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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hoxa1tm2Mrc
targeted mutation 2, Mario R Capecchi
MGI:1858002
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hoxa1tm1Mrc/Hoxa1tm2Mrc
Hoxa2tm1Mrc/Hoxa2+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:2170580
cx2
Hoxa1tm2Mrc/Hoxa1tm2Mrc
Hoxa2tm1Mrc/Hoxa2tm1Mrc
involves: 129S1/Sv * 129X1/SvJ MGI:2170585
cx3
Hoxa1tm2Mrc/Hoxa1+
Hoxa2tm1Mrc/Hoxa2tm1Mrc
involves: 129S1/Sv * 129X1/SvJ MGI:3043810
cx4
Hoxa1tm2Mrc/Hoxa1+
Hoxa2tm1Mrc/Hoxa2+
involves: 129S1/Sv * 129X1/SvJ MGI:3043811


Genotype
MGI:2170580
cx1
Allelic
Composition
Hoxa1tm1Mrc/Hoxa1tm2Mrc
Hoxa2tm1Mrc/Hoxa2+
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm1Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa1tm2Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa2tm1Mrc mutation (0 available); any Hoxa2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die shortly after birth

craniofacial
• slight restructuring and reduced ossification
• absence of the stapes in many cases
• reduced middle ear apparatus
• reduced pinna of ear

hearing/vestibular/ear
• absence of the stapes in many cases
• reduced middle ear apparatus
• reduced pinna of ear

respiratory system
• never initiate normal breathing patterns resulting in rapid death

skeleton
• slight restructuring and reduced ossification
• absence of the stapes in many cases
• reduced middle ear apparatus

growth/size/body
• reduced pinna of ear




Genotype
MGI:2170585
cx2
Allelic
Composition
Hoxa1tm2Mrc/Hoxa1tm2Mrc
Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm2Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa2tm1Mrc mutation (0 available); any Hoxa2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die shortly after birth

hearing/vestibular/ear
• severe patterning defects in the middle ear and associated skeleton
• reduced size of middle ear elements
• pinna of ear almost entirely absent

skeleton
• severe patterning defects in the middle ear and associated skeleton
• reduced size of middle ear elements

nervous system
• extensive hindbrain defects affecting breathing

craniofacial
• severe patterning defects in the middle ear and associated skeleton
• reduced size of middle ear elements
• pinna of ear almost entirely absent

growth/size/body
• pinna of ear almost entirely absent




Genotype
MGI:3043810
cx3
Allelic
Composition
Hoxa1tm2Mrc/Hoxa1+
Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm2Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa2tm1Mrc mutation (0 available); any Hoxa2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die shortly after birth of dehydration

behavior/neurological
• unable to suckle

craniofacial
• extent of cleft secondary palate not as great with decreased functional Hoxa1

digestive/alimentary system
• extent of cleft secondary palate not as great with decreased functional Hoxa1

growth/size/body
• extent of cleft secondary palate not as great with decreased functional Hoxa1




Genotype
MGI:3043811
cx4
Allelic
Composition
Hoxa1tm2Mrc/Hoxa1+
Hoxa2tm1Mrc/Hoxa2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm2Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa2tm1Mrc mutation (0 available); any Hoxa2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory