at 32 weeks later, but not carcinoma, indicating inhibition of tumor formation

• mice castrated after tumors still exhibit carcinoma 2 months postcastration

increased prostate intraepithelial neoplasia incidence ( J:120308 )

• mice develop prostatic epithelial hyperplasia and prostatic intraepithelial neoplasia (PIN) as early as 4.5 to 7 weeks of age

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:120308 )

• mice develop prostatic epithelial hyperplasia as early as 4.5 to 7 weeks of age

increased prostate gland adenocarcinoma incidence ( J:120308 )

• the anterior prostate shows the most severe phenotype, followed by the dorsal-lateral and then ventral prostate

• small foci of tumor invasion into the stroma is seen but this is not common

• mice castrated at 6 weeks show regions of hyperplasia, and squamous metaplasia at 32 weeks later, but not carcinoma, indicating inhibition of tumor formation

• mice castrated after tumors still exhibit carcinoma 2 months postcastration

increased prostate intraepithelial neoplasia incidence ( J:120308 )

• mice develop prostatic epithelial hyperplasia and prostatic intraepithelial neoplasia (PIN) as early as 4.5 to 7 weeks of age

reproductive system

prostate gland epithelial hyperplasia ( J:120308 )

• mice develop prostatic epithelial hyperplasia as early as 4.5 to 7 weeks of age

increased prostate gland adenocarcinoma incidence ( J:120308 )

• the anterior prostate shows the most severe phenotype, followed by the dorsal-lateral and then ventral prostate

• small foci of tumor invasion into the stroma is seen but this is not common

• mice castrated at 6 weeks show regions of hyperplasia, and squamous metaplasia at 32 weeks later, but not carcinoma, indicating inhibition of tumor formation

• mice castrated after tumors still exhibit carcinoma 2 months postcastration

increased prostate intraepithelial neoplasia incidence ( J:120308 )

• mice develop prostatic epithelial hyperplasia and prostatic intraepithelial neoplasia (PIN) as early as 4.5 to 7 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:120308

Allelic Composition	Apc^tm1Tno/Apc⁺ Il23r^tm1.2Trin/Il23r^tm1.2Trin Tg(CDX2-cre)101Erf/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Il23r^tm1.2Trin mutation (0 available); any Il23r mutation (69 available)
Tg(CDX2-cre)101Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:189226 )

• reduced colorectal tumor multiplicity and grown compared to in Apc^tm1Tno/Apc⁺ Tg(CDX2-cre)101Erf mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(Cyp1a1-cre/ERT)1Dwi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:164579 )

• mice develop hyperplastic lesions in the bladder unlike wild-type mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Pten^tm1Hwu/Pten^tm1Hwu Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (89 available)
Tg(Cyp1a1-cre/ERT)1Dwi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:164579 )

• mice develop hyperplastic lesions in the bladder unlike wild-type mice that are larger than in Apc^tm1Tno/Apc^tm1Tno Tg(Cyp1a1-cre/ERT)1Dwi mice

Allelic Composition	Apc^tm1Tno/Apc⁺ Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:126018 )

• male and female animals display growth inhibition compared to controls

hematopoietic system

anemia ( J:126018 )

• mice exhibit severe anemia

neoplasm

increased gastrointestinal tumor incidence ( J:126018 )

• about 36 tumors are observed per mouse; most tumors are located in the small intestine

• cecal and colon tumors are small than those in age-matched in CDX2-cre/APC mice

increased small intestine adenocarcinoma incidence ( J:126018 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:126018 )

• about 36 tumors are observed per mouse; most tumors are located in the small intestine

• cecal and colon tumors are small than those in age-matched in CDX2-cre/APC mice

increased small intestine adenocarcinoma incidence ( J:126018 )

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Tg(CDX2-cre)101Erf/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(CDX2-cre)101Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:126018 )

• embryonic lethality is observed

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:126018 )

• embryonic lethality is observed

Allelic Composition	Apc^tm1Tno/Apc⁺ Tg(CDX2-cre)101Erf/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(CDX2-cre)101Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126018 )

• 36% (13/36) animals survived to 300 days of observation; 3 died and 20 were euthanized upon signs of distress

growth/size/body

decreased body weight ( J:126018 )

• males show inhibited weight gain after 120 days

neoplasm

increased tumor incidence ( J:126018 )

• mice show around 10 tumors

increased gastrointestinal tumor incidence ( J:126018 )

• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine

• colorectal tumors may be observed at early time points

• male mice have about 60% more colon tumors than controls

increased mammary adenocarcinoma incidence ( J:126018 )

• a small number of mice also develop mammary tumors

digestive/alimentary system

rectal prolapse ( J:126018 )

• greater than half the animals observed developed rectal prolapse with intermittent bleeding

increased gastrointestinal tumor incidence ( J:126018 )

• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine

• colorectal tumors may be observed at early time points

• male mice have about 60% more colon tumors than controls

intestinal obstruction ( J:126018 )

• some (3) animals died during the observation period from intestinal obstruction by tumor

hematopoietic system

anemia ( J:126018 )

• mice exhibit mild anemia

decreased hematocrit ( J:126018 )

• mice displaying mild anemia show hematocrits in range of 33 to 35% compared to around 45% in controls

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:126018 )

• a small number of mice also develop mammary tumors

integument

increased mammary adenocarcinoma incidence ( J:126018 )

• a small number of mice also develop mammary tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:126018

Allelic Composition	Apc^tm1Tno/Apc⁺ Tg(CDX2-cre*)189Erf/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(CDX2-cre*)189Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:148161 )

N	• mice show no signs of disease up to 200 days of age

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Tg(CDX2-cre*)189Erf/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(CDX2-cre*)189Erf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:148161 )

• animals live only 10-27 days past birth

postnatal lethality, complete penetrance ( J:148161 )

• animals live only 10-27 days past birth

neoplasm

increased colon adenoma incidence ( J:148161 )

• some mice show large numbers of polyploid lesions which show dysplastic adenomatous changes upon microscopic analysis

• in proximal colon, tubular adenomatous glands are observed in place of normal mucosa

digestive/alimentary system

increased colon adenoma incidence ( J:148161 )

• some mice show large numbers of polyploid lesions which show dysplastic adenomatous changes upon microscopic analysis

• in proximal colon, tubular adenomatous glands are observed in place of normal mucosa

intestine polyps ( J:148161 )

• all mice display florid polyposis in the proximal colon and cecum

limbs/digits/tail

short tail ( J:148161 )

• mice often display a short tail

kinked tail ( J:148161 )

• mice often display a crooked tail

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Tg(Cdh16-cre)91Igr/0
Genetic Background	involves: 129S4/SvJae * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Tg(Cdh16-cre)91Igr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:95502 )

• rare mice that survive to adulthood become moribund at 8-12 weeks of age

postnatal lethality, incomplete penetrance ( J:95502 )

• most mice die within 2-3 days of birth

• only 6 of 540 mice survive to weaning age

renal/urinary system

kidney cyst ( J:95502 )

• multiple kidney cysts are already noted at P2, involving both the nephrogenic zone and renal cortex

• at 8 weeks of age, kidney cysts include simple cysts lined by a single layer of epithelial cells, glomerular cysts, and multilayered cysts lined by a hyperplastic epithelium

• Ki67 staining revealed a dramatic increase in proliferation in the cyst wall epithelium

• kidney cysts are derived from multiple cell types including Bowman's capsule, proximal tubules, thick ascending limbs, distal convoluted tubules, and collecting ducts

• multilayered hyperplastic cysts display characteristics of neoplasia

• no loss of cilia in renal tubular epithelia is observed; however, large multilayered cysts show complete lack of cilia

polycystic kidney ( J:95502 )

• at 8 weeks of age, 6 of 6 mice display severe polycystic kidney disease

enlarged kidney ( J:95502 )

• at 8 weeks of age, kidneys are severely enlarged

increased renal cystadenoma incidence ( J:95502 )

• at 8 weeks of age, at least 2 of 6 mice show clear evidence of cystic renal adenoma

• however, no evidence of metastatic disease is observed in adult mice

growth/size/body

decreased body weight ( J:95502 )

• rare mice that survive to adulthood weigh 3-4 grams less than control littermates

kidney cyst ( J:95502 )

• multiple kidney cysts are already noted at P2, involving both the nephrogenic zone and renal cortex

• at 8 weeks of age, kidney cysts include simple cysts lined by a single layer of epithelial cells, glomerular cysts, and multilayered cysts lined by a hyperplastic epithelium

• Ki67 staining revealed a dramatic increase in proliferation in the cyst wall epithelium

• kidney cysts are derived from multiple cell types including Bowman's capsule, proximal tubules, thick ascending limbs, distal convoluted tubules, and collecting ducts

