Analysis Tools
growth/size/body
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• the heart to body weight ratio is increased by 20% compared to non-transgenic controls
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• approximate 2.5-fold increase in heart weight, suggesting eccentric cardiac hypertrophy in the late stages of cardiomyopathy
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• myocytes located in the right ventricle have a 62% higher cross-section than found in non-transgenic controls
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mortality/aging
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• average age of death is 8.6 +/- 0.7 months
• males survive longer than females, dying on average at 12.4 months compared to 7 months for females
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cardiovascular system
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• systolic and diastolic blood pressure is normal in these mice
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• heart muscle contains elevated levels of diacylglycerol resulting from enhanced signaling by the alpha 1 adrenergic receptor through the Gq-phospholipase C-protein kinase C signaling pathway
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• left ventricular walls exhibit myofibrillar disarray
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• distortion of both ventricles
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• the heart to body weight ratio is increased by 20% compared to non-transgenic controls
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• approximate 2.5-fold increase in heart weight, suggesting eccentric cardiac hypertrophy in the late stages of cardiomyopathy
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• myocytes located in the right ventricle have a 62% higher cross-section than found in non-transgenic controls
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• left ventricular end-systolic area and left ventricular end-diastolic area are higher at 6 and 9 months of age but not at 3 months, indicating progressive left ventricle enlargement with age
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• all 4 cardiac chambers are enlarged
• however, posterior and septum wall thickness are largely unchanged
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• mice exhibit late-onset dilated cardiomyopathy
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• fractional area change is decreased between 3 and 9 months of age by about 20%, indicating loss in left ventricular systolic function
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• left ventricular end-systolic area and left ventricular end-diastolic area are higher at 6 and 9 months of age but not at 3 months, indicating progressive left ventricle enlargement with age
• left ventricular end-systolic area is increased over 80% from 3 to 9 months of age
• fractional area change is decreased between 3 and 9 months of age by about 20%
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• mice present with signs of heart failure, including fatigue and dyspnea, followed by generalized edema and death
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homeostasis/metabolism
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• frequent presence of right atrial thrombus
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• seen before mice die
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muscle
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• heart muscle contains elevated levels of diacylglycerol resulting from enhanced signaling by the alpha 1 adrenergic receptor through the Gq-phospholipase C-protein kinase C signaling pathway
|
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• left ventricular walls exhibit myofibrillar disarray
|
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• myocytes located in the right ventricle have a 62% higher cross-section than found in non-transgenic controls
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• mice exhibit late-onset dilated cardiomyopathy
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• fractional area change is decreased between 3 and 9 months of age by about 20%, indicating loss in left ventricular systolic function
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respiratory system
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• seen before mice die
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:134704 | |
