Phenotypes associated with this allele

• Allele Symbol: Grm1^tm1Crpl
• Allele Name: targeted mutation 1, Francis Crepel
• Allele ID: MGI:1857986
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm1^tm1Crpl/Grm1^tm1Crpl	involves: 129P2/OlaHsd * C57BL/6	MGI:2176844
hm2	Grm1^tm1Crpl/Grm1^tm1Crpl	Not Specified	MGI:3575752

Genotype
MGI:2176844

hm1

• Allelic Composition: Grm1^tm1Crpl/Grm1^tm1Crpl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:21644 )

• significant reduction in total distance traveled in a new environment

abnormal spatial learning ( J:21644 )

• inability to locate platform in hidden-platform task of Morris Water Maze

• in the visible-platform task, initially take longer to reach the platform, but after 3 sessions are as fast as controls

impaired righting response ( J:21644 )

• complete loss of righting reflex by Irwin screening

tremors ( J:21644 )

• between the second and third week after birth, action tremor and errors in metric of movements become evident

ataxia ( J:21644 )

• evident beginning between the second and third week after birth, exhibit impaired balance and a wide-based standing position

nervous system

reduced long-term potentiation ( J:21644 )

• impaired hippocampal mossy fiber long-term potentiation, however no gross anatomical abnormalities in the hippocampus, cerebellum, or elsewhere, no detectable defects in active or passive membrane properties or synaptic responses of the cerebellum, and normal electrophysiology of hippocampus

reduced long-term depression ( J:21644 )

• impaired cerebellar long-term depression

Genotype
MGI:3575752

hm2

• Allelic Composition: Grm1^tm1Crpl/Grm1^tm1Crpl
• Genetic Background: Not Specified

nervous system

reduced long-term potentiation ( J:97042 )

• amplitude of corticostriatal long term potentiation is significantly reduced

• corticostriatal long term potentiation is completely blocked when MPEP, a Grm5 antoagonist, is added