Phenotypes associated with this allele

• Allele Symbol: Apc^tm1Rfo
• Allele Name: targeted mutation 1, Riccardo Fodde
• Allele ID: MGI:1858101
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apc^tm1Rfo/Apc^tm1Rfo	B6.129P2-Apc^tm1Rfo	MGI:3834191
hm2	Apc^tm1Rfo/Apc^tm1Rfo	involves: 129P2/OlaHsd	MGI:3695565
hm3	Apc^tm1Rfo/Apc^tm1Rfo	involves: 129P2/OlaHsd * C57BL/6J	MGI:2175910

Genotype
MGI:3834191

hm1

• Allelic Composition: Apc^tm1Rfo/Apc^tm1Rfo
• Genetic Background: B6.129P2-Apc^tm1Rfo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:55416 )

• fewer than the expected numbers of homozygotes are observed at weaning on the congenic C57BL/6J background, however no postnatal lethality is seen on a mixed 129P2/OlaHsd and C57BL/6J background

Genotype
MGI:3695565

hm2

• Allelic Composition: Apc^tm1Rfo/Apc^tm1Rfo
• Genetic Background: involves: 129P2/OlaHsd

cellular

cellular phenotype ( J:116121 )

N • no obvious microtubule abnormalities in MEFs in a wound healing assay

Genotype
MGI:2175910

hm3

• Allelic Composition: Apc^tm1Rfo/Apc^tm1Rfo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

mortality/aging ( J:55416 )

N • Background Sensitivity: unlike on a congenic C57BL/6J backround where mutants exhibit postnatal lethality, the expected numbers of homozygotes are observed on a mixed 129P2/OlaHsd and C57BL/6J background

endocrine/exocrine glands

absent male preputial gland ( J:55416 )

♂

growth/size/body

skin cyst ( J:55416 )

• always in proximity of the nipple, most males develop 1-3 cutaneous cysts ranging in size from 1-3 mm

• cysts are hybrid infundibular/matrical cysts lined by orthokeratinizing sqamous epithelium and stretches of matrix cells

decreased body size ( J:55416 )

• due to growth retardation

postnatal growth retardation ( J:55416 )

• 20% growth retardation is apparent by 10 days of age

reproductive system

absent male preputial gland ( J:55416 )

♂

renal/urinary system

absent male preputial gland ( J:55416 )

♂

neoplasm

neoplasm ( J:55416 )

N • mutants are tumor-free unlike most other Apc mutants

integument

absent male preputial gland ( J:55416 )

♂

skin cyst ( J:55416 )

• always in proximity of the nipple, most males develop 1-3 cutaneous cysts ranging in size from 1-3 mm

• cysts are hybrid infundibular/matrical cysts lined by orthokeratinizing sqamous epithelium and stretches of matrix cells