All Phenotypes Hm MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hm
hammertoe
MGI:1861096

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hm/Hm	C3Fe.Cg-Hm	MGI:3711055
ht2	Hm/Hm⁺	C3Fe.Cg-Hm	MGI:3711053
cx3	Hm/Hm⁺ Rr29^Hx/Rr29⁺	C3Fe.Cg-Hm +/+ Rr29^Hx	MGI:3711061
cx4	Hm/Del(5D5Mit73-D5Mit351)5Jcs	involves: 129S4/SvJae * C57BL/6J	MGI:3027472

Allelic Composition	Hm/Hm
Genetic Background	C3Fe.Cg-Hm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hm mutation (3 available); any Hm mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

abnormal phalanx morphology ( J:13425 , J:43743 )

• detectable by E14.5 (J:43743)

interdigital webbing ( J:43743 , J:68687 )

• webbing between digits 2,3,4, and 5 extends to the nails in the hindfeet; to the base of the distal phalanx in the forefeet (J:43743)

• webbing is extensive and prevents toe elongation, resulting in severe flexion at birth (J:43743)

• complete webbing with normal tibia (J:68687)

skeleton

abnormal phalanx morphology ( J:13425 , J:43743 )

• detectable by E14.5 (J:43743)

Allelic Composition	Hm/Hm⁺
Genetic Background	C3Fe.Cg-Hm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hm mutation (3 available); any Hm mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

abnormal phalanx morphology ( J:13425 , J:43743 )

• on all four feet, the second phalanx of digits 2,3,4,and 5 is strongly flexed (J:13425)

• detectable by E15 (J:43743)

interdigital webbing ( J:68687 )

• partial webbing

• webbing prevents toe elongation, resulting in flexion at birth

skeleton

abnormal phalanx morphology ( J:13425 , J:43743 )

• on all four feet, the second phalanx of digits 2,3,4,and 5 is strongly flexed (J:13425)

• detectable by E15 (J:43743)

Allelic Composition	Hm/Hm⁺ Rr29^Hx/Rr29⁺
Genetic Background	C3Fe.Cg-Hm +/+ Rr29^Hx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hm mutation (3 available); any Hm mutation (3 available)
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

polydactyly ( J:68687 )

• preaxial polydactyly with normal tibia

syndactyly ( J:68687 )

• syndactyly is more severe than seen in single heterozygous Hm mutants

interdigital webbing ( J:68687 )

• complete webbing of all hind feet digits that extend to the tip of the distal phalanges

Allelic Composition	Hm/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available); any Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available)
Hm mutation (3 available); any Hm mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

interdigital webbing ( J:63451 )

• retention of skin between digits giving the appearance of webbing

• this phenotype is identical to Hm heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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