Phenotypes associated with this allele

• Allele Symbol: Hoxb^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:1860874
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb^tm1Brd/Hoxb^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2175069

Genotype
MGI:2175069

hm1

• Allelic Composition: Hoxb^tm1Brd/Hoxb^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:62577 )

• mice die by the first day after birth

skeleton

abnormal sternum morphology ( J:62577 )

• mice exhibit open sternums

decreased sternebra number ( J:62577 )

• the number of sternebrae is reduced compared to in wild-type mice

decreased sternebra size ( J:62577 )

• the size of sternebrae is reduced compared to in wild-type mice

split sternum ( J:62577 )

• the sternal bands are open unlike in wild-type mice

abnormal rib morphology ( J:62577 )

• rib 1 is reduced or absent and no longer connected to the sternum unlike in wild-type mice

• rib 8 is unusually long and sometimes joins the sternal bands on one side or both unlike in wild-type mice

rib fusion ( J:62577 )

• rib 1 often fuses to rib 2

thoracic vertebral transformation ( J:62577 )

• all mice exhibit a transformation of T8 to a T7 phenotype, T4 to a T3 or T2 phenotype, T2 to a T1 phenotype, and T1 to a C7 phenotype

small thoracic cage ( J:62577 )

• smaller than normal

abnormal spine curvature ( J:62577 )

• mice lack the ventral curvature of the vertebral column at the cervicothoracic boundary

abnormal cervical vertebrae morphology ( J:62577 )

• one or both anterior tuberculi on C6 is absent or fused with an abnormal ectopic tuberculi on C7 unlike in wild-type mice

• C7 exhibits vertebrarterial canals normally found on C1 to C6

abnormal cervical atlas morphology ( J:62577 )

• the neural arch on C1 is thinned compared to in wild-type mice

abnormal cervical axis morphology ( J:62577 )

• the neural arch on C2 is thickened and 12% of mice exhibit an extra central tubercle unlike in wild-type mice

cervical vertebral transformation ( J:62577 )

• C7 is transformed to a C6 phenotype in 92% of mice

• C6 is transformed to a C5 phenotype in 96% of mice

• all mice exhibit a transformation of C2 to C1 and 62% of mice exhibit an anterior transformation of C1

nervous system

abnormal glossopharyngeal nerve morphology ( J:62577 )

• at E10.5, 6 of 11 mice exhibit abnormal glossopharyngeal nerves including 3 of 11 with the glossopharyngeal nerve closer to the vagus nerve unilaterally, 1 of 11 with the glossopharyngeal nerve closer to the vagus nerve bilaterally, and 2 of 11 with the glossopharyngeal nerve absent unilaterally

absent glossopharyngeal nerve ( J:62577 )

• in 2 of 11 mice

abnormal vagus nerve morphology ( J:62577 )

• 1 of 11 mice exhibit abnormal migrating of the vagus nerve

fusion of glossopharyngeal and vagus nerve ( J:62577 )

• in some mice

cardiovascular system

abnormal heart position or orientation ( J:62577 )

• at E16.5

enlarged heart ( J:62577 )

• at E16.5

internal hemorrhage ( J:62577 )

• in some mice

growth/size/body

enlarged heart ( J:62577 )

• at E16.5

decreased birth body size ( J:62577 )

• body size reduced by 50% at birth

abnormal abdominal wall morphology ( J:62577 )

• the abdominal wall and sternal bands are open unlike in wild-type mice

homeostasis/metabolism

edema ( J:62577 )

• in some mice