Phenotypes associated with this allele

• Allele Symbol: Myo5a^d-l20J
• Allele Name: dilute lethal 20 Jackson
• Allele ID: MGI:1858077
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^d-l20J/Myo5a^d-l20J	involves: C57BL/6J	MGI:3785374
hm2	Myo5a^d-l20J/Myo5a^d-l20J	involves: C57BL/6J * DBA/2J	MGI:3713775
cx3	Mreg^dsu/Mreg^dsu Myo5a^d-l20J/Myo5a^d-l20J	involves: C57BL/6J	MGI:3768126

Genotype
MGI:3785374

hm1

• Allelic Composition: Myo5a^d-l20J/Myo5a^d-l20J
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:111253 )

N • cytotoxicity of cytotoxic T cells and NK cells is normal

Genotype
MGI:3713775

hm2

• Allelic Composition: Myo5a^d-l20J/Myo5a^d-l20J
• Genetic Background: involves: C57BL/6J * DBA/2J

mortality/aging

postnatal lethality ( J:20299 )

• death occurs between 18-21 days postpartum

pigmentation

abnormal coat/hair pigmentation ( J:20299 )

diluted coat color ( J:20299 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:20299 )

abnormal involuntary movement ( J:20299 )

opisthotonus ( J:20299 )

• convulsions lead to death by 3 weeks of age

muscle

opisthotonus ( J:20299 )

• convulsions lead to death by 3 weeks of age

integument

abnormal coat/hair pigmentation ( J:20299 )

diluted coat color ( J:20299 )

Genotype
MGI:3768126

cx3

• Allelic Composition: Mreg^dsu/Mreg^dsu; Myo5a^d-l20J/Myo5a^d-l20J
• Genetic Background: involves: C57BL/6J

pigmentation

pigmentation phenotype ( J:20299 )

N • mice display a normal coat color unlike the diluted coat color normally observed in Myo5a^d-120J mice

behavior/neurological

opisthotonus ( J:20299 )

• neurological defects are not rescued

muscle

opisthotonus ( J:20299 )

• neurological defects are not rescued