All Phenotypes Cryaa<tm1Wawr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cryaa^tm1Wawr
targeted mutation 1, Eric F Wawrousek
MGI:1858025

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cryaa^tm1Wawr/Cryaa^tm1Wawr	involves: 129/Sv * 129S4/SvJae	MGI:2175799
hm2	Cryaa^tm1Wawr/Cryaa^tm1Wawr	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:2175800
ht3	Cryaa^tm1Wawr/Cryaa⁺	involves: 129/Sv * 129S4/SvJae	MGI:2681051
ht4	Cryaa^tm1Wawr/Cryaa⁺	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:2681049

Allelic Composition	Cryaa^tm1Wawr/Cryaa^tm1Wawr
Genetic Background	involves: 129/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaa^tm1Wawr mutation (0 available); any Cryaa mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lens opacity in Cryaa^tm1Wawr/Cryaa^tm1Wawr mice

vision/eye

increased lens epithelium apoptosis ( J:38210 )

• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

cataract ( J:38210 )

• mild cataract at 7 weeks of age; progressive severity to dense opacity by 10 weeks of age

small lens ( J:38210 )

• small lens; 25-35% reduced weight and 15% reduced axial and equatorial dimensions

• inclusion bodies composed of crystallin proteins observed in nuclear and inner cortical regions

microphthalmia ( J:38210 )

• small eyes

cellular

increased lens epithelium apoptosis ( J:38210 )

• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:38210

Allelic Composition	Cryaa^tm1Wawr/Cryaa^tm1Wawr
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaa^tm1Wawr mutation (0 available); any Cryaa mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lens opacity in Cryaa^tm1Wawr/Cryaa^tm1Wawr mice

vision/eye

increased lens epithelium apoptosis ( J:82601 )

• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

cataract ( J:38210 )

• mild cataract at 7 weeks of age; progressive severity to dense opacity by 10 weeks of age

small lens ( J:38210 )

• small lens; 25-35% reduced weight and 15% reduced axial and equatorial dimensions

• inclusion bodies composed of crystallin proteins observed in nuclear and inner cortical regions

microphthalmia ( J:38210 )

• small eyes

cellular

increased lens epithelium apoptosis ( J:82601 )

• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:38210

Allelic Composition	Cryaa^tm1Wawr/Cryaa⁺
Genetic Background	involves: 129/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaa^tm1Wawr mutation (0 available); any Cryaa mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

small lens ( J:38210 )

• small lens; 10-15% reduced weight and 5% reduced axial and equatorial dimensions

Allelic Composition	Cryaa^tm1Wawr/Cryaa⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaa^tm1Wawr mutation (0 available); any Cryaa mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

small lens ( J:38210 )

• small lens; 10-15% reduced weight and 5% reduced axial and equatorial dimensions

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