All Phenotypes Pik3cg<tm1Dwu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3cg^tm1Dwu/Pik3cg^tm1Dwu	B6.Cg-Pik3cg^tm1Dwu	MGI:4358172
hm2	Pik3cg^tm1Dwu/Pik3cg^tm1Dwu	Not Specified	MGI:4358151
cx3	Apoe^tm1Unc/Apoe^tm1Unc Pik3cg^tm1Dwu/Pik3cg^tm1Dwu	B6.Cg-Apoe^tm1Unc Pik3cg^tm1Dwu	MGI:4358191
cx4	Pik3cg^tm1Dwu/Pik3cg^tm1Dwu Tg(TcraTcrb)1100Mjb/0	involves: C57BL/6	MGI:4358198

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:131923 )

• at high viral titers of vaccinia virus, mice exhibit rapid weight loss, become ill, and die within 5 days unlike similarly treated wild-type mice

immune system

immune system phenotype ( J:131923 )

N	• naive CD8+ T cell migration, activation, proliferation, and differentiation are normal

decreased CD8-positive, alpha-beta T cell number ( J:131923 )

• fewer resident CD8+ T cells are detected in the peritoneum compared to in wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:131923 )

• CD8+ T cell migration in vitro in response to LTB4 and CCL5 is reduced compared with wild-type cells

• CD8+ T cell impaired migration in response to LTB4 is more severe than for CCL5

• however, migration in response to CCl21 is normal

abnormal response to infection ( J:131923 )

• following infection with VV-WR (vaccinia virus- Western Reserve strain), mice exhibit reduced influx of CD8+ T and NK cells into the peritoneum compared to in similarly treated wild-type mice

increased susceptibility to Poxviridae infection ( J:131923 )

• at high viral titers of vaccinia virus, mice exhibit rapid weight loss, become ill, and die within 5 days unlike similarly treated wild-type mice

homeostasis/metabolism

decreased platelet calcium level ( J:107460 )

• thrombin-stimulated calcium mobilization in platelets is 25% less than in similarly treated wild-type cells

abnormal platelet physiology ( J:107460 )

• spreading of platelets on fibrinogen is impaired compared with wild-type cells

• however, platelet granule secretion is normal

decreased platelet aggregation ( J:107460 )

• when stimulated with low concentrations of ADP or collagen

decreased susceptibility to induced thrombosis ( J:107460 )

• following ferric chloride-induced arterial injury, mice fail to form arterial occlusions or form weak occlusions unlike in similarly treated wild-type mice

hematopoietic system

decreased platelet calcium level ( J:107460 )

• thrombin-stimulated calcium mobilization in platelets is 25% less than in similarly treated wild-type cells

decreased CD8-positive, alpha-beta T cell number ( J:131923 )

• fewer resident CD8+ T cells are detected in the peritoneum compared to in wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:131923 )

• CD8+ T cell migration in vitro in response to LTB4 and CCL5 is reduced compared with wild-type cells

• CD8+ T cell impaired migration in response to LTB4 is more severe than for CCL5

• however, migration in response to CCl21 is normal

abnormal platelet physiology ( J:107460 )

• spreading of platelets on fibrinogen is impaired compared with wild-type cells

• however, platelet granule secretion is normal

decreased platelet aggregation ( J:107460 )

• when stimulated with low concentrations of ADP or collagen

growth/size/body

weight loss ( J:131923 )

• at high viral titers of vaccinia virus

Allelic Composition	Pik3cg^tm1Dwu/Pik3cg^tm1Dwu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cg^tm1Dwu mutation (1 available); any Pik3cg mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil chemotaxis ( J:60348 )

• in response to fMLP (formyl peptide N-formyl-Met-Leu-Phe) or MIP-1alpha (Ccl3), neutrophil migration is impaired in an in vitro migration assay compared with similarly treated wild-type cells

• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is impaired compared to in similarly treated wild-type mice

decreased immunoglobulin level ( J:60348 )

• mice treated with NP-Ficoll produce fewer antibodies containing lambda light chain compared with similarly treated wild-type mice

cellular

impaired neutrophil chemotaxis ( J:60348 )

• in response to fMLP (formyl peptide N-formyl-Met-Leu-Phe) or MIP-1alpha (Ccl3), neutrophil migration is impaired in an in vitro migration assay compared with similarly treated wild-type cells

• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is impaired compared to in similarly treated wild-type mice

hematopoietic system

impaired neutrophil chemotaxis ( J:60348 )

• in response to fMLP (formyl peptide N-formyl-Met-Leu-Phe) or MIP-1alpha (Ccl3), neutrophil migration is impaired in an in vitro migration assay compared with similarly treated wild-type cells

• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is impaired compared to in similarly treated wild-type mice

decreased immunoglobulin level ( J:60348 )

• mice treated with NP-Ficoll produce fewer antibodies containing lambda light chain compared with similarly treated wild-type mice

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Pik3cg^tm1Dwu/Pik3cg^tm1Dwu
Genetic Background	B6.Cg-Apoe^tm1Unc Pik3cg^tm1Dwu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (152 available)
Pik3cg^tm1Dwu mutation (1 available); any Pik3cg mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:121582 )

• atherosclerotic lesions are reduced 52% at 35 weeks, 32% at 53 weeks, and 36% at 60 weeks compared to in Apoe^tm1Unc homozygotes

homeostasis/metabolism

decreased circulating cholesterol level ( J:121582 )

• total and non-HDL cholesterol after 60 weeks compared to in Apoe^tm1Unc homozygotes

Allelic Composition	Pik3cg^tm1Dwu/Pik3cg^tm1Dwu Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cg^tm1Dwu mutation (1 available); any Pik3cg mutation (59 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:131923 )

N	• naive CD8+ T cell activation, proliferation, and differentiation are normal

abnormal CD8-positive, alpha-beta T cell physiology ( J:131923 )

• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host

• however, 4 days after infection CD8+ T cell numbers are normal

abnormal response to infection ( J:131923 )

• however, 4 days after infection CD8+ T cell numbers are normal

hematopoietic system

abnormal CD8-positive, alpha-beta T cell physiology ( J:131923 )

• however, 4 days after infection CD8+ T cell numbers are normal

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