All Phenotypes Trim28<tm1.2Ipc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trim28^tm1.2Ipc
targeted mutation 1.2, Pierre Chambon
MGI:1859550

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim28^tm1.2Ipc/Trim28^tm1.2Ipc	involves: 129S2/SvPas * C57BL/6	MGI:2170897
ht2	Trim28^chatwo/Trim28^tm1.2Ipc	involves: 129S2/SvPas * C57BL/6J	MGI:5620615
cn3	Trim28^tm1.1Ipc/Trim28^tm1.2Ipc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5620619

Allelic Composition	Trim28^tm1.2Ipc/Trim28^tm1.2Ipc
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:62628 )

• die at E6.5-E8.5

embryo

abnormal endoderm development ( J:62628 )

• abnormal endoderm differentiation; reduced cell number

absent mesoderm ( J:62628 )

• failure of mesoderm formation

abnormal extraembryonic endoderm formation ( J:62628 )

• altered morphology

Allelic Composition	Trim28^chatwo/Trim28^tm1.2Ipc
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim28^chatwo mutation (0 available); any Trim28 mutation (36 available)
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:178936 )

• some embryos arrest at E7.5 while others survive until E8.5

embryo

embryonic growth arrest ( J:178936 )

• some embryos arrest at E7.5 while others survive until E8.5

Allelic Composition	Trim28^tm1.1Ipc/Trim28^tm1.2Ipc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (36 available)
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:178936 )

N	• embryos no normal yolk sac protrusions or trophoblast malformations

abnormal vitelline vasculature morphology ( J:178936 )

short rostral-caudal axis ( J:178936 )

embryonic growth arrest ( J:178936 )

• at E8.5

abnormal lateral plate mesoderm morphology ( J:178936 )

• shorter and wider than in control mice

wavy neural tube ( J:178936 )

nervous system

wavy neural tube ( J:178936 )

digestive/alimentary system

abnormal digestive system development ( J:178936 )

• failure of gut closure

cardiovascular system

abnormal vitelline vasculature morphology ( J:178936 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24