Phenotypes associated with this allele

• Allele Symbol: Scd1^ab-2J
• Allele Name: asebia 2 Jackson
• Allele ID: MGI:1858029
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scd1^ab-2J/Scd1^ab-2J	DBA/1LacJ-Scd1^ab-2J/J	MGI:3794973
cx2	Ldlr^tm1Her/Ldlr^tm1Her Scd1^ab-2J/Scd1^ab-2J	B6.Cg-Ldlr^tm1Her Scd1^ab-2J	MGI:3794980

Genotype
MGI:3794973

hm1

• Allelic Composition: Scd1^ab-2J/Scd1^ab-2J
• Genetic Background: DBA/1LacJ-Scd1^ab-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased fluid intake ( J:62699 )

hunched posture ( J:62699 )

homeostasis/metabolism

impaired skin barrier function ( J:62699 )

• transepidermal water loss is increased 4.5-fold compared to in wild-type mice

abnormal lipid level ( J:62699 )

• mice exhibit a reduction in skin surface lipids such as sterol esters and cholesterol with a total loss of diol esters unlike in wild-type mice

immune system

granulomatous inflammation ( J:62699 )

• hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle

renal/urinary system

polyuria ( J:62699 )

• urine output is increased by 2% compared to in wild-type mice

endocrine/exocrine glands

abnormal sebocyte morphology ( J:62699 )

• although some early sebaceous differentiation occurs, sebocytes appear small and their cytoplasm is brightly eosinophilic, unlike wild-type cells

small Meibomian gland ( J:62699 )

• small

small sebaceous gland ( J:62699 )

• at day 6 mice have very small sebaceous glands compared to in wild-type mice

• mice have small Meibomian, perianal and cerimous glands

• however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal

small perianal sebaceous gland ( J:62699 )

sebaceous gland hypoplasia ( J:62699 )

• extreme sebaceous gland hypoplasia

vision/eye

small Meibomian gland ( J:62699 )

• small

integument

abnormal sebocyte morphology ( J:62699 )

• although some early sebaceous differentiation occurs, sebocytes appear small and their cytoplasm is brightly eosinophilic, unlike wild-type cells

small sebaceous gland ( J:62699 )

• at day 6 mice have very small sebaceous glands compared to in wild-type mice

• mice have small Meibomian, perianal and cerimous glands

• however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal

small perianal sebaceous gland ( J:62699 )

sebaceous gland hypoplasia ( J:62699 )

• extreme sebaceous gland hypoplasia

impaired skin barrier function ( J:62699 )

• transepidermal water loss is increased 4.5-fold compared to in wild-type mice

sparse hair ( J:62699 )

matted coat ( J:62699 )

abnormal hair shaft morphology ( J:62699 )

• hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle

abnormal hair follicle morphology ( J:62699 )

• hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle

abnormal hair follicle bulb morphology ( J:62699 )

• hair follicle bulbar histology is distorted compared to in wild-type mice

abnormal hair follicle inner root sheath morphology ( J:62699 )

• the inner root sheath is retained beyond the midfollicle into the outer piliary canal unlike in wild-type mice

enlarged hair follicles ( J:62699 )

• during the first anagen stage the hair follicles are unusually long and extend at a sharp angle into the deep subcutis unlike in wild-type mice

abnormal hair cycle ( J:62699 )

• follicles stay in anagen longer than in wild-type mice

• while few follicles continue to cycle, with each cycle there is a progressive loss of individual follicles

abnormal skin morphology ( J:62699 )

• mice exhibit thicker than normal epidermis, Malphigian layer and stratum corneum

small Meibomian gland ( J:62699 )

• small

thick dermal layer ( J:62699 )

orthokeratosis ( J:62699 )

• mice exhibit varying degrees of orthokeratotic hyperkeratosis

parakeratosis ( J:62699 )

• in focal areas

acanthosis ( J:62699 )

thick epidermis ( J:62699 )

dry skin ( J:62699 )

flaky skin ( J:62699 )

• moderate white flaking is observed when hair is removed unlike in wild-type mice

scaly skin ( J:62699 )

Genotype
MGI:3794980

cx2

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Scd1^ab-2J/Scd1^ab-2J
• Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J

Adiposity in Ldlr^tm1Her/Ldlr^tm1Her and Scd1^ab-2J/Scd1^ab-2J Ldlr^tm1Her/Ldlr^tm1Her mice

adipose tissue

abnormal fat pad morphology ( J:130278 )

abnormal epididymal fat pad morphology ( J:130278 )

• when fed a western style diet for 12 weeks, male mice have smaller periepididymal fat pads than Ldlr^tm1Her homozygotes

abnormal uterine fat pad morphology ( J:130278 )

• when fed a western style diet for 12 weeks, female mice have smaller periuterine fat pads than Ldlr^tm1Her homozygotes

decreased percent body fat/body weight ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlr^tm1Her homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:130278 )

N • when fed a western style diet for 12 weeks, mice are protected from impaired glucose tolerance, hyperglycemia, and increased plasma insulin levels observed in Ldlr^tm1Her homozygotes

abnormal lipid level ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a decrease in visceral and subcutaneous lipid compared to in Ldlr^tm1Her homozygotes

abnormal circulating cholesterol level ( J:130278 )

• when fed a western style diet for 12 weeks, male mice exhibit a lower circulating cholesterol level than in Ldlr^tm1Her homozygotes

decreased circulating VLDL cholesterol level ( J:130278 )

• compared to in Ldlr^tm1Her homozygotes when fed a western style diet for 12 weeks

abnormal triglyceride level ( J:130278 )

decreased circulating triglyceride level ( J:130278 )

• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlr^tm1Her homozygotes

decreased circulating VLDL triglyceride level ( J:130278 )

• compared to in Ldlr^tm1Her homozygotes when fed a western style diet for 12 weeks

decreased liver triglyceride level ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlr^tm1Her homozygotes

behavior/neurological

increased food intake ( J:130278 )

• when fed a western style diet for 12 weeks, mice consuming more food than Ldlr^tm1Her homozygotes

growth/size/body

slow postnatal weight gain ( J:130278 )

• when fed a western style diet for 12 weeks, mice gain less weight than Ldlr^tm1Her homozygotes despite consuming more food

liver/biliary system

liver/biliary system phenotype ( J:130278 )

N • when fed a western style diet for 12 weeks, mice are protected from the hepatic steatosis observed in Ldlr^tm1Her homozygotes

decreased liver triglyceride level ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlr^tm1Her homozygotes