All Phenotypes Mip<Cts> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mip^Cts
cataract and small eye
MGI:1860482

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mip^Cts/Mip^Cts	CTA/Idr	MGI:3818560
hm2	Mip^Cts/Mip^Cts	CTS/Shi	MGI:5487835
hm3	Mip^Cts/Mip^Cts	involves: Jcl:ICR	MGI:3818558
ht4	Mip^Cts/Mip⁺	(CTA/Idr x C57BL/6J)F1	MGI:3818565
ht5	Mip^Cts/Mip⁺	(CTA/Idr x ICR/Jcl)F1	MGI:3818566
ht6	Mip^Cts/Mip⁺	(CTA/Idr x KYF/MsIdr)F1	MGI:3818564
ht7	Mip^Cts/Mip⁺	(CTA/Idr x MT/HokIdr)F1	MGI:3818567
ht8	Mip^Cts/Mip⁺	(CTS/Shi x C57BL/6J)F1	MGI:5487832
ht9	Mip^Cts/Mip⁺	(CTS x KYF/MsIdr)F1	MGI:3818562
ht10	Mip^Cts/Mip⁺	involves: C57BL/6J * CTS/Shi	MGI:5487914
ht11	Mip^Cts/Mip⁺	involves: Jcl:ICR	MGI:3818557

Allelic Composition	Mip^Cts/Mip^Cts
Genetic Background	CTA/Idr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens fiber morphology ( J:14881 )

• dispositions of lens fibers and unequal size of fiber nuclei are noticed at E15

• the anterior pole of the lens can have masses of degenerated lens fibers interspersed with vacuoles during fetal development

hydropic eye lens fibers ( J:14881 )

• initial changes in lens structure occur at E15 when lens fibers around the lenticular nucleus swell and transform into spindle shapes

developmental cataract ( J:14881 )

• mice have cataracts when eyes are first opened

• initial changes in lens structure occur at E15 when lens fibers around the lenticular nucleus swell and transform into spindle shapes

• dispositions of lens fibers and unequal size of fiber nuclei are also noticed at this stage

• the anterior pole of the lens can have masses of degenerated lens fibers interspersed with vacuoles

• these morphological lens changes progress gradually into cataracts

microphthalmia ( J:14881 )

• microphthalmia is noted when eyes are first opened with eyes being about half the size of controls

Allelic Composition	Mip^Cts/Mip^Cts
Genetic Background	CTS/Shi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens development ( J:196356 )

• all mice of this inbred strain were found to have abnormal lense structure with the lenses spaced with vacuoles

lens vacuoles ( J:196356 )

cataract ( J:196356 )

• in all mice of this inbred background

microphthalmia ( J:196356 )

• in all mice of this inbred background, but heterozygotes from an outcross to C57BL/6J do not have microphthalmia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:196356

Allelic Composition	Mip^Cts/Mip^Cts
Genetic Background	involves: Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:24627 )

• all mice are affected

• either one or both eyes show opacity of the lens

• a milky-white spot is easily visible in the lens of affected eyes

microphthalmia ( J:24627 )

• mice have small eyes with the lens about half the size of controls

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 73.9% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 26.1% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x ICR/Jcl)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 19.9% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 80.1% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x KYF/MsIdr)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• all mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x MT/HokIdr)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 7.1% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 92.9% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTS/Shi x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens development ( J:196356 )

cataract ( J:196356 )

• 100% of heterozygous F1 mice develop cataracts, but these are less well-developed than those of homozygous CTS/Shi mice and they do not display microphthalmia

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTS x KYF/MsIdr)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 91.5% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 8.5% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	involves: C57BL/6J * CTS/Shi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens development ( J:196356 )

cataract ( J:196356 )

• heterozgyotes in the N2 to C57BL/6J population have bilateral cataracts less severe than in CTS/Shi homozygotes, and lack the microphthalmia of homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:196356

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	involves: Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:24627 )

• all mice are affected

• either one or both eyes show opacity of a normal-sized lens

• a milky-white spot is easily visible in the lens of affected eyes

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