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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Thtm1Tna
targeted mutation 1, Toshiharu Nagatsu
MGI:1860453
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Thtm1Tna/Thtm1Tna either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR) MGI:2682637
ht2
Thtm1Tna/Th+ B6.129-Thtm1Tna MGI:3629513


Genotype
MGI:2682637
hm1
Allelic
Composition
Thtm1Tna/Thtm1Tna
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thtm1Tna mutation (0 available); any Th mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when offspring delivered by Cesarean section are cross-fostered by breeding females, viable homozygotes appear normal within 5-6 hrs after birth but die by P1 without any structural failure in major organs
• homozygotes are grossly normal up to E12.5; however, 55-57% of embryos die from E14.5 to E16.5 with a variable degree of degradation
• when delivered by Cesarean section at E18.5, 75% of homozygotes undergo resorption as a consequence of death
• 19% of homozygotes begin to breathe and turned pink within 10 min after birth; however, the remaining 6% die of anoxia within 10 min after birth

homeostasis/metabolism
• at E12.5, homozygotes show no detectable adrenaline levels
• newborn homozygotes delivered by Cesarean section display very low adrenaline levels in both head and body regions
• at E12.5, homozygotes display a dopamine level of 37.5% in the head and 7.7% in the body of wild-type levels
• newborn homozygotes delivered by Cesarean section display a dopamine level of only 23.0% in the head and 41.7% in the body of wild-type levels
• at E12.5, homozygotes show no detectable noradrenaline levels
• newborn homozygotes delivered by Cesarean section display very low noradrenaline levels in both head and body regions
• when delivered by Cesarean section at E18.5, 6% of homozygotes die of anoxia within 10 min after birth

respiratory system
• homozygotes dying at birth exhibit atelectasis with no structural blockage in bronchi, bronchioles, and upper respiratory tract; however, signs of degeneration are noted in heart, liver and kidney
• when delivered by Cesarean section at E18.5, 6% of homozygotes fail to breathe and respond poorly to a tapping stimulus

cardiovascular system
• newborn homozygotes delivered by Cesarean section show significant bradycardia relative to wild-type mice (210 17 bpm vs 307 9 bpm, respectively)
• newborn homozygotes delivered by Cesarean section show a slight elevation of the S-T segment; however, no major differences in wave morphology are observed on surface electrocardiograms




Genotype
MGI:3629513
ht2
Allelic
Composition
Thtm1Tna/Th+
Genetic
Background
B6.129-Thtm1Tna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thtm1Tna mutation (0 available); any Th mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• heterozygotes exhibit impairment in the water-finding task associated with latent learning performance; training fails to shorten the finding and drinking latencies, despite normal locomotor activity and exploratory behavior
• post-training latencies for both finding and drinking performances are restored by desipramine-induced stimulation of noradrenergic activity
• heterozygotes exhibit mild impairment in long-term memory formation in three distinct forms of associative learning (active avoidance, cued fear conditioning, and conditioned taste aversion)
• associative learning deficits are restored by desipramine-induced stimulation of noradrenergic activity
• notablty, spatial learning and hippocampal long-term potentiation remain unaffected

homeostasis/metabolism
• heterozygotes show a moderate reduction of noradrenaline levels in brains regions, including the frontal cortex, midbrain, hypothalamus, hippocampus and pons medulla, to 73%-80% of wild-type levels
• measurement of extracellular noradrenaline levels in the frontal cortex by microdialysis indicates a significant reduction in high K+-evoked noradrenaline release





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory