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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zp1tm1Dean
targeted mutation 1, Jurrien Dean
MGI:1857997
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zp1tm1Dean/Zp1tm1Dean involves: 129S1/Sv * 129X1/SvJ * CF-1 MGI:2653161


Genotype
MGI:2653161
hm1
Allelic
Composition		 Zp1tm1Dean/Zp1tm1Dean
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CF-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zp1tm1Dean mutation (1 available); any Zp1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal granulosa cell morphology ( J:56560 )
• in some cases ectopic localization of granulosa cells in the perivitelline space was observed
abnormal ovarian folliculogenesis ( J:56560 )
• gross attenuation of the perivitelline space between the egg and the zona matrix
• in some cases ectopic localization of granulosa cells in the perivitelline space was observed

reproductive system
abnormal zona pellucida morphology ( J:56560 )
• thinning and disorganization of zona pellucida
• larger fenestrations in the zona pellucida
• eggs with both normal and distorted zonae were ovulated, but only eggs with intact zonae progressed to the 2-cell stage, and implanted in the uterus
abnormal granulosa cell morphology ( J:56560 )
• in some cases ectopic localization of granulosa cells in the perivitelline space was observed
abnormal ovarian folliculogenesis ( J:56560 )
• gross attenuation of the perivitelline space between the egg and the zona matrix
• in some cases ectopic localization of granulosa cells in the perivitelline space was observed
abnormal reproductive system physiology ( J:56560 )
• normal ovulation
• increased number of sperm bound to zona relative to wild-type
reduced female fertility ( J:56560 )
• 80% of females were fertile
decreased litter size ( J:56560 )
• fertile females gave birth litters approximately half the normal size

cellular
abnormal zona pellucida morphology ( J:56560 )
• thinning and disorganization of zona pellucida
• larger fenestrations in the zona pellucida
• eggs with both normal and distorted zonae were ovulated, but only eggs with intact zonae progressed to the 2-cell stage, and implanted in the uterus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory