Phenotypes associated with this allele

• Allele Symbol: Grm7^tm1Nak
• Allele Name: targeted mutation 1, Shigetada Nakanishi
• Allele ID: MGI:1857984
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm7^tm1Nak/Grm7^tm1Nak	B6.129P2-Grm7^tm1Nak	MGI:7430705
hm2	Grm7^tm1Nak/Grm7^tm1Nak	involves: 129P2/OlaHsd * C57BL/6	MGI:2176776

Genotype
MGI:7430705

hm1

• Allelic Composition: Grm7^tm1Nak/Grm7^tm1Nak
• Genetic Background: B6.129P2-Grm7^tm1Nak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:332705 )

♂N • sexually inexperienced, gonadally intact males exhibit normal erectile function

reduced male fertility ( J:332705 )

abnormal ejaculation ( J:332705 )

♂ • when the observation time is extended to 2h in a sexual behavior test, only one male ejaculated 77 min after entering a female in the sixth trial whereas all wild-type males ejaculated within 35 min

failure of ejaculation ( J:332705 )

♂ • no male mice ejaculated during a 30-min test period whereas >60% of wild-type males achieved ejaculation in the third to sixth trials

behavior/neurological

behavior/neurological phenotype ( J:332705 )

♂N • during a 30-min period of pairing with hormone-primed females, males show no significant differences in the mean duration of anogenital sniffing or mounting behavior relative to wild-type males, indicating normal sexual motivation

abnormal sexual interaction ( J:332705 )

♂ • some male mice exhibit a relatively long duration of thrusting behavior, while others show no thrusting behavior or give up after a short time

♂ • moreover, a drastic shift is observed from non-thrusting to thrusting behavior

abnormal intromission ( J:332705 )

♂ • during 30-min pairing, the mean duration of intromissions is significantly shorter in the first and second trials but reaches almost wild-type levels in the third to sixth trials

Genotype
MGI:2176776

hm2

• Allelic Composition: Grm7^tm1Nak/Grm7^tm1Nak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal conditioned taste aversion behavior ( J:52411 )

• mice do not exhibit taste aversion behavior following conditioning with lithium chloride injection

• however, taste preferences and sensitivity to lithium chloride are normal

abnormal contextual conditioning behavior ( J:52411 )

• mice exhibit reduced freezing compared to wild-type mice in response to a fear stimuli

• however, pain sensitivity and motor processing capacities are normal

seizures ( J:52411 )

• mice older than 12 weeks exhibit epilepsy, particularly when placed into a new chamber

nervous system

seizures ( J:52411 )

• mice older than 12 weeks exhibit epilepsy, particularly when placed into a new chamber