• multilayered hyperplastic cysts display characteristics of neoplasia

• no loss of cilia in renal tubular epithelia is observed; however, large multilayered cysts show complete lack of cilia

polycystic kidney ( J:95502 )

• at 8 weeks of age, 6 of 6 mice display severe polycystic kidney disease

enlarged kidney ( J:95502 )

• at 8 weeks of age, kidneys are severely enlarged

homeostasis/metabolism

increased blood urea nitrogen level ( J:95502 )

• BUN levels are significantly increased in early postnatal period (P2)

• BUN levels are also significantly increased in the rare mice that survive to adulthood

neoplasm

increased renal cystadenoma incidence ( J:95502 )

• at 8 weeks of age, at least 2 of 6 mice show clear evidence of cystic renal adenoma

• however, no evidence of metastatic disease is observed in adult mice

Allelic Composition	Apc^tm1Tno/Apc⁺ Brf1^tm1Arte/Brf1^tm1Arte Tg(Cyp1a1-cre)1Dwi/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Brf1^tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:285667 )

• mice develop similar tumor number and size as in Apc^tm1aTno Tg(Cyp1a1-cre)1Dwi heterozygotes

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:285667 )

• mice develop similar tumor number and size as in Apc^tm1aTno Tg(Cyp1a1-cre)1Dwi heterozygotes

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Ctnnb1^tm4.1Wbm mutation (0 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:156864 )

• no mutant mice (n=8) develope hepatocellular carcinomas by 450 days of age

Allelic Composition	Apc^Min/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Anterior head defects during embryonic development in Apc^Min/Apc^tm1Tno embryos and rescue of head defects by Ctnnb1^tm4.1Wbm/Ctnnb1⁺

liver/biliary system

increased hepatocellular carcinoma incidence ( J:156864 )

• hepatocellular carcinomas (HCC) in 47% of mutant mice (n=15), including 20% that showed intestinal comorbidity

• mice only have HCC (n=4) live longer than Apc^min/+ mice

nervous system

nervous system phenotype ( J:156864 )

N	• normal head morphology

craniofacial

craniofacial phenotype ( J:156864 )

N	• normal head morphology

digestive/alimentary system

intestine polyps ( J:156864 )

• reduced tumor multiplicity and incidence, leaving 6 of 15 mice (40%) free of polyps

• the remaining macroscopic lesions are of tubulo-villous structure

• similar size and latency to those observed in age-matched Apc^min/+ mice

neoplasm

increased hepatocellular carcinoma incidence ( J:156864 )

• hepatocellular carcinomas (HCC) in 47% of mutant mice (n=15), including 20% that showed intestinal comorbidity

• mice only have HCC (n=4) live longer than Apc^min/+ mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Pten^tm2Mak/Pten^tm2Mak
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:120955 )

• mice die within 19 weeks (range 7-19 weeks, average 11.5 weeks) after AdCre injection into the ovarian bursa and development of ovarian tumors

neoplasm

increased ovarian carcinoma incidence ( J:120955 )

• 8-10 week old mice injected with an adenovirus expressing cre recombinase (AdCre) into the right ovarian bursa develop ovarian carcinoma with 100% penetrance within 6 weeks of AdCre injection

• tumors show similarity to human ovarian endometrioid adenocarcinoma, with formation of distinct glands and occasional foci of squamous differentiation

endocrine/exocrine glands

increased ovarian carcinoma incidence ( J:120955 )

• 8-10 week old mice injected with an adenovirus expressing cre recombinase (AdCre) into the right ovarian bursa develop ovarian carcinoma with 100% penetrance within 6 weeks of AdCre injection

• tumors show similarity to human ovarian endometrioid adenocarcinoma, with formation of distinct glands and occasional foci of squamous differentiation

homeostasis/metabolism

hemorrhagic ascites ( J:120955 )

• 76% of ovarian bursa AdCre injected mice develop hemorrhagic ascites and 21% develop overt peritoneal dissemination of tumors

reproductive system

increased ovarian carcinoma incidence ( J:120955 )

• 8-10 week old mice injected with an adenovirus expressing cre recombinase (AdCre) into the right ovarian bursa develop ovarian carcinoma with 100% penetrance within 6 weeks of AdCre injection

• tumors show similarity to human ovarian endometrioid adenocarcinoma, with formation of distinct glands and occasional foci of squamous differentiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:120955

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