Phenotypes associated with this allele

• Allele Symbol: Gnb5^flr
• Allele Name: flailer
• Allele ID: MGI:1858521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gnb5^flr/Gnb5^flr Myo5a^flr/Myo5a^flr	involves: C57BL/6J * C57BL/10J * CBA/Ca	MGI:3790803

Genotype
MGI:3790803

cx1

• Allelic Composition: Gnb5^flr/Gnb5^flr; Myo5a^flr/Myo5a^flr
• Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:42513 )

• 50% of animals survive only 3 weeks; lethality may be partially background-sensitive

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:42513 , J:61324 )

• frequent falls exhibited by 50% of mice (J:42513)

• by 14 days of age, mice exhibit frequent falling behavior (J:61324)

impaired righting response ( J:42513 , J:61324 )

• legs flail during attempts to right themselves in 50% of animals (J:42513)

• by 14 days of age, mice display convulsive limb movements during attempts to right themselves (J:61324)

opisthotonus ( J:61324 )

• can be stimulated by handling between 2 and 4 weeks of age

ataxia ( J:42513 , J:61324 )

• 50% of homozygotes are severely ataxic (J:42513)

• other 50% show transient ataxia at 3 weeks of age (J:42513)

• adults display mild ataxia (J:61324)

impaired balance ( J:61324 )

• adults cannot maintain balance on a narrow beam

impaired coordination ( J:61324 )

• mice fall off rotating rod within 0.5-1 minute; coordination improves with age

convulsive seizures ( J:61324 )

• increase in frequency between 2 and 4 weeks of age

nervous system

convulsive seizures ( J:61324 )

• increase in frequency between 2 and 4 weeks of age

abnormal cerebellum morphology ( J:61324 )

• localization of smooth endoplasmic reticulum (SER) vesicles is abnormal in cerebellum of 20-day old mice

abnormal Purkinje cell dendrite morphology ( J:61324 )

• Times New Roman

muscle

opisthotonus ( J:61324 )

• can be stimulated by handling between 2 and 4 weeks of age

pigmentation

pigmentation phenotype ( J:61324 )

N • mutants have normal pigment indicating C-terminus exons of Myo5a are not involved in the dilute coat color change associated with other Myo5a mutations