All Phenotypes Msh6<tm1Rak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Msh6^tm1Rak
targeted mutation 1, Raju Kucherlapati
MGI:1858014

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msh6^tm1Rak/Msh6^tm1Rak	involves: 129/Sv * C57BL/6J * SJL	MGI:2183380
cx2	Msh3^tm1Rak/Msh3^tm1Rak Msh6^tm1Rak/Msh6^tm1Rak	involves: 129/Sv * C57BL/6J * SJL	MGI:2183371

Allelic Composition	Msh6^tm1Rak/Msh6^tm1Rak
Genetic Background	involves: 129/Sv * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh6^tm1Rak mutation (1 available); any Msh6 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:44428 )

• 40% dead by 9 months of age

• 65% dead by 12 months of age

• 92% dead by 15 months of age

• median survival time was 10 months

neoplasm

increased tumor incidence ( J:44428 )

• 92% of mice develop a spectrum of tumors, but predominantly GI tumors and T- and B-cell lymphomas

increased gastrointestinal tumor incidence ( J:44428 )

increased lymphoma incidence ( J:44428 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:44428 )

Allelic Composition	Msh3^tm1Rak/Msh3^tm1Rak Msh6^tm1Rak/Msh6^tm1Rak
Genetic Background	involves: 129/Sv * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh3^tm1Rak mutation (1 available); any Msh3 mutation (61 available)
Msh6^tm1Rak mutation (1 available); any Msh6 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:60604 )

• 50% moribund or morbid by 5 - 6 months of age

neoplasm

increased gastrointestinal tumor incidence ( J:60604 )

• mice develop predominantly GI tumors

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 12 of 16 mice

increased lymphoma incidence ( J:60604 )

• non-Hodgkin's lymphomas

cellular

abnormal mismatch repair ( J:60604 )

• cells lack mismatch repair

homeostasis/metabolism