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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vpreb1atm1Ilm
targeted mutation 1, Inga-Lill Martensson
MGI:1859923
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm B6.129P2-Vpreb1atm1Ilm MGI:3843023
hm2
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm involves: 129P2/OlaHsd * C57BL/6 MGI:2653710
cx3
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1btm1Ilm 		B6.129P2-Vpreb1atm1Ilm Vpreb1btm1Ilm MGI:3843017
cx4
 		Vpreb1atm1Ilm/Vpreb1a+
Vpreb1btm1Ilm/Vpreb1btm3Ilm 		involves: 129P2/OlaHsd * C57BL/6 MGI:3843020
cx5
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3843022


Genotype
MGI:3843023
hm1
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Genetic
Background		 B6.129P2-Vpreb1atm1Ilm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 35%
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are enriched about 1.6 fold

hematopoietic system
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 35%
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are enriched about 1.6 fold




Genotype
MGI:2653710
hm2
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:53512 )
N
• allelic exclusion of IgH occurs normally
• good antibody response to T cell dependent antigens
arrested B cell differentiation ( J:53512 )
• accumulation of cells at the pre-BI stage, indicating a partial block at the transition from pre-BI to pre-BII cells (into the pre-BCR stage)
abnormal pre-B cell morphology ( J:53512 )
• percentage of pre-BI cells is increased and the percentage of pre-BII and immature B cells is slightly decreased

hematopoietic system
arrested B cell differentiation ( J:53512 )
• accumulation of cells at the pre-BI stage, indicating a partial block at the transition from pre-BI to pre-BII cells (into the pre-BCR stage)
abnormal pre-B cell morphology ( J:53512 )
• percentage of pre-BI cells is increased and the percentage of pre-BII and immature B cells is slightly decreased




Genotype
MGI:3843017
cx3
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1btm1Ilm
Genetic
Background		 B6.129P2-Vpreb1atm1Ilm Vpreb1btm1Ilm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Ilm mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:67609 )
N
• heavy chain allelic exclusion still occurs normally
• IgM levels are normal
abnormal B cell differentiation ( J:67609 )
• B220+ cells decreased to about half of control levels in bone marrow
• CD19+ cells reduced in numbers in bone marrow
• B220+ CD19- cell numbers are normal in bone marrow
abnormal immature B cell morphology ( J:67609 )
• number of IgM+ cells reduced 25 fold in young and 10 fold in old mice
• transformation from pre-BII to immature B cells is normal
decreased mature B cell number ( J:67609 )
• IgM+ cells reduced 25 fold in young and 10 fold in older mice
• similar reduction in IgM+ IgD+ mature B cells
decreased B-1a cell number ( J:67609 )
• numbers are reduced in 10-12 day old mice
• numbers return to normal by 9-13 weeks of age
• only B cell lineage to recover to normal numbers
decreased pre-B cell number ( J:67609 )
• pre-BII cells reduced about 40 fold in young mice (B220+ CD25+)
• pre-BII cells reduced about 10 fold in older mice
• ratio of large to small pre-BII cells is about 1:1 or 1:1.5 compared to 1:4 in controls
• 5 fold reduction in large and 15 fold reduction in small pre-BII cells
• defective proliferative expansion of pre-BII cells
• decreased large pre-BII cells with further reduction of small pre-BII cells
increased pre-B cell number ( J:67609 )
• pre-BI cell numbers are increased about 2 fold in bone marrow (B220+, c-Kit+)
• CD19+, c-Kit+ cells also increased about 2 fold
abnormal splenic cell ratio ( J:67609 )
• total nucleated cells reduced to about 70% in young and 45% in older mice
• B cell numbers increase with age, mostly as mature cells
decreased IgG level ( J:67609 )
• slightly decrease IgG antibody response

hematopoietic system
abnormal B cell differentiation ( J:67609 )
• B220+ cells decreased to about half of control levels in bone marrow
• CD19+ cells reduced in numbers in bone marrow
• B220+ CD19- cell numbers are normal in bone marrow
abnormal immature B cell morphology ( J:67609 )
• number of IgM+ cells reduced 25 fold in young and 10 fold in old mice
• transformation from pre-BII to immature B cells is normal
decreased bone marrow cell number ( J:67609 )
• slight decrease in nucleated bone marrow cells at 10 days of age
• decreased number of nucleated bone marrow cells becomes more prominent after 50 days of age
decreased mature B cell number ( J:67609 )
• IgM+ cells reduced 25 fold in young and 10 fold in older mice
• similar reduction in IgM+ IgD+ mature B cells
decreased B-1a cell number ( J:67609 )
• numbers are reduced in 10-12 day old mice
• numbers return to normal by 9-13 weeks of age
• only B cell lineage to recover to normal numbers
decreased pre-B cell number ( J:67609 )
• pre-BII cells reduced about 40 fold in young mice (B220+ CD25+)
• pre-BII cells reduced about 10 fold in older mice
• ratio of large to small pre-BII cells is about 1:1 or 1:1.5 compared to 1:4 in controls
• 5 fold reduction in large and 15 fold reduction in small pre-BII cells
• defective proliferative expansion of pre-BII cells
• decreased large pre-BII cells with further reduction of small pre-BII cells
increased pre-B cell number ( J:67609 )
• pre-BI cell numbers are increased about 2 fold in bone marrow (B220+, c-Kit+)
• CD19+, c-Kit+ cells also increased about 2 fold
abnormal splenic cell ratio ( J:67609 )
• total nucleated cells reduced to about 70% in young and 45% in older mice
• B cell numbers increase with age, mostly as mature cells
decreased IgG level ( J:67609 )
• slightly decrease IgG antibody response




Genotype
MGI:3843020
cx4
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1a+
Vpreb1btm1Ilm/Vpreb1btm3Ilm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Ilm mutation (0 available); any Vpreb1b mutation (8 available)
Vpreb1btm3Ilm mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:104211 )
N
• development of B cells in bone marrow is normal




Genotype
MGI:3843022
cx5
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Ilm mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:104211 )
• B220+ IgM+ cells reduced about 75%
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 75%
• ratio of large to small pre-BII cells is normal
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are increased about 2 fold

hematopoietic system
decreased mature B cell number ( J:104211 )
• B220+ IgM+ cells reduced about 75%
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 75%
• ratio of large to small pre-BII cells is normal
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are increased about 2 fold




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Send questions and comments to User Support. 		last database update
08/27/2024
MGI 6.24 		The Jackson Laboratory