All Phenotypes Thrb<tm1Olc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm1Olc/Thrb^tm1Olc	involves: 129	MGI:4358576
cx2	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thrb^tm1Olc/Thrb^tm1Olc	B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc	MGI:4358582
cx3	Thra^tm1Jas/Thra^tm1Jas Thrb^tm1Olc/Thrb^tm1Olc	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:4358577
cx4	Thra^tm1Jas/Thra⁺ Thrb^tm1Olc/Thrb^tm1Olc	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:4358578

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

small fontanelles ( J:120899 )

• 64% reduction in skull fontanelle area at P1 due to advanced intramembranous ossification

abnormal osteoclast physiology ( J:120899 )

• at P154, the resorption surface is increased 22% in cortical bone, and 10% in trabecular bone compared to in wild-type mice

short tibia ( J:120899 )

• up to 5% shorter between P21 and P56 with persistent short tibias in adults

abnormal long bone epiphyseal plate morphology ( J:120899 )

• the long bone epiphyseal plate is narrow with advanced secondary centers of ossification at P21

• however, by P56 the epiphyseal plate is normal

• the reserve, proliferative, and hypertrophic zones are narrower than in wild-type mice

decreased long bone epiphyseal plate size ( J:120899 )

• narrow

abnormal bone structure ( J:120899 )

• at P21, calcified bone is increased compared to in wild-type mice

increased osteoclast cell number ( J:120899 )

• 20% at P154

decreased compact bone thickness ( J:120899 )

• after P56

increased compact bone thickness ( J:120899 )

• 11% at P21

abnormal trabecular bone morphology ( J:120899 )

• in juvenile mice, the bone volume fraction and trabecular thickness are increased compared to in wild-type mice

• at P154, trabecular bone mass is decreased with reduced connectivity and rod-like morphology compared to in wild-type mice

decreased trabecular bone thickness ( J:120899 )

• at P154

osteoporosis ( J:120899 )

• in adult mice

abnormal bone mineralization ( J:120899 )

• bone mineralization is reduced compared to in wild-type mice

premature endochondral bone ossification ( J:120899 )

• at E17.5, P1, and P21 but not P56

abnormal chondrocyte physiology ( J:114970 )

• T3-treated chondrocytes fail to exhibit a decreased in proliferation and an increase in alkaline phosphatase activity unlike similarly treated wild-type cells

• however, chondrocytes retain their ability to differentiate following treatment with BMP2

homeostasis/metabolism

increased circulating thyroxine level ( J:52829 , J:68577 , J:120899 , J:126521 )

• mice develop hyperthyroidism (J:68577)

• however, treatment with 5-propyl-2-thiouracil (PTU) and a low-iodine diet restores euthyroid state (J:68577)

increased circulating triiodothyronine level ( J:52829 , J:126521 )

decreased circulating insulin-like growth factor I level ( J:120899 )

• at P21

increased circulating thyroid-stimulating hormone level ( J:52829 , J:120899 , J:126521 )

• 10-fold (J:120899)

• mice exhibit increased serum TSH levels compared with wild-type mice (J:126521)

• after a low-iodine diet and propylthiouracil, mice exhibit increased TSH serum levels compared to in similarly treated wild-type mice (J:126521)

abnormal response/metabolism to endogenous compounds ( J:120899 , J:126521 )

• mice exhibit resistance to thyroid hormone unlike wild-type mice (J:120899)

• at P154, mice fail to exhibit trabecular thinning when treated with T4 unlike wild-type mice (J:120899)

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit some resistance to thyroid hormone compared with wild-type mice (J:126521)

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:52829 )

• mice exhibit an increase in follicle number and size with different size, content, aspects of colloid, and development of vascularization compared with wild-type mice

thyroid gland hyperplasia ( J:52829 )

• diffuse

increased activity of thyroid gland ( J:120899 )

• mice exhibit skeletal thyrotoxicosis (hyperthyrodism)

cardiovascular system

cardiovascular system phenotype ( J:68577 )

N	• left ventricular papillary muscle contraction is normal

increased heart rate ( J:68577 )

• mice exhibit tachycardia

• however, treatment with 5-propyl-2-thiouracil (PTU) and a low-iodine diet restores normal heart rate

digestive/alimentary system

digestive/alimentary phenotype ( J:52829 )

N	• mice exhibit normal intestinal morphology

craniofacial

small fontanelles ( J:120899 )

• 64% reduction in skull fontanelle area at P1 due to advanced intramembranous ossification

growth/size/body

decreased body weight ( J:120899 )

• at P56, P70, P98, and P119

hematopoietic system

increased osteoclast cell number ( J:120899 )

• 20% at P154

abnormal osteoclast physiology ( J:120899 )

• at P154, the resorption surface is increased 22% in cortical bone, and 10% in trabecular bone compared to in wild-type mice

immune system

increased osteoclast cell number ( J:120899 )

• 20% at P154

abnormal osteoclast physiology ( J:120899 )

• at P154, the resorption surface is increased 22% in cortical bone, and 10% in trabecular bone compared to in wild-type mice

limbs/digits/tail

short tibia ( J:120899 )

• up to 5% shorter between P21 and P56 with persistent short tibias in adults

short limbs ( J:120899 )

short tail ( J:120899 )

• after P21

Allelic Composition	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thrb^tm1Olc/Thrb^tm1Olc
Genetic Background	B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa1^tm1Bwo mutation (0 available); any Ncoa1 mutation (169 available)
Thrb^tm1Olc mutation (2 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating thyroxine level ( J:126521 )

increased circulating triiodothyronine level ( J:126521 )

increased circulating thyroid-stimulating hormone level ( J:126521 )

• mice exhibit increased TSH levels

• after a low-iodine diet and propylthiouracil, TSH serum levels more than wild-type

abnormal response/metabolism to endogenous compounds ( J:126521 )

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit more resistance to thyroid hormone compared with wild-type mice or either single homozygote

Allelic Composition	Thra^tm1Jas/Thra^tm1Jas Thrb^tm1Olc/Thrb^tm1Olc
Genetic Background	involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Jas mutation (0 available); any Thra mutation (40 available)
Thrb^tm1Olc mutation (2 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:52829 )

• at 5 weeks

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:52829 )

• increased in follicle number with different size, content, aspects of colloid, and development of vascularization

• follicles are smaller than normal and exhibit signs of hyperactivity including colloid vacuoles, cuboid epithelium, and hypervascularization

thyroid gland hyperplasia ( J:52829 )

• diffuse

homeostasis/metabolism

increased circulating thyroxine level ( J:52829 )

• 10-fold

increased triiodothyronine level ( J:52829 )

• 10-fold

increased circulating thyroid-stimulating hormone level ( J:52829 )

• 100-fold

skeleton

abnormal long bone epiphyseal plate morphology ( J:52829 )

• mice exhibit impaired development of epiphyseal bone centers characterized by hypertrophied cartilage associated with low ossification unlike in wild-type mice

delayed skeletal maturation ( J:52829 )

• bone maturation is delayed compared to in wild-type mice

digestive/alimentary system

delayed intestine development ( J:52829 )

• intestine maturation is delayed compared to in wild-type mice

abnormal small intestine morphology ( J:52829 )

• at 2 weeks, the intestine is shorter and more fragile than in wild-type mice

• as in Thra^tm1Jas homozygotes, proximal jejunum crypt-villus units length is reduced compared to in wild-type mice

• in the distal ileum epithelial cells are flat with few and short villi compared to in wild-type mice or Thra^tm1Jas homozygotes

decreased small intestinal villus size ( J:52829 )

• in the distal ileum and proximal jejunum

growth/size/body

decreased body weight ( J:52829 )

• after 3 weeks

postnatal growth retardation ( J:52829 )

• postnatal growth ceases at 15 days and after 3 weeks mice exhibit a decrease in body weight

Allelic Composition	Thra^tm1Jas/Thra⁺ Thrb^tm1Olc/Thrb^tm1Olc
Genetic Background	involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:52829 )

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