About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkbiatm1Bal
targeted mutation 1, David Baltimore
MGI:1858084
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkbiatm1Bal/Nfkbiatm1Bal involves: 129S4/SvJae * C57BL/6J MGI:3034093
cx2
 		Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:3053046
cx3
 		Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkbiatm1Bal/Nfkbiatm1Bal 		involves: 129S4/SvJae * C57BL/6J MGI:3034094


Genotype
MGI:3034093
hm1
Allelic
Composition		 Nfkbiatm1Bal/Nfkbiatm1Bal
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:30058 )
• death occurred around the 1st week of age

growth/size/body
decreased body size ( J:30058 )
• although of normal size at birth, homozygotes became noticeably smaller than normal by 3-4 days of age
• by 7 days of age homozygotes were severely runted (1/3 normal weight)

hematopoietic system
abnormal granulocyte differentiation ( J:30058 )
• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
thymus atrophy ( J:30058 )
• atrophy in mice over 6 days of age
increased leukocyte cell number ( J:30058 )
• 3 fold increase in peripheral WBC count - about 95% neutrophils
spleen atrophy ( J:30058 )
• small size by day 2 with a worsening size reduction until death

immune system
abnormal granulocyte differentiation ( J:30058 )
• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
thymus atrophy ( J:30058 )
• atrophy in mice over 6 days of age
increased leukocyte cell number ( J:30058 )
• 3 fold increase in peripheral WBC count - about 95% neutrophils
spleen atrophy ( J:30058 )
• small size by day 2 with a worsening size reduction until death

integument
abnormal epidermis stratum basale morphology ( J:30058 )
• poorly defined basal layer
flaky skin ( J:30058 )
• significant sloughing

cellular
abnormal granulocyte differentiation ( J:30058 )
• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age

endocrine/exocrine glands
thymus atrophy ( J:30058 )
• atrophy in mice over 6 days of age




Genotype
MGI:3053046
cx2
Allelic
Composition		 Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (19 available)
Nfkbietm1Syme mutation (0 available); any Nfkbie mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:88142 )
• double homozygotes are born alive but remain cyanotic and die within 10-30 minutes

hematopoietic system
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive
abnormal B cell differentiation ( J:88142 )
• decreased numbers of B cell precursors
decreased immature B cell number ( J:88142 )
• very low numbers of immature B cells
abnormal T cell differentiation ( J:88142 )
• development from the double positive stage to the single positive stage is reduced
decreased pre-B cell number ( J:88142 )
• clear reduction of B220+CD43- cells

immune system
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive
abnormal B cell differentiation ( J:88142 )
• decreased numbers of B cell precursors
decreased immature B cell number ( J:88142 )
• very low numbers of immature B cells
abnormal T cell differentiation ( J:88142 )
• development from the double positive stage to the single positive stage is reduced
decreased pre-B cell number ( J:88142 )
• clear reduction of B220+CD43- cells

cellular
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive




Genotype
MGI:3034094
cx3
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkbiatm1Bal/Nfkbiatm1Bal
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:30058 )
• survival prolonged until 2-4 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory