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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nek1kat
kidney, anemia and testis
MGI:1858030
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nek1kat/Nek1kat B6.RBF(C3Fe)-Nek1kat/J MGI:3831371
hm2
Nek1kat/Nek1kat involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn MGI:3831332
hm3
Nek1kat/Nek1kat involves: C3HeB/FeJLe * RBF/Dn MGI:3831295
hm4
Nek1kat/Nek1kat involves: RBF/Dn MGI:3831294


Genotype
MGI:3831371
hm1
Allelic
Composition
Nek1kat/Nek1kat
Genetic
Background
B6.RBF(C3Fe)-Nek1kat/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation (1 available); any Nek1 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: by generation N5 on the C57BL/6J background half of the homozygotes die before weaning

growth/size/body
• by generation N5 to C57BL/6J there is increased severity of the phenotype including severe dwarfing

craniofacial

skeleton




Genotype
MGI:3831332
hm2
Allelic
Composition
Nek1kat/Nek1kat
Genetic
Background
involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation (1 available); any Nek1 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 22% survive beyond 1 year

renal/urinary system
• bilateral polycystic kidney disease with a progressive increase in the number and size of cysts in the kidney cortex, with slower progression than in kat-2J homozygotes (J:37799)
• cysts seem to be dilated proximal tubules and Bowman spaces (J:37799)

nervous system
• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
• at 7 months of age the choroid plexus has multiple large cysts present in the interstitium
• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
• most of the olfactory glomerular and external granular layers are absent, and in places are replaced by lacy vacuolated tissue
• olfactory lobes are approximately half normal size

growth/size/body
• bilateral polycystic kidney disease with a progressive increase in the number and size of cysts in the kidney cortex, with slower progression than in kat-2J homozygotes (J:37799)
• cysts seem to be dilated proximal tubules and Bowman spaces (J:37799)

craniofacial
• foreshortened face, particularly the snout

hematopoietic system
• hematocrit is slightly reduced in many young homozygotes and falls progressively after 200 days of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 J:37799




Genotype
MGI:3831295
hm3
Allelic
Composition
Nek1kat/Nek1kat
Genetic
Background
involves: C3HeB/FeJLe * RBF/Dn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation (1 available); any Nek1 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: on this mixed genetic background homozygotes survive to adulthood, but still have a shortened lifespan

reproductive system
• homozygous females on this mixed background only breed occasionally

growth/size/body




Genotype
MGI:3831294
hm4
Allelic
Composition
Nek1kat/Nek1kat
Genetic
Background
involves: RBF/Dn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation (1 available); any Nek1 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: on the RBF/Dn background, but not the C3HeB/FeJLe x RBF/Dn mixed background, there is a biphasic death pattern wherein approximately half the homozygotes die before weaning and the remainder die by 1 year of age

craniofacial

growth/size/body
• all homozygotes are runted with shortened bodies

renal/urinary system

skeleton

integument





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory