Analysis Tools
mortality/aging
|
• average life span is 166+/-49 days
|
|
• some pups die before weaning
|
cardiovascular system
|
• myocardial arteriosclerosis
|
digestive/alimentary system
|
• retained eosinophilic granules in many acinar cells
|
|
• gland contains very few mucous secreting acini
• gland structure is predominantly serous rather than mucous
|
endocrine/exocrine glands
|
• retained eosinophilic granules in many acinar cells
|
|
• gland contains very few mucous secreting acini
• gland structure is predominantly serous rather than mucous
|
hematopoietic system
small spleen
(
J:101669
)
|
• splenic lymphocytes are reduced in number
|
homeostasis/metabolism
immune system
small spleen
(
J:101669
)
|
• splenic lymphocytes are reduced in number
|
|
• chronic active pneumonia is observed in many mice
• lungs exhibit infiltrating macrophages and lymphocytes
• bronchial hypersecretion
|
liver/biliary system
behavior/neurological
|
• hind limbs drag as mice age
|
renal/urinary system
|
• tubular nephropathy
|
|
• global diffuse glomerulosclerosis is detectable as early as 5 weeks of age
• glomeruli exhibit decreased cellularity and irregular thickening of the capillary basement membrane and mesangial matrix
• irregular dense granular deposits are observed in and on both sides of basement membrane and mesangium
|
reproductive system
 |
• numerous giant cells observed in epididymis
|
|
• poor breeders
|
respiratory system
|
• chronic active pneumonia is observed in many mice
• lungs exhibit infiltrating macrophages and lymphocytes
• bronchial hypersecretion
|
|
• hypertrophy of bronchiolar lining cells
|
