Phenotypes associated with this allele

• Allele Symbol: Lta^tm1Jods
• Allele Name: targeted mutation 1, Jonathon D Sedgwick
• Allele ID: MGI:1860954
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta^tm1Jods/Lta^tm1Jods	C57BL/6-Lta^tm1Jods	MGI:2182152
hm2	Lta^tm1Jods/Lta^tm1Jods	involves: C57BL/6	MGI:3850560

Genotype
MGI:2182152

hm1

• Allelic Composition: Lta^tm1Jods/Lta^tm1Jods
• Genetic Background: C57BL/6-Lta^tm1Jods

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased lymphocyte cell number ( J:47428 )

• mice exhibit peripheral blood lymphocytosis

abnormal immune system organ morphology ( J:47428 )

abnormal spleen morphology ( J:47428 )

• spleen architecture is disrupted

abnormal spleen white pulp morphology ( J:78229 )

• spleen white pulp micro-architecture is severely disrupted

absent Peyer's patches ( J:47428 )

absent peripheral lymph nodes ( J:47428 )

hematopoietic system

increased lymphocyte cell number ( J:47428 )

• mice exhibit peripheral blood lymphocytosis

abnormal spleen morphology ( J:47428 )

• spleen architecture is disrupted

abnormal spleen white pulp morphology ( J:78229 )

• spleen white pulp micro-architecture is severely disrupted

Genotype
MGI:3850560

hm2

• Allelic Composition: Lta^tm1Jods/Lta^tm1Jods
• Genetic Background: involves: C57BL/6

immune system

abnormal thymus epithelium morphology ( J:125864 )

• medullary thymic epithelial cells that present self antigen are present in these mice

hematopoietic system

abnormal thymus epithelium morphology ( J:125864 )

• medullary thymic epithelial cells that present self antigen are present in these mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:125864 )

• medullary thymic epithelial cells that present self antigen are present in these mice