Phenotypes associated with this allele

• Allele Symbol: Lta^tm1Tab
• Allele Name: targeted mutation 1, Theresa A Banks
• Allele ID: MGI:1860957
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta^tm1Tab/Lta^tm1Tab	B6.129S2-Lta^tm1Tab	MGI:3718551
hm2	Lta^tm1Tab/Lta^tm1Tab	either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)	MGI:2182175
hm3	Lta^tm1Tab/Lta^tm1Tab	involves: 129S2/SvPas * C57BL/6	MGI:3652515

Genotype
MGI:3718551

hm1

• Allelic Composition: Lta^tm1Tab/Lta^tm1Tab
• Genetic Background: B6.129S2-Lta^tm1Tab

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to parasitic infection ( J:121070 )

• following infection with P. falciparum, mice are resistant to developing cerebral malaria but develop progressive parasitemia, severe anemia and pulmonary vascular leak

Genotype
MGI:2182175

hm2

• Allelic Composition: Lta^tm1Tab/Lta^tm1Tab
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

immune system

increased spleen weight ( J:28061 )

• spleen weights are between 195 ad 257 mg (0.8% to 1.1% of body weight) compared to wild-type spleens that weigh between 86 and 125 mg (0.35% to 0.6% of body weight)

increased leukocyte cell number ( J:28061 )

• some mice exhibit increased white blood cell (WBC) counts (11-29x10³ WBC per mm³ compared to 3-7x10³ WBC per mm³ in wild-type mice)

• small homogeneous lymphocytes accumulate in the periportal and perivascular regions of the liver and lung, respectively

absent spleen marginal zone ( J:28061 )

• unlike wild-type mice, the marginal zone is absent from the white pulp

decreased spleen white pulp amount ( J:28061 )

• the amount of white pulp is reduced, disorganized and lacked marginal zones

absent Peyer's patches ( J:28061 )

absent lymph nodes ( J:28061 )

• mice lack visible lymph nodes (popliteal, inguineal, para-aortic, axillary and cervical)

• however, 4 of 14 mice possess abnormal lymph node-like structures in the mesenteric fat

abnormal humoral immune response ( J:28061 )

• when exposed to HSV or KLH mice fail to produce antigen-specific antibodies

decreased IgA level ( J:28061 )

• less than 20 ug/ul compared to 80-1668 ug/ml in wild-type mice

increased IgM level ( J:28061 )

• 20+/-6 mg/dl compared to 15+/-3 mg/dl in wild-type mice

hematopoietic system

increased spleen weight ( J:28061 )

• spleen weights are between 195 ad 257 mg (0.8% to 1.1% of body weight) compared to wild-type spleens that weigh between 86 and 125 mg (0.35% to 0.6% of body weight)

increased leukocyte cell number ( J:28061 )

• some mice exhibit increased white blood cell (WBC) counts (11-29x10³ WBC per mm³ compared to 3-7x10³ WBC per mm³ in wild-type mice)

• small homogeneous lymphocytes accumulate in the periportal and perivascular regions of the liver and lung, respectively

absent spleen marginal zone ( J:28061 )

• unlike wild-type mice, the marginal zone is absent from the white pulp

decreased spleen white pulp amount ( J:28061 )

• the amount of white pulp is reduced, disorganized and lacked marginal zones

decreased IgA level ( J:28061 )

• less than 20 ug/ul compared to 80-1668 ug/ml in wild-type mice

increased IgM level ( J:28061 )

• 20+/-6 mg/dl compared to 15+/-3 mg/dl in wild-type mice

growth/size/body

increased spleen weight ( J:28061 )

• spleen weights are between 195 ad 257 mg (0.8% to 1.1% of body weight) compared to wild-type spleens that weigh between 86 and 125 mg (0.35% to 0.6% of body weight)

Genotype
MGI:3652515

hm3

• Allelic Composition: Lta^tm1Tab/Lta^tm1Tab
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

decreased tumor necrosis factor secretion ( J:109621 )

• in response to LPS, mice demonstrate a 10-fold decrease in production of TNF compared to wild-type or Lta^tm1.1Sned