Phenotypes associated with this allele

• Allele Symbol: Ltb^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:1860955
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb^tm1Flv/Ltb^tm1Flv	involves: 129S1/Sv * C57BL/6J	MGI:3768265

Genotype
MGI:3768265

hm1

• Allelic Composition: Ltb^tm1Flv/Ltb^tm1Flv
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91927 )

• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls

immune system

abnormal spleen morphology ( J:39746 )

• spleen architecture is disrupted and the spleen is disorganized

abnormal spleen red pulp morphology ( J:39746 )

• mice exhibit leukocyte invasion of red pulp

abnormal spleen white pulp morphology ( J:39746 )

absent Peyer's patches ( J:39746 )

abnormal mesenteric lymph node morphology ( J:39746 )

• mesenteric lymph nodes are smaller than in wild-type

• B cell area is larger than in wild-type

absent peripheral lymph nodes ( J:39746 )

• peripheral lymph nodes are absent

• however, mesenteric and cervical lymph nodes are present

abnormal humoral immune response ( J:39746 )

• in response to stimulation with sheep red blood cells (SRBC), mice fail to produce anti-SRBC IgG at day 6 and only produce a negligible amount by day 15 unlike wild-type mice

• while mice produce wild-type levels of anti-NP following stimulation with NP-CGG, mice only show low levels of affinity maturation

decreased IgA level ( J:39746 )

hematopoietic system

abnormal spleen morphology ( J:39746 )

• spleen architecture is disrupted and the spleen is disorganized

abnormal spleen red pulp morphology ( J:39746 )

• mice exhibit leukocyte invasion of red pulp

abnormal spleen white pulp morphology ( J:39746 )

decreased IgA level ( J:39746 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91927 )

• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls