Phenotypes associated with this allele

• Allele Symbol: Tal1^Hpt
• Allele Name: hair patches
• Allele ID: MGI:1859843
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tal1^Hpt/Tal1^Hpt	(C57BL/6J x C3FeLe.B6-a/a)F1	MGI:3608700
hm2	Tal1^Hpt/Tal1^Hpt	HPT/Le	MGI:3608708
ht3	Tal1^Hpt/Tal1^+	(C57BL/6J x C3FeLe.B6-a/a)F1	MGI:3608691
ht4	Tal1^Hpt/Tal1^+	HPT/Le	MGI:3608965

Genotype
MGI:3608700

hm1

• Allelic Composition: Tal1^Hpt/Tal1^Hpt
• Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal skin pigmentation ( J:13897 )

integument

abnormal coat appearance ( J:13897 )

• coat appearance of a homozygote can be discerned from a heterozygote only by breeding tests

focal hair loss ( J:13897 )

• the permanent coat may be normal with a few bare patches

sparse hair ( J:13897 )

• some homozygotes have a sparse permanent coat with extensive bare patches

abnormal hair follicle development ( J:13897 )

abnormal skin pigmentation ( J:13897 )

Genotype
MGI:3608708

hm2

• Allelic Composition: Tal1^Hpt/Tal1^Hpt
• Genetic Background: HPT/Le

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:1780 )

• die by 6 to 8 days of gestation

embryo

abnormal ectoderm development ( J:1780 )

• death is associated with abnormalities of ectodermal derivatives

Genotype
MGI:3608691

ht3

• Allelic Composition: Tal1^Hpt/Tal1⁺
• Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

pigmentation

abnormal skin pigmentation ( J:13897 )

• the skin is littered with heavily pigmented debris

integument

abnormal coat appearance ( J:13897 )

focal hair loss ( J:13897 )

• permanent coat of some may be normal but have a few bare patches

sparse hair ( J:13897 )

• the permanent coat of some heterozygotes is sparse with extensive bare patches

abnormal hair follicle development ( J:13897 )

abnormal skin pigmentation ( J:13897 )

• the skin is littered with heavily pigmented debris

Genotype
MGI:3608965

ht4

• Allelic Composition: Tal1^Hpt/Tal1⁺
• Genetic Background: HPT/Le

renal/urinary system

abnormal kidney morphology ( J:1780 )

• model for mechanisms of progressive noninflammatory renal disease

abnormal podocyte foot process morphology ( J:1780 )

• disorganization, swelling, and fusion of the foot processes

fused podocyte foot processes ( J:1780 )

abnormal renal glomerulus morphology ( J:1780 )

glomerulosclerosis ( J:1780 )

• condition is progressive and by 6 months of age most glomeruli show advanced sclerosis

kidney failure ( J:1780 )

• results from progressive glomerulosclerosis

cardiovascular system

enlarged heart ( J:1780 )

heart left ventricle hypertrophy ( J:1780 )

hypertension ( J:1780 )

• increased systolic pressure by 3 months of age

pigmentation

abnormal skin pigmentation ( J:1780 )

• mosaicism for pigmented and unpigmented areas is observed a few days after birth

hematopoietic system

abnormal erythropoiesis ( J:1780 )

anemia ( J:1780 )

• occurs by 40 weeks of age

• assumed secondary to renal failure

decreased leukocyte cell number ( J:1780 )

• before one year of age counts are normal

• at 68 weeks of age the leukocyte count is significanlty decreased with a slight decrease in lymphocytes and increase in neutrophils

growth/size/body

enlarged heart ( J:1780 )

heart left ventricle hypertrophy ( J:1780 )

decreased body size ( J:1780 )

• mutants at all ages are smaller than age and sex-matched controls

immune system

decreased leukocyte cell number ( J:1780 )

• before one year of age counts are normal

• at 68 weeks of age the leukocyte count is significanlty decreased with a slight decrease in lymphocytes and increase in neutrophils

integument

abnormal hair growth ( J:1780 )

• patchy absence of hair throughout life

• pigmented and unpigmented areas observed soon after birth correspond to future areas of abnormal and normal hair growth respectively

alopecia ( J:1780 )

abnormal hair follicle development ( J:1780 )

• follicles may not produce hairs or hairs may not erupt

• keratin plugs follicles

• abnormal follicles are larger than normal

decreased hair follicle number ( J:1780 )

• reduced numbers of normal follicles can be detected as early as E14

abnormal skin pigmentation ( J:1780 )

• mosaicism for pigmented and unpigmented areas is observed a few days after birth

muscle

heart left ventricle hypertrophy ( J:1780 )