Phenotypes associated with this allele

• Allele Symbol: Met^tm2Cpo
• Allele Name: targeted mutation 2, Carola Ponzetto
• Allele ID: MGI:1858021
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Met^tm2Cpo/Met^tm2Cpo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2450975
ht2	Met^tm4Cpo/Met^tm2Cpo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2450970
ht3	Met^tm2Cpo/Met^tm4.1Cpo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2450971
ht4	Met^tm1Cpo/Met^tm2Cpo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2450977

Genotype
MGI:2450975

hm1

• Allelic Composition: Met^tm2Cpo/Met^tm2Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:36244 )

• most animals die within a few hours after birth

growth/size/body

postnatal growth retardation ( J:36244 )

• animals surviving past postnatal day 1 display growth retardation during first week

limbs/digits/tail

abnormal forelimb morphology ( J:36244 )

• hyperflexed forelimbs

muscle

decreased skeletal muscle mass ( J:36244 )

• animals surviving past postnatal day 1 display reduced limb muscle mass

behavior/neurological

paraparesis ( J:36244 )

• hindlimb weakness

Genotype
MGI:2450970

ht2

• Allelic Composition: Met^tm4Cpo/Met^tm2Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

mortality/aging

neonatal lethality, complete penetrance ( J:81793 )

• death within a few hours after birth

limbs/digits/tail

abnormal forelimb morphology ( J:81793 )

• hyperflexed forelimbs

Genotype
MGI:2450971

ht3

• Allelic Composition: Met^tm2Cpo/Met^tm4.1Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

behavior/neurological

impaired coordination ( J:81793 )

• impaired motor coordination in thin rod test

nervous system

abnormal neuron differentiation ( J:81793 )

• 25% decrease in granule cell proliferation

reduced cerebellar foliation ( J:81793 )

• reduced or absent fissures in declival sulcus and intercrural fissure

• reduction of secondary and posterolateral fissures

small cerebellum ( J:81793 )

• cerebellar weight reduced by 20%

cellular

abnormal neuron differentiation ( J:81793 )

• 25% decrease in granule cell proliferation

Genotype
MGI:2450977

ht4

• Allelic Composition: Met^tm1Cpo/Met^tm2Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

mortality/aging

neonatal lethality, complete penetrance ( J:36244 )

• animals die within a few minutes after birth due to respiratory failure

• animals display curled fetal position

muscle

decreased skeletal muscle mass ( J:36244 )

• reduced total muscle mass

respiratory system

respiratory failure ( J:36244 )