Phenotypes associated with this allele

• Allele Symbol: Grm4^tm1Hpn
• Allele Name: targeted mutation 1, David R Hampson
• Allele ID: MGI:1857980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm4^tm1Hpn/Grm4^tm1Hpn	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2176742

Genotype
MGI:2176742

hm1

• Allelic Composition: Grm4^tm1Hpn/Grm4^tm1Hpn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor learning ( J:35793 )

• homozygotes improve less with training in the rotating rod motor-learning test compared to wild-type mice; however performance in the open field and bar crossing tests is similar to wild-type

nervous system

decreased post-tetanic potentiation ( J:35793 )

• conditions that stimulate post-tetanic potentiation in wild-type mice induce only post-tetanic depression in most homozygous Purkinje cells

decreased paired-pulse facilitation ( J:35793 )

• paired pulse facilitation is significantly reduced st all interstimulus intervals examined and at greater than 300msec intervals the amplitude of the second EPSC is depressed rather than facilitated as in wild-type mice

• however, long term depression is similar to wild-type