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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H19tm1Lda
targeted mutation 1, Luisa Dandolo
MGI:1860792
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H19tm1Lda/H19tm1Lda involves: 129S2/SvPas MGI:3845807
hm2
 		H19tm1Lda/H19tm1Lda involves: 129S2/SvPas * C57BL/6 * CBA MGI:3845816
ht3
 		H19tm1Lda/H19+ involves: 129S2/SvPas MGI:3845808
cx4
 		Apctm1Cip/Apc+
H19tm1Lda/H19+ 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:3845818
cx5
 		Apctm1Cip/Apc+
H19tm1Lda/H19+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:3845817


Genotype
MGI:3845807
hm1
Allelic
Composition		 H19tm1Lda/H19tm1Lda
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Lda mutation (1 available); any H19 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:41236 )
• mice are 8% heavier than normal




Genotype
MGI:3845816
hm2
Allelic
Composition		 H19tm1Lda/H19tm1Lda
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Lda mutation (1 available); any H19 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor growth/size ( J:138826 )
• teratocarcinomas derived from E6.5 embryos grafted into wild-type mice grow 1.6-fold more than wild-type-derived tumors
• teratocarcinomas derived from E6.5 embryos grafted into Igf2tm1Rob homozygotes grow 2-fold more than wild-type-derived tumors




Genotype
MGI:3845808
ht3
Allelic
Composition		 H19tm1Lda/H19+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Lda mutation (1 available); any H19 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:41236 )
• mice are 8% heavier than normal when this allele is inherited maternally




Genotype
MGI:3845818
cx4
Allelic
Composition		 Apctm1Cip/Apc+
H19tm1Lda/H19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (158 available)
H19tm1Lda mutation (1 available); any H19 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased adenoma incidence ( J:138826 )
• mice exhibit a 1.4-fold increase in the number of adenomas compared to in Apctm1Cip heterozygotes




Genotype
MGI:3845817
cx5
Allelic
Composition		 Apctm1Cip/Apc+
H19tm1Lda/H19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (158 available)
H19tm1Lda mutation (1 available); any H19 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenocarcinoma incidence ( J:138826 )
• some adenocarcinoma in situ in the intestines
increased adenoma incidence ( J:138826 )
• mice exhibit a 2.2-fold increase in the number of adenomas compared to in Apctm1Cip heterozygotes

digestive/alimentary system
colon polyps ( J:138826 )
• mice exhibit a 3-fold increase in the number of small polyps compared to in Apctm1Cip heterozygotes
increased intestinal adenocarcinoma incidence ( J:138826 )
• some adenocarcinoma in situ in the intestines




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory