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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf1atm1Blt
targeted mutation 1, Horst Bluethmann
MGI:1861040
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf1atm1Blt/Tnfrsf1atm1Blt B6.129P2-Tnfrsf1atm1Blt MGI:3622068
hm2
 		Tnfrsf1atm1Blt/Tnfrsf1atm1Blt C.129P2-Tnfrsf1atm1Blt MGI:3622067
hm3
 		Tnfrsf1atm1Blt/Tnfrsf1atm1Blt involves: 129P2/OlaHsd MGI:5573127
hm4
 		Tnfrsf1atm1Blt/Tnfrsf1atm1Blt involves: 129P2/OlaHsd * C57BL/6 MGI:3622070
hm5
 		Tnfrsf1atm1Blt/Tnfrsf1atm1Blt involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:4354644
ht6
 		Tnfrsf1atm1Blt/Tnfrsf1a+ involves: 129P2/OlaHsd MGI:5573128
cn7
 		Tnfrsf1atm1Blt/Tnfrsf1atm2Gkl
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * 129S/SvEv MGI:3687172
cx8
 		Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm 		involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4843969
cx9
 		Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4838237
cx10
 		Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3622063
cx11
 		Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4461138


Genotype
MGI:3622068
hm1
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background		 B6.129P2-Tnfrsf1atm1Blt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired central nervous system regeneration ( J:71178 )
• 7 days after traumatic spinal cord injury increased cell death is seen in the spinal cord compared to wild-type or Tnfrsf1btm1Mwm homozygotes
• 7 days after traumatic spinal cord injury the rostrocaudal spread of the lesion is increased and tissue destruction is more severe compared to wild-type mice
• 4 weeks after traumatic spinal cord injury locomotor performance is significantly more impaired and lesions are longer

behavior/neurological
abnormal sleep pattern ( J:103266 )
• after sleep deprivation, mice exhibit increased slow 'slow waves' and negative rebound during the dark period unlike wild-type mice




Genotype
MGI:3622067
hm2
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background		 C.129P2-Tnfrsf1atm1Blt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:87476 )
• decreased mortality is seen after exposure to 750 mg acetaminophen /kg

homeostasis/metabolism
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:87476 )
• decreased mortality is seen after exposure to 750 mg acetaminophen /kg
decreased physiological sensitivity to xenobiotic ( J:87476 )
• little or no liver damage, reduced infiltration of neutrophils and macrophages into the liver, and reduced intrahepatic chemokine production are seen after exposure to 600 mg acetaminophen /kg




Genotype
MGI:5573127
hm3
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Germinal centers and follicular dendritic cell networks are absent in Tnfrsf1atm1Blt/Tnfrsf1atm1Blt mice immunized with sheep red blood cells

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:210950 )
• all mice infected with Listeria monocytogenes die unlike wild-type mice
decreased susceptibility to induced morbidity/mortality ( J:210950 )
• no mice treated with TNF die unlike wild-type mice

immune system
impaired humoral immune response ( J:210950 )
• mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice
increased susceptibility to bacterial infection induced morbidity/mortality ( J:210950 )
• all mice infected with Listeria monocytogenes die unlike wild-type mice

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:210950 )
• TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice

cellular
increased sensitivity to induced cell death ( J:210950 )
• in mouse embryonic fibroblasts exposed to hypoxia




Genotype
MGI:3622070
hm4
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent follicular dendritic cells ( J:40970 )
• organized follicular dendritic cell networks are absent
abnormal Peyer's patch morphology ( J:40970 )
• the typical subepithelial dome areas fail to form
abnormal Peyer's patch follicle morphology ( J:40970 )
• B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent
decreased Peyer's patch number ( J:40970 )
• average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice
• however, T cell populations in the thymus and T and B cell populations in the spleen and lymph nodes are normal
abnormal lymph node B cell domain morphology ( J:40970 )
• B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however B cells are present and B and T cell areas are segregated
decreased IgG1 level ( J:115225 )
• following treatment with MOG
increased susceptibility to type I hypersensitivity reaction ( J:92307 )
• significant reduction in bronchoalveolar lavage leukocytosis in an ovalbumin-induced allergic asthma model
decreased interleukin-6 secretion ( J:14424 )
• LPS-induced IL-6 secretion is reduced about 3-fold compared to wild-type mice; however TNF secretion is similar to wild-type
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )
• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice
increased susceptibility to bacterial infection ( J:14424 )
• infection with as few as 250 colony forming units of Listeria monocytogenes results in 100% mortality by 6 days after infection, all wild-type mice survive this treatment
• D-galactosamine sensitized homozygotes can survive 100-fold higher concentrations of LPS than wild-type; however without D-galactosamine sensitization both types of mice show similar sensitivity to LPS-induced mortality
• however, homozygotes are able to control infections of lymphocytic choriomeningitis virus
increased susceptibility to parasitic infection ( J:114203 )
• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice
• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

hematopoietic system
decreased IgG1 level ( J:115225 )
• following treatment with MOG




Genotype
MGI:4354644
hm5
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating alanine transaminase level ( J:50903 )
• following exposure to Pseudomonas aerugiosa exotoxin

immune system
decreased susceptibility to bacterial infection ( J:50903 )
• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice




Genotype
MGI:5573128
ht6
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1a+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:210950 )
• no mice treated with TNF die unlike all wild-type mice

immune system
decreased circulating interleukin-6 level ( J:210950 )
• decreased induction in TNF-treated mice

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:210950 )
• decreased induction in TNF-treated mice
abnormal response/metabolism to endogenous compounds ( J:210950 )
• TNF-treated mice fail to exhibit lethality, as great IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice




Genotype
MGI:3687172
cn7
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm2Gkl
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cr2-cre)3Cgn mutation (2 available)
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113314 )
N
• architecture of all secondary lymphoid organs is similar to wild-type




Genotype
MGI:4843969
cx8
Allelic
Composition		 Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased leukocyte cell number ( J:119206 )
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
increased eosinophil cell number ( J:119206 )
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
increased lymphocyte cell number ( J:119206 )
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
absent spleen germinal center ( J:119206 )
• despite the absence of germinal centers the white pulp has distinct T and B cell areas
small Peyer's patches ( J:119206 )
• grossly unidentifiable and histologically hypoplastic
abnormal lymph node cortex morphology ( J:119206 )
• thin and lack primary and secondary cortical follicles
lung inflammation ( J:119206 )
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii
increased susceptibility to fungal infection ( J:119206 )
• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection
• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice

hematopoietic system
increased leukocyte cell number ( J:119206 )
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
increased eosinophil cell number ( J:119206 )
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
increased lymphocyte cell number ( J:119206 )
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
absent spleen germinal center ( J:119206 )
• despite the absence of germinal centers the white pulp has distinct T and B cell areas

respiratory system
lung inflammation ( J:119206 )
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii




Genotype
MGI:4838237
cx9
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:119206 )
N
• mice are able to clear infections of Pneumocystis carinii similar to controls
absent spleen germinal center ( J:119206 )
• despite the absence of germinal centers the white pulp has distinct T and B cell areas
decreased IgG1 level ( J:115225 )
• following treatment with MOG
small Peyer's patches ( J:119206 )
• grossly unidentifiable and histologically hypoplastic
abnormal lymph node cortex morphology ( J:119206 )
• thin and lack primary and secondary cortical follicles
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )
• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice
increased susceptibility to parasitic infection ( J:114203 )
• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice
• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

hematopoietic system
absent spleen germinal center ( J:119206 )
• despite the absence of germinal centers the white pulp has distinct T and B cell areas
decreased IgG1 level ( J:115225 )
• following treatment with MOG




Genotype
MGI:3622063
cx10
Allelic
Composition		 Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased circulating tumor necrosis factor level ( J:54056 )
• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice
• however, no signs of arthritis or inflammatory bowel disease are detected
increased tumor necrosis factor secretion ( J:54056 )
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls

homeostasis/metabolism
increased circulating tumor necrosis factor level ( J:54056 )
• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice
• however, no signs of arthritis or inflammatory bowel disease are detected




Genotype
MGI:4461138
cx11
Allelic
Composition		 Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation (1 available)
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:106592 )
• neurological symptoms by the sixth month of age, delayed compared to Tg alone
demyelination ( J:106592 )
• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
 J:106592




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Send questions and comments to User Support. 		last database update
11/12/2024
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