Phenotypes associated with this allele

• Allele Symbol: Thra^tm1Jas
• Allele Name: targeted mutation 1, Jacques Samarut
• Allele ID: MGI:1860442
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm1Jas/Thra^tm1Jas	involves: 129S1/Sv * 129X1/SvJ	MGI:4358579
cx2	Thra^tm1Jas/Thra^tm1Jas Thrb^tm1Olc/Thrb^tm1Olc	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:4358577
cx3	Thra^tm1Jas/Thra^+ Thrb^tm1Olc/Thrb^tm1Olc	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:4358578

Genotype
MGI:4358579

hm1

• Allelic Composition: Thra^tm1Jas/Thra^tm1Jas
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:52829 )

• small and disorganized

thyroid gland hypoplasia ( J:52829 )

digestive/alimentary system

abnormal enterocyte morphology ( J:84537 )

• enterocyte differentiation is impaired

abnormal intestinal mucosa morphology ( J:84537 )

• decrease in thickness of the mucosa

abnormal intestinal goblet cell morphology ( J:84537 )

• decrease in the number of goblet cells in the ileum

abnormal small intestine morphology ( J:52829 )

• at 2 weeks, the intestine is more fragile than in wild-type mice

• intestinal size and length of crypt-villus units are reduced compared to in wild-type mice

decreased small intestinal villus height ( J:84537 )

• reduction in villus height that results from a decrease in the number of epithelial cells per crypt-villus axis

decreased small intestine length ( J:52829 )

• at 2 weeks, the intestine is shorter than in wild-type mice

abnormal enterocyte physiology ( J:84537 )

• enterocytes show a large decrease in lactase and sucrase enzyme activity

abnormal enterocyte proliferation ( J:84537 )

• number of proliferating epithelial cells per crypt is reduced in the distal small intestine

cardiovascular system

decreased heart ventricle muscle contractility ( J:68577 )

• time to peak tension and time to 50% relaxation are prolonged compared to in wild-type mice

decreased heart rate ( J:68577 )

prolonged QRS complex duration ( J:68577 )

• QRS duration is increased compared to in wild-type mice

skeleton

abnormal long bone epiphyseal plate morphology ( J:52829 )

• prior to hypothyroidy, mice exhibit impaired development of epiphyseal bone centers characterized by hypertrophied cartilage associated with low ossification unlike in wild-type mice

homeostasis/metabolism

decreased circulating thyroxine level ( J:68577 )

abnormal enzyme/coenzyme activity ( J:84537 )

• enterocytes show a large decrease in lactase and sucrase enzyme activity

muscle

decreased heart ventricle muscle contractility ( J:68577 )

• time to peak tension and time to 50% relaxation are prolonged compared to in wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:84537 )

• decrease in the number of goblet cells in the ileum

abnormal enterocyte proliferation ( J:84537 )

• number of proliferating epithelial cells per crypt is reduced in the distal small intestine

Genotype
MGI:4358577

cx2

• Allelic Composition: Thra^tm1Jas/Thra^tm1Jas; Thrb^tm1Olc/Thrb^tm1Olc
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:52829 )

• at 5 weeks

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:52829 )

• increased in follicle number with different size, content, aspects of colloid, and development of vascularization

• follicles are smaller than normal and exhibit signs of hyperactivity including colloid vacuoles, cuboid epithelium, and hypervascularization

thyroid gland hyperplasia ( J:52829 )

• diffuse

homeostasis/metabolism

increased circulating thyroxine level ( J:52829 )

• 10-fold

increased triiodothyronine level ( J:52829 )

• 10-fold

increased circulating thyroid-stimulating hormone level ( J:52829 )

• 100-fold

skeleton

abnormal long bone epiphyseal plate morphology ( J:52829 )

• mice exhibit impaired development of epiphyseal bone centers characterized by hypertrophied cartilage associated with low ossification unlike in wild-type mice

delayed skeletal maturation ( J:52829 )

• bone maturation is delayed compared to in wild-type mice

digestive/alimentary system

delayed intestine development ( J:52829 )

• intestine maturation is delayed compared to in wild-type mice

abnormal small intestine morphology ( J:52829 )

• at 2 weeks, the intestine is shorter and more fragile than in wild-type mice

• as in Thra^tm1Jas homozygotes, proximal jejunum crypt-villus units length is reduced compared to in wild-type mice

• in the distal ileum epithelial cells are flat with few and short villi compared to in wild-type mice or Thra^tm1Jas homozygotes

decreased small intestinal villus size ( J:52829 )

• in the distal ileum and proximal jejunum

growth/size/body

decreased body weight ( J:52829 )

• after 3 weeks

postnatal growth retardation ( J:52829 )

• postnatal growth ceases at 15 days and after 3 weeks mice exhibit a decrease in body weight

Genotype
MGI:4358578

cx3

• Allelic Composition: Thra^tm1Jas/Thra⁺; Thrb^tm1Olc/Thrb^tm1Olc
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

growth/size/body

postnatal growth retardation ( J:52829 )