All Phenotypes Thrb<tm1Olc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm1Olc/Thrb^tm1Olc	involves: 129	MGI:4358576
cx2	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thrb^tm1Olc/Thrb^tm1Olc	B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc	MGI:4358582
cx3	Thra^tm1Jas/Thra^tm1Jas Thrb^tm1Olc/Thrb^tm1Olc	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:4358577
cx4	Thra^tm1Jas/Thra⁺ Thrb^tm1Olc/Thrb^tm1Olc	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:4358578

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

small fontanelles ( J:120899 )

• 64% reduction in skull fontanelle area at P1 due to advanced intramembranous ossification

abnormal osteoclast physiology ( J:120899 )

• at P154, the resorption surface is increased 22% in cortical bone, and 10% in trabecular bone compared to in wild-type mice

short tibia ( J:120899 )

• up to 5% shorter between P21 and P56 with persistent short tibias in adults

abnormal long bone epiphyseal plate morphology ( J:120899 )

• the reserve, proliferative, and hypertrophic zones are narrower than in wild-type mice

• however, by P56 the epiphyseal plate is normal

• the long bone epiphyseal plate is narrow with advanced secondary centers of ossification at P21

decreased long bone epiphyseal plate size ( J:120899 )

• narrow

abnormal bone structure ( J:120899 )

• at P21, calcified bone is increased compared to in wild-type mice

increased osteoclast cell number ( J:120899 )

• 20% at P154

decreased compact bone thickness ( J:120899 )

• after P56

increased compact bone thickness ( J:120899 )

• 11% at P21

abnormal trabecular bone morphology ( J:120899 )

• in juvenile mice, the bone volume fraction and trabecular thickness are increased compared to in wild-type mice

• at P154, trabecular bone mass is decreased with reduced connectivity and rod-like morphology compared to in wild-type mice

decreased trabecular bone thickness ( J:120899 )

• at P154

osteoporosis ( J:120899 )

• in adult mice

abnormal bone mineralization ( J:120899 )

• bone mineralization is reduced compared to in wild-type mice

premature endochondral bone ossification ( J:120899 )

• at E17.5, P1, and P21 but not P56

abnormal chondrocyte physiology ( J:114970 )

• T3-treated chondrocytes fail to exhibit a decreased in proliferation and an increase in alkaline phosphatase activity unlike similarly treated wild-type cells

• however, chondrocytes retain their ability to differentiate following treatment with BMP2

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:120899 )

• at P21

increased circulating thyroid-stimulating hormone level ( J:52829 , J:120899 , J:126521 )

• 10-fold (J:120899)

• mice exhibit increased serum TSH levels compared with wild-type mice (J:126521)

• after a low-iodine diet and propylthiouracil, mice exhibit increased TSH serum levels compared to in similarly treated wild-type mice (J:126521)

increased circulating thyroxine level ( J:52829 , J:68577 , J:120899 , J:126521 )

• mice develop hyperthyroidism (J:68577)

• however, treatment with 5-propyl-2-thiouracil (PTU) and a low-iodine diet restores euthyroid state (J:68577)

increased circulating triiodothyronine level ( J:52829 , J:126521 )

abnormal response/metabolism to endogenous compounds ( J:120899 , J:126521 )

• mice exhibit resistance to thyroid hormone unlike wild-type mice (J:120899)

• at P154, mice fail to exhibit trabecular thinning when treated with T4 unlike wild-type mice (J:120899)

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit some resistance to thyroid hormone compared with wild-type mice (J:126521)

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:52829 )

• mice exhibit an increase in follicle number and size with different size, content, aspects of colloid, and development of vascularization compared with wild-type mice

thyroid gland hyperplasia ( J:52829 )

• diffuse

increased activity of thyroid gland ( J:120899 )

• mice exhibit skeletal thyrotoxicosis (hyperthyrodism)

cardiovascular system

cardiovascular system phenotype ( J:68577 )

