Phenotypes associated with this allele

• Allele Symbol: t^btm
• Allele Name: t, brachyury interacting tail length modifier
• Allele ID: MGI:1860107
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	t^btm/t^btm	MOL-NIS	MGI:4819840
cx2	T/t^btm	involves: C57BL/6 * MOL-NIS	MGI:4457262
cx3	T/t^btm	MOL-NIS	MGI:4819839

Genotype
MGI:4819840

hm1

• Allelic Composition: t^btm/t^btm
• Genetic Background: MOL-NIS

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

short tail ( J:14919 )

• all mice with this genotype have short tails and fully viable and fertile

Genotype
MGI:4457262

cx2

• Allelic Composition: T/t^btm
• Genetic Background: involves: C57BL/6 * MOL-NIS

embryo

abnormal rostral-caudal body axis extension ( J:21054 )

• attenuated development of the posterior part of the body

abnormal neural tube morphology ( J:21054 )

• generally distorted, duplicated or fused with the mesenchyme

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

abnormal notochord morphology ( J:21054 )

• E11-12 embryos show abnormalities in the medio-dorsal area

notochord degeneration ( J:21054 )

• seen in E11-12 embryos

split notochord ( J:21054 )

• seen in E11-12 embryos

abnormal tail bud morphology ( J:21054 )

• at E10 a constriction occurs as the tail develops

nervous system

abnormal neural tube morphology ( J:21054 )

• generally distorted, duplicated or fused with the mesenchyme

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

abnormal spinal cord morphology ( J:21054 )

• posterior to the lumbosacral level the cord is severely distorted or duplicated and devoid of vertebrae

limbs/digits/tail

absent caudal vertebrae ( J:21054 )

abnormal tail development ( J:21054 )

abnormal tail bud morphology ( J:21054 )

• at E10 a constriction occurs as the tail develops

absent tail ( J:21054 )

• mice with this genotype lack a tail at birth and have blood listers or red scars on the dorsal skin at the middle of the lumbosacral region

skeleton

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

absent caudal vertebrae ( J:21054 )

abnormal thoracic vertebrae morphology ( J:21054 )

• rib fusions, lack of vertebral bodies and arches

abnormal lumbar vertebrae morphology ( J:21054 )

• rib fusions, lack of vertebral bodies and arches

absent sacral vertebrae ( J:21054 )

absent vertebral arch ( J:21054 )

• an abnormality of thoracic and lumbar vertebrae

absent vertebral body ( J:21054 )

• an abnormality of thoracic and lumbar vertebrae

absent vertebrae ( J:21054 )

Genotype
MGI:4819839

cx3

• Allelic Composition: T/t^btm
• Genetic Background: MOL-NIS

mortality/aging

decreased survivor rate ( J:14919 )

• all mice are dead by 60 days of age; the few longest-lived have hind-limb paralysis

perinatal lethality, incomplete penetrance ( J:14919 )

• most die shortly after birth and have a blood blister in the lumbosacral area and hind-limb paralysis

limbs/digits/tail

absent tail ( J:14919 )

• all mice of this genotype are tailless

reproductive system

reproductive system phenotype ( J:14919 )

N • mice are fertile and there is no evidence of transmission ratio distortion