Phenotypes associated with this allele

• Allele Symbol: Rela^tm1Yuo
• Allele Name: targeted mutation 1, Yuichi Obata
• Allele ID: MGI:1860444
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rela^tm1Yuo/Rela^tm1Yuo	involves: 129S/SvEv	MGI:3799260
cx2	Rela^tm1Yuo/Rela^tm1Yuo Tnf^tm1Ljo/Tnf^tm1Ljo	involves: 129S/SvEv * 129S1/Sv	MGI:3799266

Genotype
MGI:3799260

hm1

• Allelic Composition: Rela^tm1Yuo/Rela^tm1Yuo
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:63099 )

• mice die around E15.5

immune system

decreased double-positive T cell number ( J:63099 )

• in wild-type mice transplanted with fetal liver cells

abnormal lymphocyte physiology ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased B cell proliferation ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased T cell proliferation ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased IgA level ( J:63099 )

• 100-fold lower in wild-type mice transplanted with fetal liver cells

decreased IgG1 level ( J:63099 )

• 10-fold lower in wild-type mice transplanted with fetal liver cells

liver/biliary system

abnormal liver morphology ( J:63099 )

• at E14.5

abnormal hepatocyte morphology ( J:63099 )

• at E14.5, mice exhibit hepatocyte degeneration

hematopoietic system

decreased double-positive T cell number ( J:63099 )

• in wild-type mice transplanted with fetal liver cells

abnormal lymphocyte physiology ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased B cell proliferation ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased T cell proliferation ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased IgA level ( J:63099 )

• 100-fold lower in wild-type mice transplanted with fetal liver cells

decreased IgG1 level ( J:63099 )

• 10-fold lower in wild-type mice transplanted with fetal liver cells

muscle

abnormal myogenesis ( J:135692 )

• mouse embryonic fibroblasts exhibit increased myotube formation when stimulated with Myod1 expression compared to similarly treated wild-type mouse embryonic fibroblasts

• myogenesis is accelerated in myoblasts

cellular

decreased B cell proliferation ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

decreased T cell proliferation ( J:63099 )

• lymphocyte proliferation is decreased in wild-type mice transplanted with fetal liver following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies, LPS, anti-IgM antibodies, PMA and a calcium ionophore, and ConA

Genotype
MGI:3799266

cx2

• Allelic Composition: Rela^tm1Yuo/Rela^tm1Yuo; Tnf^tm1Ljo/Tnf^tm1Ljo
• Genetic Background: involves: 129S/SvEv * 129S1/Sv

muscle

abnormal myogenesis ( J:135692 )

• myogenesis is accelerated in myoblasts in cultured mouse embryonic fibroblasts and in vivo

decreased skeletal muscle fiber diameter ( J:135692 )

• mice exhibit a decrease in fiber diameter

increased skeletal muscle fiber number ( J:135692 )

• mutant mice exhibit a 76% increase in the number of myofibers