N	• left ventricular papillary muscle contraction is normal

increased heart rate ( J:68577 )

• mice exhibit tachycardia

• however, treatment with 5-propyl-2-thiouracil (PTU) and a low-iodine diet restores normal heart rate

digestive/alimentary system

digestive/alimentary phenotype ( J:52829 )

N	• mice exhibit normal intestinal morphology

craniofacial

small fontanelles ( J:120899 )

• 64% reduction in skull fontanelle area at P1 due to advanced intramembranous ossification

growth/size/body

decreased body weight ( J:120899 )

• at P56, P70, P98, and P119

hematopoietic system

increased osteoclast cell number ( J:120899 )

• 20% at P154

abnormal osteoclast physiology ( J:120899 )

• at P154, the resorption surface is increased 22% in cortical bone, and 10% in trabecular bone compared to in wild-type mice

immune system

increased osteoclast cell number ( J:120899 )

• 20% at P154

abnormal osteoclast physiology ( J:120899 )

• at P154, the resorption surface is increased 22% in cortical bone, and 10% in trabecular bone compared to in wild-type mice

limbs/digits/tail

short tibia ( J:120899 )

• up to 5% shorter between P21 and P56 with persistent short tibias in adults

short limbs ( J:120899 )

short tail ( J:120899 )

• after P21

Allelic Composition	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thrb^tm1Olc/Thrb^tm1Olc
Genetic Background	B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa1^tm1Bwo mutation (0 available); any Ncoa1 mutation (169 available)
Thrb^tm1Olc mutation (2 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:126521 )

• mice exhibit increased TSH levels

• after a low-iodine diet and propylthiouracil, TSH serum levels more than wild-type

increased circulating thyroxine level ( J:126521 )

increased circulating triiodothyronine level ( J:126521 )

abnormal response/metabolism to endogenous compounds ( J:126521 )

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit more resistance to thyroid hormone compared with wild-type mice or either single homozygote

Allelic Composition	Thra^tm1Jas/Thra^tm1Jas Thrb^tm1Olc/Thrb^tm1Olc
Genetic Background	involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Jas mutation (0 available); any Thra mutation (39 available)
Thrb^tm1Olc mutation (2 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:52829 )

• at 5 weeks

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:52829 )

• increased in follicle number with different size, content, aspects of colloid, and development of vascularization

• follicles are smaller than normal and exhibit signs of hyperactivity including colloid vacuoles, cuboid epithelium, and hypervascularization

thyroid gland hyperplasia ( J:52829 )

• diffuse

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:52829 )

• 100-fold

increased circulating thyroxine level ( J:52829 )

• 10-fold

increased triiodothyronine level ( J:52829 )

• 10-fold

skeleton

abnormal long bone epiphyseal plate morphology ( J:52829 )

• mice exhibit impaired development of epiphyseal bone centers characterized by hypertrophied cartilage associated with low ossification unlike in wild-type mice

delayed skeletal maturation ( J:52829 )

• bone maturation is delayed compared to in wild-type mice

digestive/alimentary system

delayed intestine development ( J:52829 )

• intestine maturation is delayed compared to in wild-type mice

abnormal small intestine morphology ( J:52829 )

• at 2 weeks, the intestine is shorter and more fragile than in wild-type mice

• as in Thra^tm1Jas homozygotes, proximal jejunum crypt-villus units length is reduced compared to in wild-type mice

• in the distal ileum epithelial cells are flat with few and short villi compared to in wild-type mice or Thra^tm1Jas homozygotes

decreased small intestinal villus size ( J:52829 )

• in the distal ileum and proximal jejunum

growth/size/body

decreased body weight ( J:52829 )

• after 3 weeks

postnatal growth retardation ( J:52829 )

• postnatal growth ceases at 15 days and after 3 weeks mice exhibit a decrease in body weight

Allelic Composition	Thra^tm1Jas/Thra⁺ Thrb^tm1Olc/Thrb^tm1Olc
Genetic Background	involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:52829 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24