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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou3f1tm1Rsd
targeted mutation 1, Michael G Rosenfeld
MGI:1857994
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pou3f1tm1Rsd/Pou3f1tm1Rsd either: (involves: 129S4/SvJae * 129/Sv * C57BL/6J) or (involves: 129S4/SvJae * C57BL/6 * C57BL/6J) MGI:2655754
hm2
 		Pou3f1tm1Rsd/Pou3f1tm1Rsd involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:2665327
cx3
 		Pou2f3tm1Rsd/Pou2f3tm1Rsd
Pou3f1tm1Rsd/Pou3f1tm1Rsd 		involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:2665472


Genotype
MGI:2655754
hm1
Allelic
Composition		 Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic
Background		 either: (involves: 129S4/SvJae * 129/Sv * C57BL/6J) or (involves: 129S4/SvJae * C57BL/6 * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:34460 )
• rare animals survive up to 22 days
neonatal lethality, incomplete penetrance ( J:34460 )
• most mice die within 2 hours of birth; death attributed to respiratory failure

homeostasis/metabolism
cyanosis ( J:34460 )
• pups were cyanotic at birth

respiratory system
respiratory failure ( J:34460 )
• death attributed to respiratory failure

nervous system
abnormal olfactory tract morphology ( J:34460 )
• the nucleus of the lateral olfactory tract is displaced in P0 brains and displaced, and diminished or missing in P4 brains
abnormal phrenic nerve morphology ( J:34460 )
• abnormalities in position and number of phrenic motoneurons
abnormal sciatic nerve morphology ( J:34460 )
• few axons in the sciatic nerve were myelinated
abnormal myelination ( J:34460 )
• most myelinating Schwann cells failed to mature beyond the ensheathment stage

integument
integument phenotype ( J:34460 )
N
• skin appeared grossly normal




Genotype
MGI:2665327
hm2
Allelic
Composition		 Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:34460 )
• rare animals survive up to 22 days




Genotype
MGI:2665472
cx3
Allelic
Composition		 Pou2f3tm1Rsd/Pou2f3tm1Rsd
Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f3tm1Rsd mutation (0 available); any Pou2f3 mutation (34 available)
Pou3f1tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:42016 )
• most mice die soon after birth

integument
integument phenotype ( J:42016 )
N
• no overt skin abnormalities in neonates




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory