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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh5tm1Rak
targeted mutation 1, Raju Kucherlapati
MGI:1858057
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh5tm1Rak/Msh5tm1Rak involves: 129/Sv * C57BL/6J * SJL MGI:2183396
cx2
 		Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak 		involves: 129/Sv * C57BL/6 * SJL MGI:2663948


Genotype
MGI:2183396
hm1
Allelic
Composition		 Msh5tm1Rak/Msh5tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh5tm1Rak mutation (1 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ovary cyst ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
ovary degeneration ( J:51921 )
• normal in size at birth, but degenerate progressively to become rudimentary by adulthood
small testis ( J:51921 )
• 70% reduction in size

reproductive system
decreased oocyte number ( J:51921 )
• oocyte numbers declined steadily with degeneration of ovaries
abnormal male meiosis ( J:51921 , J:62204 )
• abnormal chromosomal pairing (J:51921)
(J:62204)
ovary cyst ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
ovary degeneration ( J:51921 )
• normal in size at birth, but degenerate progressively to become rudimentary by adulthood
small testis ( J:51921 )
• 70% reduction in size

growth/size/body
ovary cyst ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
abnormal ovarian bursa morphology ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts

cellular
decreased oocyte number ( J:51921 )
• oocyte numbers declined steadily with degeneration of ovaries
abnormal male meiosis ( J:51921 , J:62204 )
• abnormal chromosomal pairing (J:51921)
(J:62204)




Genotype
MGI:2663948
cx2
Allelic
Composition		 Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (40 available)
Msh5tm1Rak mutation (1 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing

cellular
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory