All Phenotypes Thra<tm1Ven> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm1Ven/Thra^tm1Ven	involves: 129P2/OlaHsd * BALB/c	MGI:3606706
ht2	Thra^tm1Ven/Thra^tm3Ven	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:3606069
cx3	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb^tm1Df	B6.129-Thra^tm1Ven Thrb^tm1Df	MGI:3698827
cx4	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb⁺	B6.129-Thra^tm1Ven Thrb^tm1Df	MGI:3698828
cx5	Thra^tm1Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df	B6.129-Thra^tm1Ven Thrb^tm1Df	MGI:3698829
cx6	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb^tm1Df	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3715649
cx7	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb^tm1Df	involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J	MGI:3698837

Allelic Composition	Thra^tm1Ven/Thra^tm1Ven
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Ven mutation (1 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased activity of thyroid gland ( J:45675 )

• mutant male mice had lower levels of free T4 than control animals

• no significant differences were found between the female mutant homozygous mice and control

• the T3 level were normal in all mice

• the thyroid glands of mutant mice are normal histologically and no goitre has been detected during 18 month observation

cardiovascular system

decreased heart rate ( J:45675 )

• mutant mice have a lower mean heart rate

• daily injection of T3 resulted in an increase in heart rate but failed to reach the same heart rate as the control group

prolonged QT interval ( J:45675 )

• mutant mice have prolonged QRS- and QTend-interval

• the QTend duration is markedly prolonged in mutant mice suggesting slow ventricular repolarization

homeostasis/metabolism

decreased body temperature ( J:45675 )

• 24 h mean body temperature, recorded by the telemetry system, is 0.5 degree C lower in the mutant than the controls

behavior/neurological

behavior/neurological phenotype ( J:103702 )

N	• homozygotes show no significant incidence of audiogenic seizure susceptibility above the 27% incidence noted in background-matched wild-type mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:48666 , J:118178 )

(J:48666)

• at 2-3 months of age, homozygotes exhibit normal auditory-evoked brainstem response (ABR) thresholds for click, 8-, 16-, and 32-kHz frequency stimuli (J:118178)

• in accord with normal ABRs, mutant IHCs show normal developmental expression of the fast-activating potassium current I_K,f at the onset of hearing, indicating normal IHC physiology (J:118178)

abnormal cochlear outer hair cell morphology ( J:111711 )

• despite lack of evidence for a role in hearing, Thra appears to be involved in the final differentiation of cochlear OHCs, as shown by studies of KCNQ4 and prestin protein expression under conditions of goitrogen-induced hypothyroidism

nervous system

abnormal cochlear outer hair cell morphology ( J:111711 )

Allelic Composition	Thra^tm1Ven/Thra^tm3Ven
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Ven mutation (1 available); any Thra mutation (39 available)
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• compound heterozygous mutants exhibited 35% less body weight at 35 days of age compared with simple heterozygous Thra^tm1Ven/Thra⁺ controls

• 70-day-old heterozygous mice weighed only 16% less than simple heterozygous Thra^tm1Ven/Thra⁺ controls

abnormal postnatal growth ( J:100290 )

• delayed eye opening

Allelic Composition	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb^tm1Df
Genetic Background	B6.129-Thra^tm1Ven Thrb^tm1Df

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Ven mutation (1 available); any Thra mutation (39 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal auditory brainstem response ( J:73382 )

• on a congenic C57BL/6J background, adult double homozygotes display significantly exacerbated defects in auditory function relative to single Thrb^tm1Df homozygotes, with no detectable ABR waveform for click stimuli at 100 dB SPL, and only weak, atypical waveforms for high-frequency stimuli (16 and 32 kHz) where initial peaks are either absent or delayed

• Background Sensitivity: on a mixed genetic background of equal parts 129/Sv, 129OlaHsd, BALB/c, and C57BL/6J strains, ABR responses are similar but more variable than those observed on a congenic C57BL/6J background

reproductive system

abnormal sperm motility ( J:117324 )

• postpubertal males show a slight but significant decrease in the swimming velocities of their spermatozoa

• however, testicular histology appears to be complete and fails to show arrested or disorganized tubules; both, the efferent ducts and epididymis appear normal

decreased testis weight ( J:117324 )

• postpubertal males show a significantly decreased testis weight relative to controls

• in contrast, weights of accessory sex glands (seminal vesicles and coagulating glands) are similar to those of wild-type males

female infertility ( J:73382 )

• female double homozygotes are infertile but thrive relatively well

homeostasis/metabolism

abnormal pituitary hormone level ( J:117324 )

• postpubertal males display increased beta-TSH mRNA expression as well as reduced prolactin, growth hormone, luteinizing hormone (beta-LH), follicle-stimulating hormone (beta-FSH), and proopiomelanocortin transcript levels in anterior pituitary

decreased follicle stimulating hormone level ( J:117324 )

decreased growth hormone level ( J:117324 )

decreased luteinizing hormone level ( J:117324 )

decreased prolactin level ( J:117324 )

increased thyroid-stimulating hormone level ( J:117324 )

endocrine/exocrine glands

decreased testis weight ( J:117324 )

• postpubertal males show a significantly decreased testis weight relative to controls

• in contrast, weights of accessory sex glands (seminal vesicles and coagulating glands) are similar to those of wild-type males

growth/size/body

decreased body weight ( J:117324 )

• postpubertal male display a significantly reduced body weight relative to controls

cellular

abnormal sperm motility ( J:117324 )

• postpubertal males show a slight but significant decrease in the swimming velocities of their spermatozoa

• however, testicular histology appears to be complete and fails to show arrested or disorganized tubules; both, the efferent ducts and epididymis appear normal

Allelic Composition	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb⁺
Genetic Background	B6.129-Thra^tm1Ven Thrb^tm1Df

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:73382 )

N	• on a congenic C57BL/6J background, these mutant mice display normal ABR responses to click and pure tone stimuli (8, 16, and 32 kHz)

Allelic Composition	Thra^tm1Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df
Genetic Background	B6.129-Thra^tm1Ven Thrb^tm1Df

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:73382 )

• on a congenic C57BL/6J background, these mutant mice display ABR thresholds that are intermediate between those of single Thrb^tm1Df homozygotes and double homozygotes

Allelic Composition	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb^tm1Df
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small pituitary gland ( J:95391 )

• pituitary size is reduced by 20-30%

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:95391 )

• serum TSH concentration is increased 728.8- to 56.1-fold at 1-2 months of age and 9-12 months of age, respectively

increased circulating thyroxine level ( J:95391 )

• total T4 is increased 14- to 18-fold from the ages of 1-2 and 9-12 months

increased circulating triiodothyronine level ( J:95391 )

• total T3 is increased from 15.9-fold at 1-2 months of age to 26.4-fold at 9-12 months of age

nervous system

small pituitary gland ( J:95391 )

• pituitary size is reduced by 20-30%

neoplasm

neoplasm ( J:95391 )

N	• do not develop focal adenomas as are seen in Thrb^tm1.1Syc homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:73382 )

• double homozygotes are viable but prone to die under anesthesia

hearing/vestibular/ear

delayed inner ear development ( J:73382 )

• double homozygotes exhibit a significant delay in early postnatal development of the organ of Corti

abnormal organ of Corti morphology ( J:73382 )

• at P8, no inner sulcus is formed and the tunnel of Corti between the inner and outer pillar cells has not opened

• at 7-8 weeks, the tunnel of Corti and inner sulcus have opened, but the tunnel of Corti appears somewhat misshapen

abnormal pillar cell morphology ( J:73382 )

• at P8, pillar cells abnormally protrude above the epithelium between IHCs and OHCs

abnormal tectorial membrane morphology ( J:73382 )

• at P8, the tectorial membrane is deformed and remains attached to the underlying epithelium

• the greater epithelial ridge below the tectorial membrane is significantly thicker than normal

abnormal tectorial membrane striated-sheet matrix morphology ( J:73382 )

• ultrastructurally, 6-month-old double homozygotes display a significant disorganization of the striated sheet matrix throughout the tectorial membrane

enlarged tectorial membrane ( J:73382 )

• at P8, the tectorial membrane is enlarged

• at 7-8 weeks, the tectorial membrane remains enlarged in apical and mid-turns of the cochlea but is often retracted in basal turns

decreased endocochlear potential ( J:73382 )

• adult double homozygotes exhibit a reduced endocochlear potential (52.1 13.6 mV) relative to wild-type mice (92.5 13.5 mV) or single Thrb^tm1Df homozygotes (85.2 13.5 mV)

abnormal cochlear inner hair cell physiology ( J:73382 )

• double homozygotes exhibit a similar delay in the induction of the fast-activating potassium current I_K,f relative to single Thrb^tm1Df homozygotes

• at P25, the fast component I_K,f is largely absent in double homozygous mutant IHCs, but eventually rises at later postnatal ages

abnormal cochlear outer hair cell physiology ( J:73382 )

decreased cochlear outer hair cell electromotility ( J:73382 )

• at P8, double homozygotes exhibit a significant impairment of electromechanical transduction in OHCs, as shown by markedly reduced nonlinear capacitance (87 32 fF/pF) relative to wild-type mice (290 47 fF/pF) or single Thrb^tm1Df homozygotes (150 46 fF/pF)

growth/size/body

decreased body size ( J:73382 )

• adult double homozygotes are 30% smaller than wild-type mice

reproductive system

female infertility ( J:73382 )

• female double homozygotes are infertile but thrive relatively well

nervous system

abnormal cochlear inner hair cell physiology ( J:73382 )

• double homozygotes exhibit a similar delay in the induction of the fast-activating potassium current I_K,f relative to single Thrb^tm1Df homozygotes

• at P25, the fast component I_K,f is largely absent in double homozygous mutant IHCs, but eventually rises at later postnatal ages

abnormal cochlear outer hair cell physiology ( J:73382 )

decreased cochlear outer hair cell electromotility ( J:73382 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:73382 )

• double homozygotes are viable but prone to die under anesthesia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13