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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pnliprp2tm1Gru
targeted mutation 1, Michael J Grusby
MGI:1857970
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pnliprp2tm1Gru/Pnliprp2tm1Gru involves: 129S2/SvPas * BALB/c MGI:3041082


Genotype
MGI:3041082
hm1
Allelic
Composition		 Pnliprp2tm1Gru/Pnliprp2tm1Gru
Genetic
Background		 involves: 129S2/SvPas * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnliprp2tm1Gru mutation (0 available); any Pnliprp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal lipid absorption ( J:51627 )
• in suckling pups, not in adults
• lipid makes up 55% of dry weight of stools in pups as opposed to 7.5-10.6% in controls
• a high proportion of lipid in stools is diglycerides and triglycerides

growth/size/body
postnatal growth retardation ( J:51627 )
• rate of weight gain before weaning was slower than for controls

homeostasis/metabolism
abnormal intestinal lipid absorption ( J:51627 )
• in suckling pups, not in adults
• lipid makes up 55% of dry weight of stools in pups as opposed to 7.5-10.6% in controls
• a high proportion of lipid in stools is diglycerides and triglycerides

immune system
decreased cytotoxic T cell cytolysis ( J:51627 )
• cytotoxicity of immunized splenocytes significantly reduced

hematopoietic system
decreased cytotoxic T cell cytolysis ( J:51627 )
• cytotoxicity of immunized splenocytes significantly reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory