Phenotypes associated with this allele

• Allele Symbol: Krt19^tm1(cre)Mmt
• Allele Name: targeted mutation 1, Makoto M Taketo
• Allele ID: MGI:1858007
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox9^tm1Gsr/Sox9^tm1Gsr Krt19^tm1(cre)Mmt/Krt19^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3639700
cn2	Flt4^tm1Ali/Flt4^tm2.1Ali Krt19^tm1(cre)Mmt/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL	MGI:3805321
cn3	Ctnnb1^tm1Mmt/Ctnnb1^+ Krt19^tm1(cre)Mmt/Krt19^+	involves: 129X1/SvJ	MGI:2673257

Genotype
MGI:3639700

cn1

• Allelic Composition: Sox9^tm1Gsr/Sox9^tm1Gsr; Krt19^tm1(cre)Mmt/Krt19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:104330 )

• recover only about 1/8 of the expected number of embryos after E11.5, however some survive up to E15.5

reproductive system

abnormal testis development ( J:104330 )

• failure of testis differentiation is apparent at E12.5

absent testis cords ( J:104330 )

• lack of testis cord formation

absent Leydig cells ( J:104330 )

• Leydig cells do not form

primary sex reversal ( J:104330 )

• XY gonads up to E15.5 show immediate complete sex reversal as indicated by the expression of early ovary-specific markers and lack of testis cord and Leydig cell formation

• 2 of 11 embryos form a completely sex-reversed gonad on one side and an ovotestis on the contralateral side

cardiovascular system

heart hypoplasia ( J:104330 )

skeleton

abnormal cartilage development ( J:104330 )

• display a reduction in all cartilage anlagen

endocrine/exocrine glands

abnormal testis development ( J:104330 )

• failure of testis differentiation is apparent at E12.5

absent testis cords ( J:104330 )

• lack of testis cord formation

absent Leydig cells ( J:104330 )

• Leydig cells do not form

embryo

failure of Mullerian duct regression ( J:104330 )

• absence of Mullerian duct regression in males

impaired cranial neural crest cell differentiation ( J:104330 )

• display a reduction in cranial neural crest cell-derived tissue

nervous system

impaired cranial neural crest cell differentiation ( J:104330 )

• display a reduction in cranial neural crest cell-derived tissue

Genotype
MGI:3805321

cn2

• Allelic Composition: Flt4^tm1Ali/Flt4^tm2.1Ali; Krt19^tm1(cre)Mmt/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137909 )

• phenotype is stated to be identical to that of Flt^tm1Ali homozygotes

cardiovascular system

abnormal blood vessel morphology ( J:137909 )

• blood vessel defects identical to those in Flt^tm1Ali homozygotes

Genotype
MGI:2673257

cn3

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Krt19^tm1(cre)Mmt/Krt19⁺
• Genetic Background: involves: 129X1/SvJ

mortality/aging

premature death ( J:58367 )

• died around 3 months of age of anemia and cachexia

neoplasm

increased intestinal adenoma incidence ( J:58367 )

• more than 3000 intestinal polyps/mouse by 3 weeks of age

• primarily in the duodenum and proximal jejunum

• lower densities in the ileum

• microadenomas in the colon

digestive/alimentary system

increased intestinal adenoma incidence ( J:58367 )

• more than 3000 intestinal polyps/mouse by 3 weeks of age

• primarily in the duodenum and proximal jejunum

• lower densities in the ileum

• microadenomas in the colon